Magnetic hyperthermia with ϵ-Fe2O3nanoparticles 2020 (engelsk)Inngår i: RSC Advances, E-ISSN 2046-2069, Vol. 10, nr 48, s. 28786-28797Artikkel i tidsskrift (Fagfellevurdert) Published

Abstract [en]

Biocompatibility restrictions have limited the use of magnetic nanoparticles for magnetic hyperthermia therapy to iron oxides, namely magnetite (Fe3O4) and maghemite (γ-Fe2O3). However, there is yet another magnetic iron oxide phase that has not been considered so far, in spite of its unique magnetic properties: ϵ-Fe2O3. Indeed, whereas Fe3O4 and γ-Fe2O3 have a relatively low magnetic coercivity, ϵ-Fe2O3 exhibits a giant coercivity. In this report, the heating power of ϵ-Fe2O3 nanoparticles in comparison with γ-Fe2O3 nanoparticles of similar size (∼20 nm) was measured in a wide range of field frequencies and amplitudes, in uncoated and polymer-coated samples. It was found that ϵ-Fe2O3 nanoparticles primarily heat in the low-frequency regime (20-100 kHz) in media whose viscosity is similar to that of cell cytoplasm. In contrast, γ-Fe2O3 nanoparticles heat more effectively in the high frequency range (400-900 kHz). Cell culture experiments exhibited no toxicity in a wide range of nanoparticle concentrations and a high internalization rate. In conclusion, the performance of ϵ-Fe2O3 nanoparticles is slightly inferior to that of γ-Fe2O3 nanoparticles in human magnetic hyperthermia applications. However, these ϵ-Fe2O3 nanoparticles open the way for switchable magnetic heating owing to their distinct response to frequency. 

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Royal Society of Chemistry , 2020. Vol. 10, nr 48, s. 28786-28797

Emneord [en]

Biocompatibility, Cell culture, Coercive force, Hematite, Hyperthermia therapy, Magnetism, Magnetite, Magnetite nanoparticles, Cell cytoplasm, High frequency HF, Low-frequency, Magnetic coercivities, Magnetic heating, Magnetic hyperthermia, Magnetic iron oxides, Nanoparticle concentrations, Magnetic nanoparticles

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Identifikatorer

URN: urn:nbn:se:ri:diva-47680DOI: 10.1039/d0ra04361cScopus ID: 2-s2.0-85089694588OAI: oai:DiVA.org:ri-47680DiVA, id: diva2:1463242

Merknad

Funding details: P2020-PTDC-CTMNAN-4511-2014, E11/17R; Funding details: Ministerio de Ciencia, Innovación y Universidades, MCIU, PGC2018_095795_B_I00; Funding details: Horizon 2020, 801305, 829162; Funding details: UIDP/ 50011/2020, UIDB/50011/2020; Funding details: European Regional Development Fund, FEDER; Funding text 1: This work was supported by European Union's Horizon 2020 FET Open program [Grants no: 801305 and 829162] Spanish Ministry of Science Innovation and Universities [Grant no: PGC2018_095795_B_I00] and Diputación General de Aragón [E11/17R]. Authors would like to acknowledge the use of Servi-cio General de Apoyo a la Investigación-SAI, Universidad de Zaragoza. This work was developed within the scope of the projects CoolPoint P2020-PTDC-CTMNAN-4511-2014 and CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/ 50011/2020, nanced by national funds through the FCT/MEC and co-nanced by FEDER under the PT2020 Partnership Agreement.We acknowledge support of the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI). We thank Sara Maccagnano-Zacher, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a dra of this manuscript.

Tilgjengelig fra: 2020-09-01 Laget: 2020-09-01 Sist oppdatert: 2025-09-23bibliografisk kontrollert

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Ahrentorp, FredrikJohansson, Christer

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