The fabrication and use of biocomposites are impressive innovations that can replace existing nonbiodegradable petroleum-based substances. Cellulose is an organic polymer with a wide range of compounds and applications. Nowadays, sustainable organic resource-based cellulosic biopolymers are significant components in the production of green adhesives. Additionally, biocomposites made from cellulose-based adhesives have outstanding biocompatibility, light weight, biodegradability, significant chemically modifying capacity, and eco-friendliness. Successful applications of cellulose-based adhesives include the field of medicine delivery, tissue engineering, and wound dressing. This adhesive has a broad range of applications in diverse field of biomedical engineering and wood industries. The nanoscale cellulose-based biocomposites of natural origin are setting the pace in this remarkable surge of innovation. In this chapter, cellulose is examined as a high-performance green adhesive for wood industries with no negative environmental effects and an emphasis on the numerous current applications and promising foreseeable future developments.