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  • 51.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Borchardt, Per
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Organisk kemi (Kmo).
    Free-form-fabricated commercially pure Ti and Ti6Al4V porous scaffolds support the growth of human embryonic stem cell-derived mesodermal progenitors2012In: Scientific World Journal, E-ISSN 1537-744X, Vol. 2012, p. 646417-Article in journal (Refereed)
  • 52.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Hansson, M
    Grunditz, T
    Isaksson, Mats
    Jansson, Svante
    Mölne, Johan
    Berg, G
    Iodine Content and Distribution in Extratumoral and Tumor Thyroid Tissue Analyzed with X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry2008In: Thyroid., Vol. 18, no 11, p. 1215-1220Article in journal (Refereed)
  • 53.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Siljeström, Sandra
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Hode, Tomas
    Toporski, Jan
    Thiel, Volker
    Detection of organic biomarkers in crude oil using ToF-SIMS2009In: Organic Geochemistry, Vol. 40, p. 135-143Article in journal (Refereed)
  • 54.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Analysis of archaeal core ether lipids using time-of-flight secondary ion mass spectrometry (ToF-SIMS): Exploring a new concept for the study of biomarkers in geobiology2007In: Geobiology, Vol. 5, p. 75-83Article in journal (Refereed)
  • 55.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Ancient microbial activity recorded in fracture fillings from granitic rocks (Äspö Hard Rock Laboratory, Sweden)2012In: Geobiology, ISSN 1472-4677, E-ISSN 1472-4669, Vol. 10, no 4, p. 280-297Article in journal (Refereed)
  • 56.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Mass spectrometric imaging of lipids in brain tissue2004In: Anal. Chem., Vol. 76, p. 4271-4278Article in journal (Refereed)
  • 57.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    TOF-SIMS analysis of exhaled particles from patients with asthma and healthy controls2012In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 39, no 1, p. 59-66Article in journal (Refereed)
  • 58.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    TOF-SIMS imaging of lipids in cell membranes2005In: Surface and Interface Analysis, no Special Issue:Bio Surface and Interface Analysis, p. 1401-12Article in journal (Refereed)
    Abstract [en]

    Surface and Interface Analysis

  • 59.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Johansson, B
    Belazi, Dalila
    Stenvinkel, Peter
    Lindholm, Bengt
    Schalling, Martin
    TOF-SIMS analysis of adipose and muscle tissue from patients with chronic kidney disease2008In: Appl. Surface Sci, Vol. 255, p. 1177-1180Article in journal (Refereed)
  • 60.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Johansson, Björn
    Belazi, Dalila
    Stenvinkel, Peter
    Lindholm, Bengt
    Schalling, Martin
    TOF-SIMS analysis of adipose tissue from patients with chronic kidney disease.2008In: Applied Surface Science, Vol. 255, p. 1177-1180Article in journal (Refereed)
  • 61.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Stenlund, Patrik
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    A methodological study of the mechanics controlling implant fixation ex vivo2011In: Annual Conference of the European Society for Biomaterials; EBS 2011, 2011Conference paper (Other academic)
  • 62.
    Leefman, Tim
    et al.
    Georg-August-University of Göttingen, Germany; Macquarie University, Australia.
    Heim, Christine
    Georg-August-University of Göttingen, Germany.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Ionescu, Danny
    Max Planck Institute for Marine Microbiology, Germany; Leibniz Institute for Freshwater Ecology and Inland Fisheries, Germany.
    Reitner, Joachim
    Georg-August-University of Göttingen, Germany.
    Thiel, Volker
    Georg-August-University of Göttingen, Germany.
    An Imaging Mass Spectrometry Study on the Formation of Conditioning Films and Biofilms in the Subsurface (Äspö Hard Rock Laboratory, SE Sweden)2015In: Geomicrobiology Journal, ISSN 0149-0451, E-ISSN 1521-0529, Vol. 32, no 3-4, p. 197-206Article in journal (Refereed)
    Abstract [en]

    Conditioning films and biofilms forming on surfaces of solid materials exposed to aqueous media play a key role in in the interaction between the geo- and biospheres. In this study, time-of-flight secondary ion mass spectrometry and scanning electron microscopy were used to investigate the time scale, mode of formation, and chemistry of conditioning films and biofilms that formed on Si substrates exposed to aquifer water in the subsurface Äspö Hard Rock Laboratory, SE-Sweden. The detection of fragment ions of amino acids, carbohydrates, and carboxylic acids revealed that different types of organic compounds had adhered to the Si surface already after 10 min of exposure to the aquifer fluids, whereas the attachment of microbial cells was first observed after 1000 min. The organic compounds first formed isolated μm-sized accumulations and subsequently started to distribute on the wafer surface more homogenously. Simultaneously further microorganisms attached to the surface and formed biofilm-like cell accumulations after 3 months of exposure to aquifer water.

  • 63.
    Leefmann, Tim
    et al.
    University of Göttingen, Germany.
    Heim, Christine
    University of Göttingen, Germany.
    Siljeström, Sandra
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Blumenberg, Martin
    University of Göttingen, Germany.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Thiel, Volker
    University of Göttingen, Germany.
    Spectral characterization of ten cyclic lipids using time-of-flight secondary ion mass spectrometry2013In: Rapid Communications in Mass Spectrometry, ISSN 0951-4198, E-ISSN 1097-0231, Vol. 27, no 5, p. 565-581Article in journal (Refereed)
    Abstract [en]

    RATIONALE Over the last decade, the high lateral resolution and imaging capabilities of time-of-flight secondary ion mass spectrometry (ToF-SIMS) have increasingly stimulated interest in studying organic molecules in complex environmental materials. However, unlike with the established mass spectrometric techniques, the use of ToF-SIMS in the biogeosciences is still hampered by a lack of reference spectra of the relevant biomarker compounds. Here we present and interpret ToF-SIMS reference spectra of ten different cyclic lipids that are frequently used as biological tracers in ecological, organic geochemical and geobiological studies. METHODS Standard compounds of α,β,β-(20R, 24S)-24-methylcholestane, (22E)-ergosta-5,7,22-trien-3β-ol, 17α(H),21β-(H)-30-norhopane, hope-17(21)-ene, hop-22(29)-ene, 17β(H),21β(H)-bacteriohopane-32,33,34,35-tetrol, 17β(H), 21β(H)-35-aminobacteriohopane-32,33,34-triol, α-tocopherol, β,β-carotene, chlorophyll a, and cryosections of microbial mats and a fungus were analyzed using a ToF-SIMS instrument equipped with a Bi 3+ cluster ion source. RESULTS The spectra obtained from the standard compounds showed peaks in the molecular weight range (molecular ions, protonated and deprotonated molecules, adduct ions) and diagnostic fragment ion peaks in both, positive and negative ion modes. For the cyclic hydrocarbons, however, the positive ion mode spectra typically showed more and stronger characteristic peaks than the negative ion mode spectra. Using real world samples the capability of ToF-SIMS to detect and image selected compounds in complex organic matrices was tested. 17β(H),21β(H)-35- Aminobacteriohopane-32,33,34-triol, carotene and chlorophyll a were successfully identified in cryosections of microbial mats, and the distribution of ergosterol was mapped at μm resolution in a cryosection of a fungus (Tuber uncinatum). CONCLUSIONS This study further highlights the utility of ToF-SIMS for the identification and localization of lipids within environmental samples and as a technique for biomarker-related research in organic geochemistry and geobiology.

  • 64.
    Lehti, Satu
    et al.
    Wihuri Research Institute, Finland.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Käkelä, Reijo
    University of Helsinki, Finland.
    Mäyränpää, Mikko I.
    University of Helsinki, Finland.
    Kovanen, Petri T.
    Wihuri Research Institute, Finland.
    Öörni, Katariina
    Wihuri Research Institute, Finland.
    Spatial distributions of lipids in atherosclerosis of human coronary arteries studied by time-of-flight secondary ion mass spectrometry2015In: American Journal of Pathology, ISSN 0002-9440, E-ISSN 1525-2191, Vol. 185, no 5, p. 1216-1233Article in journal (Refereed)
    Abstract [en]

    The accurate spatial distribution of various lipid species during atherogenesis has remained unexplored. Herein, we used time-of-flight secondary ion mass spectrometry (TOF-SIMS) to analyze the lipid dis-tribution in human coronary artery cryosections. The images from the TOF-SIMS allowed visualization ofions derived from individual species of cholesterol esters, phospholipids, and triacylglycerols in thecontext of lesion characteristics and severity. In addition, cholesterol-containing crystal-like structureswere seen in high-resolution images of advanced lesions. The ratio of cholesterol fragment ions (m/z385:m/z 369) was found to differentiate unesterified cholesterol from cholesterol esters. This ratiochanged during atherogenesis and in different areas of the lesions, reflecting differences in theaccumulation of the two forms of cholesterol. Thus, atheromas were characterized by accumulation ofcholesterol esters with apolipoprotein B near the intima-media border, whereas in the complicatedlesions, unesterified cholesterol dominated in neovessel-containing areas enriched in glycophorin A.Interestingly, triacylglycerols were found in areas surrounding neovessels and lacking either form ofcholesterol. The lipid composition of the tunica media reflected the alterations observed in the intimallipids, yet being more subtle. The detailed molecular information obtained by TOF-SIMS revealedunanticipated differences in the type and composition of the accumulating lipids in different stages ofatherogenesis, notably the spatial segregation of cholesterol and triglycerides in the advancing lesions.

  • 65. Lindahl, Cecilia
    et al.
    Borchardt, Per
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Organisk kemi (Kmo).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Xia, Wei
    Enqvist, H
    Studies of early growth mechanisms of hydroxyapatite on single crystalline rutile – a model system for bioactive surfaces2010In: Journal of Materials Science: Materials in Medicine, Vol. 21, p. 2743-2749Article in journal (Refereed)
  • 66.
    Lindgren, Johan
    et al.
    Lund University, Sweden.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Carney, Ryan M.
    Brown University, USA.
    Uvdal, Per
    Lund University, Sweden.
    Gren, Johan A.
    Lund University, Sweden.
    Dyke, Gareth J. J.
    University of Southampton, United Kingdom.
    Schultz, Bo Pagh
    Muserum, Denmark.
    Shawkey, Matthew D.
    University of Akron, USA.
    Barnes, Kenneth R.
    Mosasaur Ranch Museum, USA.
    Polcyn, Michael J.
    Southern Methodist University, USA.
    Skin pigmentation provides evidence of convergent melanism in extinct marine reptiles2014In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 506, no 7489, p. 484-488Article in journal (Refereed)
    Abstract [en]

    Throughout the animal kingdom, adaptive colouration serves critical functions ranging from inconspicuous camouflage to ostentatious sexual display, and can provide important information about the environment and biology of a particular organism. The most ubiquitous and abundant pigment, melanin, also has a diverse range of non-visual roles, including thermoregulation in ectotherms. However, little is known about the functional evolution of this important biochrome through deep time, owing to our limited ability to unambiguously identify traces of it in the fossil record. Here we present direct chemical evidence of pigmentation in fossilized skin, from three distantly related marine reptiles: a leatherback turtle, a mosasaur and an ichthyosaur. We demonstrate that dark traces of soft tissue in these fossils are dominated by molecularly preserved eumelanin, in intimate association with fossilized melanosomes. In addition, we suggest that contrary to the countershading of many pelagic animals, at least some ichthyosaurs were uniformly dark-coloured in life. Our analyses expand current knowledge of pigmentation in fossil integument beyond that of feathers, allowing for the reconstruction of colour over much greater ranges of extinct taxa and anatomy. In turn, our results provide evidence of convergent melanism in three disparate lineages of secondarily aquatic tetrapods. Based on extant marine analogues, we propose that the benefits of thermoregulation and/or crypsis are likely to have contributed to this melanisation, with the former having implications for the ability of each group to exploit cold environments.

  • 67. Maria de Peppo, Giuseppe
    et al.
    Bigdeli, Narmin
    Lennerås, Maria
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Lindahl, Anders
    Karlsson, Camilla
    Hyllner, Johan
    Superior osteogenic capacity of human embryonic stem cells adapted to matrix-free growth compared to human mesenchymal stem cells2010In: Tissue Engineering A, Vol. 16, p. 3427-3440Article in journal (Refereed)
  • 68. Maria de Peppo, Giuseppe
    et al.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Lennerås, Maria
    Strehl, Raimund
    Hyllner, Johan
    Thomsen, Peter
    Karlsson, Camilla
    Osteogenic Potential of Human Mesenchymal Stem Cells and Human Embryonic Stem Cell-derived Mesodermal Progenitors: a Tissue Engineering Perspective2010In: Tissue Engineering A, Vol. 16, p. 3413-3426Article in journal (Refereed)
    Abstract [en]

    Tissue Engineering A, 16(11):3413-3426, 2010

  • 69.
    Möller, Kenneth
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Jansson, Anna
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Analysis of oxidative polymer degradation using 18O and TOF-SIMS spectrometry2002Conference paper (Other academic)
  • 70.
    Möller, Kenneth
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Jansson, Anna
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Degradation of post-consumer polypropylene materials exposed to simulated recycling – mechanical properties2003In: Polymer Degradation and Stability, Vol. 82, p. 37-46Article in journal (Refereed)
  • 71.
    Möller, Kenneth
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Boldizar, Antal
    Processing and thermo-oxidative aging of high impact polystyrene containing flame retardant2000In: American Chemical Society Division of Polymeric Materials: Science and Engineering..ACS 220th meeting in Washington, D.C., 20-24 August, 2000, 2000, , p. 101Conference paper (Other academic)
  • 72.
    Phan, Nhu T. N.
    et al.
    University of Gothenburg, Sweden; National Center Imaging Mass Spectrometry, Sweden.
    Fletcher, John S.
    University of Gothenburg, Sweden; National Center Imaging Mass Spectrometry, Sweden.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Ewing, Andrew G.
    University of Gothenburg, Sweden; National Center Imaging Mass Spectrometry, Sweden; Chalmers University of Technology, Sweden.
    TOf-SIMS imaging of lipids and lipid related compounds in Drosophila brain2014In: Surface and Interface Analysis, ISSN 0142-2421, E-ISSN 1096-9918, Vol. 46, no S1, p. 123-126Article in journal (Refereed)
    Abstract [en]

    Drosophila melanogaster (fruit fly) has a relatively simple nervous system but possesses high order brain functions similar to humans. Therefore, it has been used as a commonmodel system inbiological studies, particularly drug addiction. Here, the spatial distribution of biomolecules in the brain of the fly was studied using time-of-flight SIMS. Fly brains were analyzed frozen to prevent molecular redistribution prior to analysis. Different molecules were found to distribute differently in the tissue, particularly the eye pigments, diacylglycerides, and phospholipids, and this is expected to be driven by their biological functions in the brain. Correlations in the localization of these moleculeswere also observed using principal components analysis of image data, and this was used to identify peaks for further analysis. Furthermore, consecutive analyses following 10 keV Ar2500 + sputtering showed that different biomolecules respond differently to Ar2500 + sputtering. Significant changes in signal intensities between consecutive analyses were observed for high mass molecules including lipids.

  • 73. Prinz, Christelle
    et al.
    Malm, Jakob
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Höök, Fredrik
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Structural effects in the analysis of supported lipid bilayers by time-of-flight secondary ion mass spectrometry (TOF-SIMS)2007In: Langmuir, Vol. 23, p. 8035-8041Article in journal (Refereed)
  • 74.
    Schulz, Rita
    et al.
    ESA European Space Agency, The Netherlands.
    Hilchenbach, Martin
    Max Planck Institute for Solar System Research, Germany.
    Langevin, Yves
    CNRS, France; University of Paris-Sud, France.
    Kissel, Jochen
    Max Planck Institute for Solar System Research, Germany.
    Silén, Johan
    Finnish Meteorological Institute, Finland.
    Briois, Christelle
    CNRS, France; University of Orléans, France.
    Engrand, Cécile
    CNRS, France; University of Paris-Sud, France.
    Hornung, Klaus
    Universität der Bundeswehr, Germany.
    Baklouti, Donia
    CNRS, France; University of Paris-Sud, France.
    Bardyn, Anaïs
    CNRS, France; University of Orléans, France; LISA Laboratoire Interuniversitaire des Systèmes Atmosphériques, France.
    Cottin, Hervé
    LISA Laboratoire Interuniversitaire des Systèmes Atmosphériques, France.
    Fischer, Henning
    Max Planck Institute for Solar System Research, Germany.
    Fray, Nicolas
    LISA Laboratoire Interuniversitaire des Systèmes Atmosphériques, France.
    Godard, Marie
    CNRS, France; University of Paris-Sud, France.
    Lehto, Harry J.
    University of Turku, Finland.
    Le Roy, Léna
    University of Bern, Switzerland.
    Merouane, Sihane
    Max Planck Institute for Solar System Research, Germany.
    Orthous-Daunay, François Régis
    CNRS, France; Université Grenoble Alpes, France.
    Paquette, John A.
    Max Planck Institute for Solar System Research, Germany.
    Rynö, Jouni
    Finnish Meteorological Institute, Finland.
    Siljeström, Sandra
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Stenzel, Oliver
    Max Planck Institute for Solar System Research, Germany.
    Thirkell, Laurent
    CNRS, France; University of Orléans, France.
    Varmuza, Kurt
    Vienna University of Technology, Austria.
    Zaprudin, Boris
    University of Turku, Finland.
    Comet 67P/Churyumov-Gerasimenko sheds dust coat accumulated over the past four years2015In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 518, no 7538, p. 216-218Article in journal (Refereed)
    Abstract [en]

    Comets are composed of dust and frozen gases. The ices are mixed with the refractory material either as an icy conglomerate, or as an aggregate of pre-solar grains (grains that existed prior to the formation of the Solar System), mantled by an ice layer. The presence of water-ice grains in periodic comets is now well established. Modelling of infrared spectra obtained about ten kilometres from the nucleus of comet Hartley 2 suggests that larger dust particles are being physically decoupled from fine-grained water-ice particles that may be aggregates, which supports the icy-conglomerate model. It is known that comets build up crusts of dust that are subsequently shed as they approach perihelion. Micrometre-sized interplanetary dust particles collected in the Earth's stratosphere and certain micrometeorites are assumed to be of cometary origin. Here we report that grains collected from the Jupiter-family comet 67P/Churyumov-Gerasimenko come from a dusty crust that quenches the material outflow activity at the comet surface. The larger grains (exceeding 50 micrometres across) are fluffy (with porosity over 50 per cent), and many shattered when collected on the target plate, suggesting that they are agglomerates of entities in the size range of interplanetary dust particles. Their surfaces are generally rich in sodium, which explains the high sodium abundance in cometary meteoroids. The particles collected to date therefore probably represent parent material of interplanetary dust particles. This argues against comet dust being composed of a silicate core mantled by organic refractory material and then by a mixture of water-dominated ices. At its previous recurrence (orbital period 6.5 years), the comet's dust production doubled when it was between 2.7 and 2.5 astronomical units from the Sun, indicating that this was when the nucleus shed its mantle. Once the mantle is shed, unprocessed material starts to supply the developing coma, radically changing its dust component, which then also contains icy grains, as detected during encounters with other comets closer to the Sun.

  • 75.
    Siljeström, Sandra
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    A reduced organic carbon component in martian basalts2012In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 337, no 6091, p. 212-215Article in journal (Refereed)
  • 76.
    Siljeström, Sandra
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf). Carnegie Institution of Washington, USA.
    Freissinet, Caroline
    Carnegie Institution of Washington, USA; NASA Postdoctoral Program, USA.
    Goesmann, Fred
    Max-Planck-Institut für Sonnensystemforschung, Germany.
    Steininger, Harald
    Max-Planck-Institut für Sonnensystemforschung, Germany.
    Goez, Walter
    Max-Planck-Institut für Sonnensystemforschung, Germany.
    Steele, Andrew
    Carnegie Institution of Washington, USA.
    Amundsen, Hans Erik F.
    Earth and Planetary Exploration Services, Norway.
    Comparison of prototype and laboratory experiments on MOMA GCMS: Results from the AMASE11 campaign2014In: Astrobiology, ISSN 1531-1074, E-ISSN 1557-8070, Vol. 14, no 9, p. 780-797Article in journal (Refereed)
    Abstract [en]

    The characterization of any organic molecules on Mars is a top-priority objective for the ExoMars European Space Agency-Russian Federal Space Agency joint mission. The main instrument for organic analysis on the ExoMars rover is the Mars Organic Molecule Analyzer (MOMA). In preparation for the upcoming mission in 2018, different Mars analog samples are studied with MOMA and include samples collected during the Arctic Mars Analog Svalbard Expedition (AMASE) to Svalbard, Norway. In this paper, we present results obtained from two different Mars analog sites visited during AMASE11, Colletthøgda and Botniahalvøya. Measurements were performed on the samples during AMASE11 with a MOMA gas chromatograph (GC) prototype connected to a commercial mass spectrometer (MS) and later in home institutions with commercial pyrolysis-GCMS instruments. In addition, derivatization experiments were performed on the samples during AMASE11 and in the laboratory. Three different samples were studied from the Colletthøgda that included one evaporite and two carbonate-bearing samples. Only a single sample was studied from the Botniahalvøya site, a weathered basalt covered by a shiny surface consisting of manganese and iron oxides. Organic molecules were detected in all four samples and included aromatics, long-chained hydrocarbons, amino acids, nucleobases, sugars, and carboxylic acids. Both pyrolysis and derivatization indicated the presence of extinct biota by the detection of carboxylic acids in the samples from Colletthøgda, while the presence of amino acids, nucleobases, carboxylic acids, and sugars indicated an active biota in the sample from Botniahalvøya. The results obtained with the prototype flight model in the field coupled with repeat measurements with commercial instruments within the laboratory were reassuringly similar. This demonstrates the performance of the MOMA instrument and validates that the instrument will aid researchers in their efforts to answer fundamental questions regarding the speciation and possible source of organic content on Mars.

  • 77.
    Siljeström, Sandra
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Hode, Tomas
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Toporski, Jan
    Thiel, Volker
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Detection of biomarkers in oils using ToF-SIMS2007In: Geochimica et Cosmochimica Acta, Vol. 71, no 15, p. A937-Article in journal (Refereed)
  • 78.
    Siljeström, Sandra
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Hode, Tomas
    Thiel, Volker
    Heim, Christine
    ToF-SIMS possibilities in geobiology2008In: Astrobiology, Vol. 8, no 2, p. 329-Article in journal (Refereed)
  • 79.
    Siljeström, Sandra
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Thiel, Volker
    Hode, Tomas
    Heim, Christine
    Detection of organic biomarkers in crude oils using ToF-SIMS2008In: Organic Chemistry, Vol. 40, no 1, p. 135-143Article in journal (Refereed)
  • 80.
    Siljeström, Sandra
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Biomarker imaging of single diatom cells in a microbial mat using time-of-flight secondary ion mass spectrometry (ToF-SIMS)2013In: Organic Geochemistry, ISSN 0146-6380, E-ISSN 1873-5290, Vol. 57, no Apr, p. 23-33Article in journal (Refereed)
  • 81.
    Siljeström, Sandra
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Volk, Herbert
    CSIRO Earth Science and Resource Engineering, Australia; BP Exploration Operating Company Ltd, United Kingdom.
    George, Simon C.
    Macquarie University, Australia.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Dutkiewicz, Adriana
    University of Sydney, Australia.
    Hode, Tomas
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Analysis of single oil-bearing fluid inclusions in mid-Proterozoic sandstones (Roper Group, Australia)2013In: Geochimica et Cosmochimica Acta, ISSN 0016-7037, E-ISSN 1872-9533, Vol. 122, p. 448-463Article in journal (Refereed)
    Abstract [en]

    Hydrocarbons and organic biomarkers extracted from black shales and other carbonaceous sedimentary rocks are valuable sources of information on the biodiversity and environment of early Earth. However, many Precambrian hydrocarbons including biomarkers are suspected of being younger contamination. An alternative approach is to study biomarkers trapped in oil-bearing fluid inclusions by bulk crushing samples and subsequently analysing the extracted hydrocarbons with gas chromatography-mass spectrometry. However, this method does not constrain the hydrocarbons to one particular oil inclusion, which means that if several different generations of oil inclusions are present in the sample, a mix of the content from these oil inclusions will be analysed. In addition, samples with few and/or small inclusions are often below the detection limit. Recently, we showed that it is possible to detect organic biomarkers in single oil-bearing fluid inclusions using time-of-flight secondary ion mass spectrometry (ToF-SIMS). In the present study, single fluid inclusion analysis has been performed on Proterozoic samples for the first time. Four individual oil-bearing fluid inclusions, found in 1430. Ma sandstone from the Roper Superbasin in Northern Australia, were analysed with ToF-SIMS. The ToF-SIMS spectra of the oil in the different inclusions are very similar to each other and are consistent with the presence of n-alkanes/branched alkanes, monocyclic alkanes, bicyclic alkanes, aromatic hydrocarbons, and tetracyclic and pentacyclic hydrocarbons. These results are in agreement with those obtained from bulk crushing of inclusions trapped in the same samples. The capability to analyse the hydrocarbon and biomarker composition of single oil-bearing fluid inclusions is a major breakthrough, as it opens up a way of obtaining molecular compositional data on ancient oils without the ambiguity of the origin of these hydrocarbons. Additionally, this finding suggests that it will be possible to analyse minute oil samples beyond the capability of established techniques. This may allow the biomarker record of the biosphere, as preserved in fluid inclusions, to be extended further back in time, and hence makes it possible to more accurately trace the early evolution of life on Earth, and search for life on other planets or moons.

  • 82.
    Sjögren, Torsten
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Hållfasthet (BMh).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Snis, Anders
    Engqvist, Håkan
    Karlsson, Joakim
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Digital image correlation analysis of local strain fields on Ti6A14V manufactured by electron beam melting2014In: Materials Science & Engineering A, Vol. 618, p. 456-461Article in journal (Other academic)
  • 83.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Chemical and structural analysis of the bone-implant interface by TOF-SIMS, SEM, FIB and TEM: Experimental study in animal2012In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 258, no 17, p. 6485-6494Article in journal (Refereed)
  • 84.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Chemical characterization of combustion deposits by TOF-SIMS2003In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 203, no 203, p. 669-672Article in journal (Other academic)
  • 85.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Kemisk/fysikalisk karaktärisering av avlagringar2001Report (Refereed)
  • 86.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging2013In: Acta Neuropathologica, ISSN 0001-6322, E-ISSN 1432-0533, Vol. 125, no 1, p. 145-157Article in journal (Refereed)
  • 87.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: Possible role of endocannabinoids2011In: PLOS ONE, E-ISSN 1932-6203, Vol. 7, no 6, p. e38834-Article in journal (Refereed)
  • 88.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Post-glacial microbialite formation in coral reefs of the Pacific, Atlantic, and Indian Oceans2012In: Chemical Geology, ISSN 0009-2541, E-ISSN 1872-6836, Vol. 304, no Apr, p. 117-130Article in journal (Refereed)
  • 89.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Relative quantification of phospholipid accumulation in the PC12 cell plasma membrane following phospholipid incubation using TOF-SIMS imaging2011In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 83, no 13, p. 5337-5343Article in journal (Refereed)
  • 90.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Surface analysis of precision weights for the study of commonly occurring contaminants2005In: Nanoscale calibration standards and methods, 2005, p. 434-442Chapter in book (Other (popular science, discussion, etc.))
  • 91.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    TOF-SIMS imaging of spatial distribution of lipids in cells2002Conference paper (Other academic)
  • 92.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Using time-of-flight secondary ion mass spectrometry to study biomarkers2011In: Annual Review of Earth and Planetary Science, ISSN 0084-6597, E-ISSN 1545-4495, Vol. 39, p. 125-156Article in journal (Refereed)
  • 93.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf). Chalmers University of Technology, Sweden.
    Agnarsson, Björn
    Chalmers University of Technology, Sweden.
    Carlred, Louise
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. Chalmers University of Technology, Sweden.
    Gunnarsson, Anders
    Chalmers University of Technology, Sweden.
    Höök, Fredrik F.
    Chalmers University of Technology, Sweden.
    Liposome binding for multiplexed biomolecule detection and imaging using ToF-SIMS2014In: Surface and Interface Analysis, ISSN 0142-2421, E-ISSN 1096-9918, Vol. 46, no 10-11, p. 707-711Article in journal (Refereed)
    Abstract [en]

    A novel approach for multiplexed biomolecule detection at surfaces, involving specific binding of liposomes and subsequent analysis by time-of-flight secondary ion mass spectrometry (ToF-SIMS), was evaluated with respect to its capability for quantitative analysis of biomolecule surface concentrations. The specific binding of liposomes to a poly(L-lysine)-g-poly (ethylene glycol) (PLL-g-PEG) surface, using the biotin-avidin coupling chemistry, was characterized by quartz crystal microbalance with dissipation monitoring (QCM-D), fluorescence microscopy and ToF-SIMS. The ToF-SIMS results showed a linearly increasing signal from the liposomes up to a saturation coverage corresponding to a full liposome layer on the surface, in close agreement with fluorescence microscopy analysis of the same samples, strongly supporting the potential of the liposome-based approach for quantitative biomolecule detection. However, the multiplexing capability and issues on nonspecific binding need further studies. Furthermore, an improved method for the preparation of lipid bilayer samples for ToF-SIMS analysis is presented, demonstrating the imaging of individual 210-nm diameter liposomes adsorbed on a SiO2 surface.

  • 94.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Almstrand, Ann-Charlotte
    Ljungström, Evert
    Bake, Björn
    Bredberg, Anna
    Olin, Anna-Carin
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Airway monitoring by collection and mass spectrometric analysis of exhaled particles2009In: Analytical Chemistry, Vol. 81, no 2, p. 662-8Article in journal (Refereed)
  • 95.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Belazi, D
    Solé Domenèch, Santiago
    Johansson, Björn
    Schalling, Martin
    Chemical analysis of osmium tetroxide staining in adipose tissue using imaging ToF-SIMS2009In: Histochemistry and Cell Biology, Vol. 132, no 1, p. 105-15Article in journal (Other academic)
  • 96.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Greve, Tanja Maria
    LEO Pharma A/S, Denmark.
    Clausen, Susanne K.
    LEO Pharma A/S, Denmark.
    Möller, Kristian
    LEO Pharma A/S, Denmark.
    Eirefelt, Stefan J.
    LEO Pharma A/S, Denmark.
    Johansson, Björn
    Karolinska Institute, Sweden.
    Nielsen, Kim Troensegaard
    LEO Pharma A/S, Denmark.
    Imaging of distribution of topically applied drug molecules in mouse skin by combination of time-of-flight secondary ion mass spectrometry and scanning electron microscopy2014In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 86, no 7, p. 3443-3452Article in journal (Refereed)
    Abstract [en]

    In the development of topical drugs intended for local effects in the skin, one of the major challenges is to achieve drug penetration through the external barrier of the skin, stratum corneum, and secure exposure to the viable skin layers. Mass spectrometric imaging offers an opportunity to study drug penetration in a variety of skin models by mapping the spatial distribution indifferent skin layers after topical application of the drug. In this study, we used time-of-flight secondary ion mass spectrometry (TOF-SIMS) and scanning electron microscopy (SEM) to image the distribution of three drug molecules in skin tissue cross sections of inflamed mouse ear. The three compounds, roflumilast, tofacitinib, and ruxolitinib, were topically administered to the mouse ears, which were subsequently cryosectioned and thawed for the analyses. The results reveal that the combination of TOF-SIMS and SEM was beneficial for interpretation of drug distribution. SEM identified the different skin layers, while spatial distributions of all three compounds could be visualized by TOF-SIMS, showing that the drug was primarily distributed into, or on the top of, the stratum corneum. Imaging of endogenous skin components like cholesterol, phospholipids, ceramides, and free fatty acids showed distributions in good agreement with the literature. One limitation of the TOF-SIMS method is sensitivity, typically allowing for analysis in the millimolar range rather than the pharmacologically relevant micromolar range. However, the data presented demonstrate the potential of the technique for studying the penetration of drugs with different physicochemical properties in skin.

  • 97.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Lanekoff, Ingela
    Kurczy, Michael E.
    Adams, Kelly L.
    Malm, Jakob
    Karlsson, Roger
    Ewing, Andrew
    An in situ fracture device to image lipids in single cells using TOF-SIMS2011In: Surface and Interface Analysis, Vol. 43, no 1-2, p. 257-260Article in journal (Refereed)
  • 98.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Chemical characterisation of different separation media based on agarose by static time-of-flight secondary ion mass spectrometry2004In: Journal of Chromatography A, Vol. 1023, no 1023, p. 49-56Article in journal (Refereed)
  • 99.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Chemical characterization of combusion deposits by TOF-SIMS2001Conference paper (Other academic)
  • 100.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Mass spectrometric imaging of lipids in brain tissue2004In: Anal. Chem, Vol. 76, p. 4271-4278Article in journal (Refereed)
123 51 - 100 of 118
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