Al2O3 was deposited by reactive high-power impulse magnetron sputtering at 600 C onto pre-deposited Ti2AlC(0001) thin films on Al2O3(0001) substrates. The Al2O 3 was deposited to a thickness of 65 nm and formed an adherent layer of epitaxial γ-Al2O3(111) as shown by transmission electron microscopy. The demonstration of epitaxial growth of γ-Al 2O3 on Ti2AlC(0001) open prospects for growth of crystalline alumina as protective coatings on Ti2AlC and related nanolaminated materials. The crystallographic orientation relationships are γ-Al2O3(111)//Ti2AlC(0001) (out-of-plane) and Al2O3//Ti2AlC(112̄0)γ-Al 2O3(22̄0)// Ti 2 AlC (112̄0) (in-plane) as determined by electron diffraction. Annealing in vacuum at 900 C resulted in partial decomposition of the Ti2AlC by depletion of Al and diffusion into and through the γ-Al2O3 layer.