Imaging agent of a TRPA1 inhibitor
2013 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 56, no 9-10, p. 536-537Article in journal (Refereed) Published
Abstract [en]
A method for the preparation of [3'-3H]-4-(2'-chloro-6'- hydroxyphenyl)-2-thioxo-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5 (2H)-one (1), a TRPA1 inhibitor, was developed for the evaluation of imaging properties of a class of TRPA1 inhibitors. 1 was prepared via tritiation of a protected benzaldehyde followed by a tetrachlorosilane catalyzed multicomponent one-step fusion and was obtained at a specific activity of 0.9 TBq/mmol. A 3H-NMR spectrum on 13.5MBq at 75 μM was recorded.
Place, publisher, year, edition, pages
2013. Vol. 56, no 9-10, p. 536-537
Keywords [en]
3H, Isotopically labeled synthesis, NMR, TRPA1
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-6554DOI: 10.1002/jlcr.3030Scopus ID: 2-s2.0-84894342540Local ID: 23838OAI: oai:DiVA.org:ri-6554DiVA, id: diva2:964392
2016-09-082016-09-082023-05-09Bibliographically approved