A ship collision accident may pose a threat to human lives, the environment and material assets. A damaged ship can suffer from the loss of ship stability, reduced global structural strength, and the loss of the integrity of internal tanks carrying polluting liquids. This study presents a methodology as a framework that can be used to analyze the related consequences of ship-ship collision events using simulations and evaluations. The methodology includes nonlinear finite element analyses of the collision event, a METOCEAN data analysis module, damage stability simulations, analyses of the damaged ship’s ultimate strength and structural integrity, oil spill drift simulations, and finally, an evaluation of the three abovementioned consequences. A case study with a chemical tanker subjected to collision demonstrates the methodology. The collision event was assumed to occur in the Kattegat area (between Sweden and Denmark) at a ship route intersection with high ship traffic density. © 2022 The Author(s).