XRF spectrometry is extensively used for production factory control because of its high precision and rapidity of response. For very accurate boron determinations in glass, classical wet chemical methods are still the preferred method of choice as the x-ray irradiation of light elements produces only a weak fluorescent response. However, the new generation XRF instruments employing enhanced matrix correction models plus the greater availability of certified reference materials may significantly improve the analytical performance of XRF spectrometers for the determination of "difficult" elements like boron.