Change search
Refine search result
7891011 451 - 500 of 545
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 451. Silén, J
    et al.
    Cottin, H
    Hilchenbach, M
    Kissel, J
    Lehto, H
    Siljeström, Sandra
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    COSIMA data analysis using multivariate techniques2014In: Geoscientific Instrumentation, Methods and Data Systems, ISSN 2193-0856, E-ISSN 2193-0864, Vol. 4, p. 455-489Article in journal (Refereed)
    Abstract [en]

    We describe how to use multivariate analysis of complex TOF-SIMS spectra introducing the method of random projections. The technique allows us to do full clustering and classification of the measured mass spectra. In this paper we use the tool for classification purposes. The presentation describes calibration experiments of 19 minerals on Ag and Au substrates using positive mode ion spectra. The discrimination between individual minerals gives a crossvalidation Cohen κ for classification of typically about 80%. We intend to use the method as a fast tool to deduce a qualitative similarity of measurements.

  • 452. Simonsson, L
    et al.
    Gunnarsson, Anders
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Wallin, P
    Jönsson, P
    Höök, F
    Continuous Lipid Bilayers Derived from Cell Membranes for Spatial Molecular Manipulation2011In: Journal of the American Chemical Society, Vol. 133, p. 14027–14032-Article in journal (Refereed)
  • 453. Sivertsen, A
    et al.
    Isaksson, J
    Leiros, Hanna-Kirsti S
    Svenson, Johan
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Svendsen, JS
    Brandsdal, BO
    Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin2014In: BMC Structural Biology, ISSN 1472-6807, E-ISSN 1472-6807, Vol. 14, no 1, article id Art nr 4Article in journal (Refereed)
    Abstract [en]

    Background Many biologically active compounds bind to plasma transport proteins, and this binding can be either advantageous or disadvantageous from a drug design perspective. Human serum albumin (HSA) is one of the most important transport proteins in the cardiovascular system due to its great binding capacity and high physiological concentration. HSA has a preference for accommodating neutral lipophilic and acidic drug-like ligands, but is also surprisingly able to bind positively charged peptides. Understanding of how short cationic antimicrobial peptides interact with human serum albumin is of importance for developing such compounds into the clinics. Results The binding of a selection of short synthetic cationic antimicrobial peptides (CAPs) to human albumin with binding affinities in the μM range is described. Competitive isothermal titration calorimetry (ITC) and NMR WaterLOGSY experiments mapped the binding site of the CAPs to the well-known drug site II within subdomain IIIA of HSA. Thermodynamic and structural analysis revealed that the binding is exclusively driven by interactions with the hydrophobic moieties of the peptides, and is independent of the cationic residues that are vital for antimicrobial activity. Both of the hydrophobic moieties comprising the peptides were detected to interact with drug site II by NMR saturation transfer difference (STD) group epitope mapping (GEM) and INPHARMA experiments. Molecular models of the complexes between the peptides and albumin were constructed using docking experiments, and support the binding hypothesis and confirm the overall binding affinities of the CAPs. Conclusions The biophysical and structural characterizations of albumin-peptide complexes reported here provide detailed insight into how albumin can bind short cationic peptides. The hydrophobic elements of the peptides studied here are responsible for the main interaction with HSA. We suggest that albumin binding should be taken into careful consideration in antimicrobial peptide studies, as the systemic distribution can be significantly affected by HSA interactions.

  • 454.
    Sjögren, Torsten
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Hållfasthet (BMh).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Snis, Anders
    Engqvist, Håkan
    Karlsson, Joakim
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Digital image correlation analysis of local strain fields on Ti6A14V manufactured by electron beam melting2014In: Materials Science & Engineering A, Vol. 618, p. 456-461Article in journal (Other academic)
  • 455.
    Sjöstrand, Karin
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Färghärdighet vid industritvätt1988Report (Refereed)
  • 456.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Carlred, Louise
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Liposome binding for multiplexed biomolecule detection and imaging using ToF-SIMS2014In: Surface and Interface Analysis, ISSN 0142-2421, E-ISSN 1096-9918, Vol. 46, no 10-11, p. 707-711Article in journal (Refereed)
    Abstract [en]

    A novel approach for multiplexed biomolecule detection at surfaces, involving specific binding of liposomes and subsequent analysis by time-of-flight secondary ion mass spectrometry (ToF-SIMS), was evaluated with respect to its capability for quantitative analysis of biomolecule surface concentrations. The specific binding of liposomes to a poly(L-lysine)-g-poly (ethylene glycol) (PLL-g-PEG) surface, using the biotin-avidin coupling chemistry, was characterized by quartz crystal microbalance with dissipation monitoring (QCM-D), fluorescence microscopy and ToF-SIMS. The ToF-SIMS results showed a linearly increasing signal from the liposomes up to a saturation coverage corresponding to a full liposome layer on the surface, in close agreement with fluorescence microscopy analysis of the same samples, strongly supporting the potential of the liposome-based approach for quantitative biomolecule detection. However, the multiplexing capability and issues on nonspecific binding need further studies. Furthermore, an improved method for the preparation of lipid bilayer samples for ToF-SIMS analysis is presented, demonstrating the imaging of individual 210-nm diameter liposomes adsorbed on a SiO2 surface.

  • 457.
    Sjövall, Peter
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Petronis, Sarunas
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro2014In: International Journal of Nanomedicine, ISSN 1176-9114, E-ISSN 1178-2013, Vol. 9, no 1, p. 2499-2515Article in journal (Refereed)
    Abstract [en]

    Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role inthe osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Results: We found that the proliferation and osteogenicdifferentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.

  • 458.
    Skedung, Lisa
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science. KTH Royal Institute of Technology, Sweden.
    Buraczewska-Norin, Izabela
    Omega Pharma Nordic, Sweden.
    Dawood, Nagum
    Omega Pharma Nordic, Sweden; Uppsala University, Sweden.
    Rutland, Mark W.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science. KTH Royal Institute of Technology, Sweden.
    Ringstad, Lovisa
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Tactile friction of topical formulations2016In: Skin research and technology, ISSN 0909-752X, E-ISSN 1600-0846, Vol. 22, no 1, p. 46-54Article in journal (Refereed)
    Abstract [en]

    Background: The tactile perception is essential for all types of topical formulations (cosmetic, pharmaceutical, medical device) and the possibility to predict the sensorial response by using instrumental methods instead of sensory testing would save time and cost at an early stage product development. Here, we report on an instrumental evaluation method using tactile friction measurements to estimate perceptual attributes of topical formulations. Methods: Friction was measured between an index finger and an artificial skin substrate after application of formulations using a force sensor. Both model formulations of liquid crystalline phase structures with significantly different tactile properties, as well as commercial pharmaceutical moisturizing creams being more tactile-similar, were investigated. Friction coefficients were calculated as the ratio of the friction force to the applied load. The structures of the model formulations and phase transitions as a result of water evaporation were identified using optical microscopy. Results: The friction device could distinguish friction coefficients between the phase structures, as well as the commercial creams after spreading and absorption into the substrate. In addition, phase transitions resulting in alterations in the feel of the formulations could be detected. A correlation was established between skin hydration and friction coefficient, where hydrated skin gave rise to higher friction. Also a link between skin smoothening and finger friction was established for the commercial moisturizing creams, although further investigations are needed to analyse this and correlations with other sensorial attributes in more detail. Conclusion: The present investigation shows that tactile friction measurements have potential as an alternative or complement in the evaluation of perception of topical formulations.

  • 459.
    Skedung, Lisa
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Ringstad, Lovisa
    Rutland, Mark
    Tactile friction of topical formulations2013In: 5th World Tribology Congress, WTC 2013, 2013, , p. 2249-2251Conference paper (Refereed)
  • 460.
    Skedung, Lisa
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Rutland, Mark
    RISE, SP – Sveriges Tekniska Forskningsinstitut.
    Feeling small: Exploring the tactile perception limits2013In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 3, p. 2617-Article in journal (Refereed)
  • 461.
    Skedung, Lisa
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Rutland, Mark
    Tribology, texture and touch2013In: 5th World Tribology Congress, WTC 2013, 2013, , p. 2270-2273Conference paper (Refereed)
  • 462.
    Skoglund, Pål
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Vikstrand, Erik
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Undersökning av luftburna partiklar med hjälp av svepelektronmikroskopi1996Report (Refereed)
  • 463.
    Solstad, Runar Gjerp
    et al.
    UiT The Arctic University of Norway, Norway.
    Li, Chun
    UiT The Arctic University of Norway, Norway.
    Isaksson, Johan
    UiT The Arctic University of Norway, Norway.
    Johansen, Jostein
    UiT The Arctic University of Norway, Norway.
    Svenson, Johan
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. UiT The Arctic University of Norway, Norway.
    Stensvåg, Klara
    UiT The Arctic University of Norway, Norway.
    Haug, Tor
    UiT The Arctic University of Norway, Norway.
    Novel antimicrobial peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible sea urchin Echinus esculentus have 6-br-trp post-translational modifications2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 3, article id e0151820Article in journal (Refereed)
    Abstract [en]

    The global problem of microbial resistance to antibiotics has resulted in an urgent need to develop new antimicrobial agents. Natural antimicrobial peptides are considered promising candidates for drug development. Echinoderms, which rely on innate immunity factors in the defence against harmful microorganisms, are sources of novel antimicrobial peptides. This study aimed to isolate and characterise antimicrobial peptides from the Edible sea urchin Echinus esculentus. Using bioassay-guided purification and cDNA cloning, three antimicrobial peptides were characterised from the haemocytes of the sea urchin; two heterodimeric peptides and a cysteine-rich peptide. The peptides were named EeCentrocin 1 and 2 and EeStrongylocin 2, respectively, due to their apparent homology to the published centrocins and strongylocins isolated from the green sea urchin Strongylocentrotus droebachiensis. The two centrocin-like peptides EeCentrocin 1 and 2 are intramolecularly connected via a disulphide bond to form a heterodimeric structure, containing a cationic heavy chain of 30 and 32 amino acids and a light chain of 13 amino acids. Additionally, the light chain of EeCentrocin 2 seems to be N-terminally blocked by a pyroglutamic acid residue. The heavy chains of EeCentrocins 1 and 2 were synthesised and shown to be responsible for the antimicrobial activity of the natural peptides. EeStrongylocin 2 contains 6 cysteines engaged in 3 disulphide bonds. A fourth peptide (Ee4635) was also discovered but not fully characterised. Using mass spectrometric and NMR analyses, EeCentrocins 1 and 2, EeStrongylocin 2 and Ee4635 were all shown to contain post-translationally brominated Trp residues in the 6 position of the indole ring.

  • 464.
    Sommertune, Jens
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Sugunan, Abhilash
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Ahniyaz, Anwar
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Stjernberg Bejhed, Rebecca
    Uppsala University, Sweden.
    Sarwe, Anna
    RISE, Swedish ICT, Acreo.
    Johansson, Christer
    RISE, Swedish ICT, Acreo.
    Balceris, Cristoph
    Technische Universität Braunschweig, Germany.
    Ludwig, Frank
    Technische Universität Braunschweig, Germany.
    Posth, Oliver
    PTB Physikalisch-Technische Bundesanstalt, Germany.
    Fornara, Andrea
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Polymer/iron oxide nanoparticle composites—A straight forward and scalable synthesis approach2015In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 16, no 8, p. 19752-19768Article in journal (Refereed)
    Abstract [en]

    Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

  • 465.
    Sott, K
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Eriksson, E
    Acquisition of single cell data in an optical microscope: Chapter 92009In: Lab on a Chip Technology: Biomolecular Separation and Analysis / [ed] Keith E. Herold and Avraham Rasooly, Caister Academic Press, 2009, p. 151-Chapter in book (Refereed)
  • 466.
    Sott, Richard
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Löfkvist, Klara
    RISE, SP – Sveriges Tekniska Forskningsinstitut, JTI Institutet för Jordbruks- och Miljöteknik.
    Förstudie om nästa generations skyddsutrustning för kemikalieexponering i växthus2015Report (Other academic)
    Abstract [sv]

    För att kunna klara en säker produktion i växthus används kemiska växtskyddsmedel mot olika typer av patogener (svampar och insekter). Dessutom används retarderingmedel för att styra plantans tillväxt och skapa en lönsam produktion. De som utför den kemiska växtskyddsåtgärden är utbildade, har behörighet och använder i viss utsträckning skyddsutrustning.1-3 Däremot de som jobbar i växthuset efter utförd behandling är många gånger helt oskyddade. Exponeringsstudier gjorda på upptag av retarderingsmedlet Cycocel (Klormekvatklorid) visar att de som jobbar i växthus med cycocelbehandlade plantor har rester av cycocel i sin urin.4 Då växtskyddsmedel appliceras är det viktigt att alla plantor täcks väl och den rikliga besprutningen medför att även inerta ytor såsom bord, vävar och krukor i växthuset kontamineras. Hur nedbrytningen av kemikalierna ser ut på dessa ytor är idag inte känt. Det är dock tydligt att personal i växthus exponeras för och får i sig kemikalier under sitt arbete och det är oklart hur skadligt detta är för den enskilda individen. Den stora utmaningen då det gäller skyddsutrustning i växthus är att hitta ett material som är praktiskt, bekvämt och funktionellt även vid hög temperatur (25-35°C) och luftfuktighet under en hel arbetsdag. För att kunna komma till botten med detta utvärderas exponeringsvägen genom att studera hur växthuspersonalen utsätts för dessa kemikalier, och vilka olika skyddsmaterial som ger tillräckligt skydd.

  • 467.
    Spetz, Göran
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Nilsson, Karin
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Elfman, Göran
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Comparison of soft thermoplastic elastomers with vulcanized rubbers.1988Report (Refereed)
  • 468.
    Spilg, Leo
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Unscreened low tension cables scrape abrasion testing. Part 1. An interlaboratory study on scrape abrasion testing according to ISO DP 6722-1.1992Report (Refereed)
  • 469. Stenler, S
    et al.
    Wiklander, O P B
    Badal-Tejedor, Maria
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Turunen, J
    Nordin, J
    Hallengard, D
    Micro-minicircle gene therapy: Implications of size on fermentation, complexation, shearing resistance, and expression2013In: Molecular Therapy - Nucleic Acids, ISSN 2162-2531, E-ISSN 2162-2531, Vol. 2, article id art nr e140Article in journal (Refereed)
    Abstract [en]

    The minicircle (MC), composed of eukaryotic sequences only, is an interesting approach to increase the safety and efficiency of plasmid-based vectors for gene therapy. In this paper, we investigate micro-MC (miMC) vectors encoding small regulatory RNA. We use a construct encoding a splice-correcting U7 small nuclear RNA, which results in a vector of 650 base pairs (bp), as compared to a conventional 3600 bp plasmid carrying the same expression cassette. Furthermore, we construct miMCs of varying sizes carrying different number of these cassettes. This allows us to evaluate how size influences production, supercoiling, stability and efficiency of the vector. We characterize coiling morphology by atomic force microscopy and measure the resistance to shearing forces caused by an injector device, the Biojector. We compare the behavior of miMCs and plasmids in vitro using lipofection and electroporation, as well as in vivo in mice. We here show that when the size of the miMC is reduced, the formation of dimers and trimers increases. There seems to be a lower size limit for efficient expression. We demonstrate that miMCs are more robust than plasmids when exposed to shearing forces, and that they show extended expression in vivo.

  • 470.
    Stenlund, Patrik
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Healing of complement activating Ti implants compared with non-activating Ti in rat tibia2012In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 8, no 9, p. 3532-3540Article in journal (Refereed)
  • 471.
    Stenlund, Patrik
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. University of Gothenburg, Sweden.
    Kurosu, Shingo
    Tohoku University, Japan.
    Koizumi, Yuichiro
    Tohoku University, Japan.
    Suska, Felicia
    University of Gothenburg, Sweden.
    Matsumoto, Hiroaki
    Tohoku University, Japan.
    Chiba, Akihiko
    Tohoku University, Japan.
    Palmquist, Anders
    University of Gothenburg, Sweden.
    Osseointegration Enhancement by Zr doping of Co-Cr-Mo Implants Fabricated by Electron Beam Melting2015In: Additive Manufacturing, ISSN 2214-8604, Vol. 6, p. 6-15Article in journal (Refereed)
    Abstract [en]

    Direct osseous healing to prosthetic components is a prerequisite for the clinical success of uncemented treatment in total hip replacements (THR). The demands imposed on the material properties are constantly being stepped up to withstand the impact of an active lifestyle and ensure lifelong integration. Cobalt–chromium–molybdenum (Co-Cr-Mo) materials are interesting for their excellent mechanical stability, corrosion resistance and possibility to be produced by additive manufacturing into complex designs with modifiable stiffness. The bone response to Co-Cr-Mo is regarded as inferior to that of titanium and are usually cemented in THR. The hypothesis in the present study was that a low amount of Zr in the Co-Cr-Mo alloy would improve the bone response and biomechanical anchorage. The results showed significantly higher implant stability for the Co-Cr-Mo alloy with an addition of 0.04% Zr after eight weeks of healing in rabbits, while no major differences were observed in the amount of bone formed around the implants. Further, bone tissue grew into surface irregularities and in direct contact with the implant surfaces. It is concluded that additively manufactured Co-Cr-Mo alloy implants osseointegrate and that the addition of a low amount of Zr to the bulk Co-Cr-Mo further improves the bone anchorage.

  • 472.
    Stenlund, Patrik
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. University of Gothenburg, Sweden.
    Omar, Omar
    University of Gothenburg, Sweden.
    Brohede, Ulrika
    University of Gothenburg, Sweden; Sandvik Coromant R&D, Sweden.
    Norgren, Susanne
    University of Gothenburg, Sweden; Sandvik Coromant R&D, Sweden; Uppsala University, Sweden.
    Norlindh, Birgitta
    University of Gothenburg, Sweden.
    Johansson, Anna
    University of Gothenburg, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf). University of Gothenburg, Sweden.
    Thomsen, Peter
    University of Gothenburg, Sweden.
    Palmquist, Anders
    University of Gothenburg, Sweden.
    Bone response to a novel Ti-Ta-Nb-Zr alloy2015In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 20, p. 165-175Article in journal (Refereed)
    Abstract [en]

    Commercially pure titanium (cp-Ti) is regarded as the state-of-the-art material for bone-anchored dental devices, whereas the mechanically stronger alloy (Ti–6Al–4V), made of titanium, aluminum (Al) and vanadium (V), is regarded as the material of choice for high-load applications. There is a call for the development of new alloys, not only to eliminate the potential toxic effect of Al and V but also to meet the challenges imposed on dental and maxillofacial reconstructive devices, for example. The present work evaluates a novel, dual-stage, acid-etched, Ti–Ta–Nb–Zr alloy implant, consisting of elements that create low toxicity, with the potential to promote osseointegration in vivo. The alloy implants (denoted Ti–Ta–Nb–Zr) were evaluated after 7 days and 28 days in a rat tibia model, with reference to commercially pure titanium grade 4 (denoted Ti). Analyses were performed with respect to removal torque, histomorphometry and gene expression. The Ti–Ta–Nb–Zr showed a significant increase in implant stability over time in contrast to the Ti. Further, the histological and gene expression analyses suggested faster healing around the Ti–Ta–Nb–Zr, as judged by the enhanced remodeling, and mineralization, of the early-formed woven bone and the multiple positive correlations between genes denoting inflammation, bone formation and remodeling. Based on the present experiments, it is concluded that the Ti–Ta–Nb–Zr alloy becomes osseointegrated to at least a similar degree to that of pure titanium implants. This alloy is therefore emerging as a novel implant material for clinical evaluation.

  • 473.
    Stensen, Wenche
    et al.
    UiT The Arctic University of Norway, Norway; Lytix Biopharma AS, Norway.
    Turner, Rob
    MedPharm Ltd, UK.
    Brown, Marc
    MedPharm Ltd, UK; University of Hertfordshire, UK.
    Kondori, Nahid
    University of Gothenburg, Sweden.
    Svendsen, John Sigurd
    UiT The Arctic University of Norway, Norway; Lytix Biopharma AS, Norway.
    Svenson, Johan
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Short cationic antimicrobial peptides display superior antifungal activities toward Candidiasis and Onychomycosis in comparison with Terbinafine and Amorolfine2016In: Molecular Pharmaceutics, ISSN 1543-8384, E-ISSN 1543-8392, Vol. 13, no 10, p. 3595-3600Article in journal (Refereed)
    Abstract [en]

    Novel antifungals are in high demand due to the challenges associated with resistant, persistent, and systemic fungal infections. Synthetic mimics of antimicrobial peptides are emerging as a promising class of compounds for antifungal treatment. In the current study, five synthetic cationic antimicrobial tripeptides were evaluated as antifungal therapeutics against 24 pathogenic strains of fungi. Three of the peptides displayed strong general antifungal properties at low micromolar inhibitory concentrations. The most promising peptide, compound 5, was selected and evaluated as an antifungal remedy for Candida albicans candidiasis in a human skin model and for the treatment of Trichophyton rubrum induced onychomycosis in an infected human nail model. Compound 5 was shown to display antifungal properties and a rapid mode of action superior to those of both the commercial comparators Loceryl and Lamisil. Compound 5 was also active against a clinical isolate of Candida albicans with acquired fluconazole resistance.

  • 474.
    Stepien, M.
    et al.
    Åbo Akademi University, Finland.
    Chinga-Carrasco, Gary
    RISE, Innventia, PFI – Paper and Fiber Research Institute.
    Saarinen, J. J.
    Åbo Akademi University, Finland.
    Teisala, H.
    Tampere University of Technology, Finland.
    Tuominen, Mikko
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Haapanen, J.
    Tampere University of Technology, Finland.
    Kuusipalo, J.
    Tampere University of Technology, Finland.
    Mäkelä, J. M.
    Tampere University of Technology, Finland.
    Toivakka, M.
    Åbo Akademi University, Finland.
    Abrasion and compression resistance of liquid-flame-spray-deposited functional nanoparticle coatings on paper2014In: 13th TAPPI Advanced Coating Fundamentals Symposium 2014, TAPPI Press, 2014, p. 68-82Conference paper (Refereed)
    Abstract [en]

    • Liquid flame spray technology enables low-cost, large-scale nanoparticle deposition in roll-to-roll processes for controlling wettability and creating functional surfaces • SiO2 nanocoating has higher abrasion resistance than TiO2 coating, possibly due to better interparticle sintering • Wettability properties of the LFS nanoparticle coated paperboard are partially maintained after abrasion with a paper surface or compression through calendering • The changes in wettability are due to smoothening of the nanoparticle surface Changes in wettability properties during transport and in converting operations can be expected to be small • Challenges: - Nanoparticle release to air and safety aspects are unknown and difficult to quantify • Potential applications: - Printability control - Improved barrier and heat-sealing properties for extrusion coated board - Adhesion promotion in converting - Liquid absorption control in papermaking and converting operations - Functional surfaces, e.g., self-cleaning surfaces - Printed electronics applications - Microfluidics.

  • 475.
    Stepien, M.
    et al.
    Åbo Akademi University, Finland.
    Chinga-Carrasco, Gary
    RISE, Innventia, PFI – Paper and Fiber Research Institute.
    Saarinen, J.J
    Åbo Akademi University, Finland.
    Teisala, H.
    Tampere University of Technology, Finland.
    Tuominen, M.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Haapanen, J.
    Tampere University of Technology, Finland.
    Kuusipalo, J.
    Tampere University of Technology, Finland.
    Abrasion and Compression Resistance of Liquid-Flame-Spray-Deposited Functional Nanoparticle Coatings on Paper2014Conference paper (Refereed)
    Abstract [en]

    Functional paper surfaces with adjustable wettability can be fabricated by deposition of nanoparticles in a roll-to-roll liquid flame spray (LFS) process. The TiO2 nanoparticle coating creates a superhydrophobic surface with water CAs exceeding 160°, whereas SiO2 nanoparticle coating creates highly hydrophilic surfaces with water CAs as low as 21°. The superhydrophobicity or hydrophilicity is a result of the combined effect of surface structure and surface chemistry of the nanoparticles. Furthermore, the wettability of the TiO2-nanoparticle coated paper can controlled photocatalytically and adjusted with UV-treatment to any water contact angle between 10° to 160°. In the current work, the abrasion and compression resistance of LFS nanoparticle coated paper was investigated with rotary abrasion testing and calendering. Changes in sample properties were analysed with contact angle measurements, atomic force microscopy and high resolution field-emission scanning electron microscopy (FESEM).

  • 476.
    Sundahl, Mikael
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Effects of short-lived and reactive compounds on Indoor air quality: A study on the formation of peroxyacetylnitrate from O3, NO2 and organic precursors1999In: Proceedings of the 8th International Conference on Indoor Air Quality and Climate. Indoor Air '99, Edinburgh, Scotland, 8-13 August 1999, Construction Research Communications , 1999Conference paper (Other academic)
  • 477.
    Sundahl, Mikael
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Spridning av PCB från PCB-haltiga fogmassor till angränsande byggmaterial. Provtagningar, analyser och utvärdering.2001Report (Refereed)
  • 478.
    Svagan, Anna J.
    et al.
    KTH Royal Institute of Technology, Sweden; University of Copenhagen, Denmark.
    Benjamins, Jan-Willem
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Al-Ansari, Zeinab
    University of Copenhagen, Denmark.
    Shalom, Daniel Bar
    University of Copenhagen, Denmark.
    Müllertz, Anette
    University of Copenhagen, Denmark.
    Wågberg, Lars
    KTH Royal Institute of Technology, Sweden.
    Löbmann, Korbinian
    University of Copenhagen, Denmark.
    Solid cellulose nanofiber based foams – Towards facile design of sustained drug delivery systems2016In: Journal of Controlled Release, ISSN 0168-3659, E-ISSN 1873-4995, Vol. 244, p. 74-82Article in journal (Refereed)
    Abstract [en]

    Control of drug action through formulation is a vital and very challenging topic within pharmaceutical sciences. Cellulose nanofibers (CNF) are an excipient candidate in pharmaceutical formulations that could be used to easily optimize drug delivery rates. CNF has interesting physico-chemical properties that, when combined with surfactants, can be used to create very stable air bubbles and dry foams. Utilizing this inherent property, it is possible to modify the release kinetics of the model drug riboflavin in a facile way. Wet foams were prepared using cationic CNF and a pharmaceutically acceptable surfactant (lauric acid sodium salt). The drug was suspended in the wet-stable foams followed by a drying step to obtain dry foams. Flexible cellular solid materials of different thicknesses, shapes and drug loadings (up to 50 wt%) could successfully be prepared. The drug was released from the solid foams in a diffusion-controlled, sustained manner due to the presence of intact air bubbles which imparted a tortuous diffusion path. The diffusion coefficient was assessed using Franz cells and shown to be more than one order of magnitude smaller for the cellular solids compared to the bubble-free films in the wet state. By changing the dimensions of dry foams while keeping drug load and total weight constant, the drug release kinetics could be modified, e.g. a rectangular box-shaped foam of 8 mm thickness released only 59% of the drug after 24 h whereas a thinner foam sample (0.6 mm) released 78% of its drug content within 8 h. In comparison, the drug release from films (0.009 mm, with the same total mass and an outer surface area comparable to the thinner foam) was much faster, amounting to 72% of the drug within 1 h. The entrapped air bubbles in the foam also induced positive buoyancy, which is interesting from the perspective of gastroretentive drug-delivery.

  • 479.
    Svenson, Johan
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    På jakt efter nya läkemedel i Ishavet2016In: Naturvetare, ISSN 2000-2424, Vol. 6, p. 24-28Article in journal (Other (popular science, discussion, etc.))
    Abstract [sv]

    Ungefär en tredjedel av alla läkemedel har sin källa i naturen. Forskaren Johan Svenson skriver själv om sin expedition i Arktis, där forskarna samlar in alger och andra organismer i sökandet efter nya molekyler, som till exempel kan bli ny antibiotika.

  • 480.
    Svensson, C. R.
    et al.
    Lund University, Sweden.
    Ameer, S. S.
    Lund University, Sweden.
    Ludvigsson, L.
    Lund University, Sweden.
    Ali, N.
    Lund University, Sweden.
    Alhamdow, A.
    Lund University, Sweden; Karolinska Institute, Sweden.
    Messing, M. E.
    Lund University, Sweden.
    Pagels, J.
    Lund University, Sweden.
    Gudmundsson, A.
    Lund University, Sweden.
    Bohgard, M.
    Lund University, Sweden.
    Sanfins, E.
    Institute of Emerging Diseases and Innovative Therapies, France.
    Kåredal, M.
    Lund University, Sweden.
    Broberg, K.
    Lund University, Sweden; Karolinska Institute, Sweden.
    Rissler, Jenny
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor. Lund University, Sweden.
    Validation of an air–liquid interface toxicological set-up using Cu, Pd, and Ag well-characterized nanostructured aggregates and spheres2016In: Journal of nanoparticle research, ISSN 1388-0764, E-ISSN 1572-896X, Vol. 18, no 4, article id 86Article in journal (Refereed)
    Abstract [en]

    Systems for studying the toxicity of metal aggregates on the airways are normally not suited for evaluating the effects of individual particle characteristics. This study validates a set-up for toxicological studies of metal aggregates using an air–liquid interface approach. The set-up used a spark discharge generator capable of generating aerosol metal aggregate particles and sintered near spheres. The set-up also contained an exposure chamber, The Nano Aerosol Chamber for In Vitro Toxicity (NACIVT). The system facilitates online characterization capabilities of mass mobility, mass concentration, and number size distribution to determine the exposure. By dilution, the desired exposure level was controlled. Primary and cancerous airway cells were exposed to copper (Cu), palladium (Pd), and silver (Ag) aggregates, 50–150 nm in median diameter. The aggregates were composed of primary particles &lt;10 nm in diameter. For Cu and Pd, an exposure of sintered aerosol particles was also produced. The doses of the particles were expressed as particle numbers, masses, and surface areas. For the Cu, Pd, and Ag aerosol particles, a range of mass surface concentrations on the air–liquid interface of 0.4–10.7, 0.9–46.6, and 0.1–1.4 µg/cm2, respectively, were achieved. Viability was measured by WST-1 assay, cytokines (Il-6, Il-8, TNF-a, MCP) by Luminex technology. Statistically significant effects and dose response on cytokine expression were observed for SAEC cells after exposure to Cu, Pd, or Ag particles. Also, a positive dose response was observed for SAEC viability after Cu exposure. For A549 cells, statistically significant effects on viability were observed after exposure to Cu and Pd particles. The set-up produced a stable flow of aerosol particles with an exposure and dose expressed in terms of number, mass, and surface area. Exposure-related effects on the airway cellular models could be asserted.

  • 481.
    Svensson, Per-Ola
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Mätosäkerhet vid mekanisk provning av polymera materials: Nötning av PVC-mattor1998Report (Refereed)
  • 482.
    Svensson, Sara
    et al.
    University of Gothenburg, Sweden.
    Trobos, Margarita
    University of Gothenburg, Sweden.
    Hoffman, Maria
    University of Gothenburg, Sweden.
    Norlindh, Birgitta
    University of Gothenburg, Sweden.
    Petronis, Sarunas
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Suska, Felicia
    University of Gothenburg, Sweden.
    Thomsen, Peter
    University of Gothenburg, Sweden.
    A novel soft tissue model for biomaterial-associated infection and inflammation - Bacteriological, morphological and molecular observations2015In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 41, p. 106-121Article in journal (Refereed)
    Abstract [en]

    Infection constitutes a major risk for implant failure, but the reasons why biomaterial sites are more vulnerable than normal tissue are not fully elucidated. In this study, a soft tissue infection model was developed, allowing the analysis of cellular and molecular responses in each of the sub-compartments of the implant-tissue interface (on the implant surface, in the surrounding exudate and in the tissue). Smooth and nanostructured titanium disks with or without noble metal chemistry (silver, gold, palladium), and sham sites, were inoculated with Staphylococcus epidermidis and analysed with respect to number of viable bacteria, number, viability and gene expression of host cells, and using different morphological techniques after 4 h, 24 h and 72 h. Non-infected rats were controls. Results showed a transient inflammatory response at control sites, whereas bacterial administration resulted in higher recruitment of inflammatory cells (mainly polymorphonuclear), higher, continuous cell death and higher gene expression of tumour necrosis factor-alpha, interleukin-6, interleukin-8, Toll-like receptor 2 and elastase. At all time points, S. epidermidis was predominantly located in the interface zone, extra- and intracellularly, and lower levels were detected on the implants compared with surrounding exudate. This model allows detailed analysis of early events in inflammation and infection associated to biomaterials in vivo leading to insights into host defence mechanisms in biomaterial-associated infections.

  • 483.
    Swerin, Agne
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    TopNANO - Top-level nanoscale coatings and surface treatment to prevent and combat condensation of water, ice formation, ice growth and adhesion with applications in aircraft, wind turbines and heat exchangers for improved energy efficiency and safety2015Report (Refereed)
  • 484.
    Swerin, Agne
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Claesson, Per
    RISE, SP – Sveriges Tekniska Forskningsinstitut.
    Frictional forces between hydrophilic and hydrophobic particle coated nanostructured surfaces2013In: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 15, no 41, p. 17893-17902Article in journal (Refereed)
  • 485.
    Swerin, Agne
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Sedighi Moghaddam, Maziar
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Claesson, Per
    Report on the Troëdsson Adjunct Professorship in Forest-based Surface Chemistry at KTH financed by the Troëdsson Foundation – reporting period 2013-20142014Report (Refereed)
  • 486.
    Swerin, Agne
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Sundin, Mikael
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Wåhlander, Martin
    KTH Royal Institute of Technology, Sweden.
    Formulation of a pigmented foam aimed for superhydrophobic coatings2015In: Paper Conference and Trade Show (PaperCon 2015), 2015Conference paper (Refereed)
    Abstract [en]

    Fundamental studies of superhydrophobicity have evolved toward several industrial applications. The present study concerns the formulation of pigmented foam aimed for water-borne superhydrophobic surface layers. An industrially viable process for a one-step water-borne superhydrophobic coating was developed in collaboration with industrial partners. A typical formulation contained calcium carbonate (preferably aragonite type), sodium oleate and carboxylic latex binder. The pigmented foam was laboratory rod coated onto paperboard substrates. During the drying the foamed structure collapses into a pigmented coating. The contact and rolling-off angles, droplet stain size and Cobb value were evaluated for different amounts of the added ingredients. The frictional resistance and water vapour permeability was measured for some of the samples.

    More recent results show that through careful reformulation of the coating dispersions these pigmented foams can be prepared at considerably higher solids content, which is of utmost relevance to decrease drying time if implemented in an industrial process. It was also shown that the hydrostatic water resistance (Cobb value) and the mechanical robustness could be substantially improved compared to previous results. Surface spectroscopy data provided an explanation for the increased water resistance.

  • 487.
    Swerin, Agne
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Sundin, Mikael
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Wåhlander, Martin
    KTH Royal Institute of Technology, Sweden.
    Formulation of superhydrophobic pigment coatings2015In: Paper Conference and Trade Show (PaperCon 2015), TAPPI Press, 2015, Vol. 2, p. 1410-1424Conference paper (Refereed)
  • 488.
    Swerin, Agne
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik. KTH Royal Institute of Technology, Sweden.
    Sundin, Mikael
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Wåhlander, Martin
    RISE, SP – Sveriges Tekniska Forskningsinstitut. KTH Royal Institute of Technology, Sweden.
    One-pot waterborne superhydrophobic pigment coatings at high solids with improved scratch and water resistance2016In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, ISSN 0927-7757, E-ISSN 1873-4359, Vol. 495, p. 79-86Article in journal (Refereed)
    Abstract [en]

    A pigment coating was developed to achieve superhydrophobicity in one step from a waterborne formulation containing aragonite calcium carbonate, hydrophobized using sodium oleate, latex binder and cross-linker. Coatings formulated ≤50 mass% and applied to polyethylene coated paperboard substrates displayed typical superhydrophobic features: water contact angles ≥150°, low roll-off angle and low stain sizes, but poor scratch and water resistance as well as foaming issues during preparation. Reformulation at higher solids content significantly improved scratch and water resistance properties. Water rinsing of the dried coatings further increased the water barrier capacity due to reduced surfactant-assisted wetting; findings were corroborated by detailed surface chemistry analyses showing the removal of surface-active components after water rinsing of the dried coatings. A plausible cause for the improved durability is the fact that capillary forces increase exponentially with increasing pigment volume fraction (power law exponent of 2.2) leading to efficient binder coverage during the early stage of pigment coating consolidation.

  • 489.
    Sätmark, B
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Liang, L
    Chemical effects of goethite colloid on the transport of radionuclides through a quartz-packed column1996In: Journal of Contaminant Hydrology, ISSN 0169-7722, E-ISSN 1873-6009, Vol. 21, no 1, p. 231-241Article in journal (Other academic)
  • 490. Tadesse, M
    et al.
    Svenson, J
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Sepčić, K
    Trembleau, L
    Engqvist, M
    Andersen, J H
    Isolation and synthesis of pulmonarin A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria2014In: Journal of natural products (Print), ISSN 0163-3864, E-ISSN 1520-6025, Vol. 77, no 2, p. 364-369Article in journal (Refereed)
    Abstract [en]

    Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that were isolated and characterized from the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast. The structures of natural pulmonarins A and B were tentatively elucidated by spectroscopic methods and later verified by comparison with synthetically prepared material. Both pulmonarins A and B displayed reversible, noncompetitive acetylcholinesterase inhibition comparable to several known natural acetylcholinesterase inhibitiors. Pulmonarin B was the strongest inhibitor, with an inhibition constant (Ki) of 20 μM. In addition to reversible, noncompetitive acetylcholinesterase inhibition, the compounds displayed weak antibacterial activity but no cytotoxicity or other investigated bioactivities.

  • 491.
    Theodorsson, Elvar
    et al.
    Linköping University, Sweden.
    Magnusson, Bertil
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Kemi.
    Allowable bias when monitoring reference change values2015In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 75, no 7, p. 537-538Article in journal (Refereed)
  • 492.
    Thiel, V.
    et al.
    University of Göttingen, Germany.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Ragazzi, E.
    University of Padova, Italy.
    Seyfullah, L. J.
    University of Göttingen, Germany.
    Schmidt, A. R.
    University of Göttingen, Germany.
    Microbe-like inclusions in tree resins and implications for the fossil record of protists in amber2016In: Geobiology, ISSN 1472-4677, E-ISSN 1472-4669, Vol. 14, no 4, p. 364-373Article in journal (Refereed)
    Abstract [en]

    During the past two decades, a plethora of fossil micro-organisms have been described from various Triassic to Miocene ambers. However, in addition to entrapped microbes, ambers commonly contain microscopic inclusions that sometimes resemble amoebae, ciliates, microfungi, and unicellular algae in size and shape, but do not provide further diagnostic features thereof. For a better assessment of the actual fossil record of unicellular eukaryotes in amber, we studied equivalent inclusions in modern resin of the Araucariaceae; this conifer family comprises important amber-producers in Earth history. Using time-of-flight secondary ion mass spectrometry (ToF-SIMS), we investigated the chemical nature of the inclusion matter and the resin matrix. Whereas the matrix, as expected, showed a more hydrocarbon/aromatic-dominated composition, the inclusions contain abundant salt ions and polar organics. However, the absence of signals characteristic for cellular biomass, namely distinctive proteinaceous amino acids and lipid moieties, indicates that the inclusions do not contain microbial cellular matter but salts and hydrophilic organic substances that probably derived from the plant itself. Rather than representing protists or their remains, these microbe-like inclusions, for which we propose the term 'pseudoinclusions', consist of compounds that are immiscible with the terpenoid resin matrix and were probably secreted in small amounts together with the actual resin by the plant tissue. Consequently, reports of protists from amber that are only based on the similarity of the overall shape and size to extant taxa, but do not provide relevant features at light-microscopical and ultrastructural level, cannot be accepted as unambiguous fossil evidence for these particular groups.

  • 493. Thiel, V
    et al.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS): Chapter 5: Principles and practice in the Biogeosciences2014In: Principles and practice of analytical techniques in Geosciences, Royal Society of Chemistry, 2014, p. 122-170Chapter in book (Refereed)
    Abstract [en]

    Time-of-flight secondary ion mass spectrometry (TOF-SIMS) provides chemical information on the outermost molecular layers of sample surfaces without solvent extraction. In TOF-SIMS, a pulsed beam of high-energy ions (primary ions) is scanned over a selected analysis area on the sample. During the primary ion bombardment, neutral and charged particles (secondary ions) are released from the outermost molecular layers of the sample surface. Analysis of the secondary ions in a TOF analyser yields a mass spectral data set that allows the retrospective production of(1) ion images showing the spatial signal intensity distribution from selected ions over the analysis area; (2) mass spectra from the total analysis area; or (3) mass spectra from user-defined regions of interest inside the analysis area. In the so-called static SIMS regime, the primary ions are provided in very short pulses and the analysis is completed before the incoming primary ions damage a significant fraction of the surface. Static TOF-SIMS is therefore capable of providing molecularly specific secondary ions, and thus mass spectra with detailed organic information, which is not possible with other (‘dynamic’) SIMS techniques. In this chapter, we describe the principles of static TOF-SIMS instrumentation and data evaluation, review a number of relevant applications, and discuss the potential of this technique in the biogeosciences, with a focus on organic biomarker applications.

  • 494. Thiel, V.
    et al.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Time-of-flight secondary ion mass spectrometry (TOF-SIMS): Principles and practice in the biogeosciences2014In: Principles and practice of analytical techniques in Geosciences / [ed] Kliti Grice, Royal Society of Chemistry, 2014, no 4, p. 122-170Chapter in book (Refereed)
    Abstract [en]

    Time-of-flight secondary ion mass spectrometry (TOF-SIMS) provides chemical information on the outermost molecular layers of sample surfaces without solvent extraction. In TOF-SIMS, a pulsed beam of high-energy ions (primary ions) is scanned over a selected analysis area on the sample. During the primary ion bombardment, neutral and charged particles (secondary ions) are released from the outermost molecular layers of the sample surface. Analysis of the secondary ions in a TOF analyser yields a mass spectral data set that allows the retrospective production of(1) ion images showing the spatial signal intensity distribution from selected ions over the analysis area; (2) mass spectra from the total analysis area; or (3) mass spectra from user-defined regions of interest inside the analysis area. In the so-called static SIMS regime, the primary ions are provided in very short pulses and the analysis is completed before the incoming primary ions damage a significant fraction of the surface. Static TOF-SIMS is therefore capable of providing molecularly specific secondary ions, and thus mass spectra with detailed organic information, which is not possible with other (‘dynamic’) SIMS techniques. In this chapter, we describe the principles of static TOF-SIMS instrumentation and data evaluation, review a number of relevant applications, and discuss the potential of this technique in the biogeosciences, with a focus on organic biomarker applications.

  • 495. Trepos, R
    et al.
    Pinori, Emiliano
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Jonsson, P R
    Berglin, Mattias
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Svenson, Johan
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Coutinho, R
    Innovative approaches for the development of new copper-free marine antifouling paints2014In: Journal of Ship and Ocean Technology, ISSN 1226-5594, Vol. 9, no 4, p. 7-18Article in journal (Refereed)
  • 496.
    Trepos, Rozenn
    et al.
    University of Portsmouth, UK.
    Cervin, Gunnar
    University of Gothenburg, Sweden.
    Pile, Claire
    University of Portsmouth, UK.
    Pavia, Henrik
    University of Gothenburg, Sweden.
    Hellio, Claire
    University of Western Brittany, France.
    Svenson, Johan
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor. UiT The Arctic University of Norway, Norway.
    Evaluation of cationic micropeptides derived from the innate immune system as inhibitors of marine biofouling2015In: Biofouling (Print), ISSN 0892-7014, E-ISSN 1029-2454, Vol. 31, no 4, p. 393-403Article in journal (Refereed)
    Abstract [en]

    A series of 13 short synthetic amphiphilic cationic micropeptides, derived from the antimicrobial iron-binding innate defence protein lactoferrin, have been evaluated for their capacity to inhibit the marine fouling process. The whole biofouling process was studied and microfouling organisms such as marine bacteria and microalgae were included as well as the macrofouling barnacle Balanus improvisus. In total 19 different marine fouling organisms (18 microfoulers and one macrofouler) were included and both the adhesion and growth of the microfoulers were investigated. It was shown that the majority of the peptides inhibited barnacle cyprid settlement via a reversible nontoxic mechanism, with IC50 values as low as 0.5 μg ml−1. Six peptides inhibited adhesion and growth of microorganisms. Two of these were particularly active against the microfoulers with MIC-values ranging between 0.01 and 1 μg ml−1, which is comparable with the commercial reference antifoulant SeaNine.

  • 497.
    Tuominen, Mikko
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Adjustable wetting of liquid flame spray (LFS) TiO2-nanoparticle coated board: Batch-type versus roll-to-roll stimulation methods2014In: Nordic Pulp & Paper Research Journal, ISSN 0283-2631, E-ISSN 2000-0669, Vol. 29, no 2, p. 271-279Article in journal (Refereed)
  • 498.
    Tuominen, Mikko
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Funktionella ytbeläggningar på trä/ Functional multilayer coatings to improve properties of wood2016Report (Other academic)
    Abstract [sv]

    Report on the Troëdsson Postdoc-project 2013‒2015.

  • 499.
    Tuominen, Mikko
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Teisala, H.
    Tampere University of Technology, Finland.
    Haapanen, J.
    Tampere University of Technology, Finland.
    Aromaa, M.
    Tampere University of Technology, Finland.
    Mäkelä, J. M.
    Tampere University of Technology, Finland.
    Stepien, M.
    Tampere University of Technology, Finland.
    Saarinen, Jarkko J.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor. Åbo Akademi University, Finland .
    Toivakka, M.
    Åbo Akademi University, Finland .
    Kuusipalo, J.
    Tampere University of Technology, Finland.
    Adjustable wetting of liquid flame spray (LFS) TiO2-nanoparticle coated board: Batch-type versus roll-to-roll stimulation methods2014In: Nordic Pulp & Paper Research Journal, ISSN 0283-2631, E-ISSN 2000-0669, Vol. 29, no 2, p. 271-279Article in journal (Refereed)
    Abstract [en]

    Superhydrophobic nanoparticle coating was created on the surface of board using liquid flame spray (LFS). The LFS coating was carried out continuously in ambient conditions without any additional hydrophobization steps. The contact angle of water (CAW) of ZrO2, Al2O3 and TiO2 coating was adjusted reversibly from &gt;150° down to ~10-20° using different stimulation methods. From industrial point of view, the controlled surface wetting has been in focus for a long time because it defines the liquid-solid contact area, and furthermore can enhance the mechanical and chemical bonding on the interface between the liquid and the solid. The used stimulation methods included batch-type methods: artificial daylight illumination and heat treatment and roll-to-roll methods: corona, argon plasma, IR (infra red)- and UV (ultra violet)-treatments. On the contrary to batch-type methods, the adjustment and switching of wetting was done only in seconds or fraction of seconds using roll-to-roll stimulation methods. This is significant in the converting processes of board since they are usually continuous, high volume operations. In addition, the creation of microfluidic patterns on the surface of TiO2 coated board using simple photomasking and surface stimulation was demonstrated. This provides new advantages and possibilities, especially in the field of intelligent printing. Limited durability and poor repellency against low surface tension liquids are presently the main limitations of LFS coatings.

  • 500.
    Tuominen, Mikko
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Teisala, Hannu
    Tampere University of Technology, Finland.
    Haapanen, Janne
    Tampere University of Technology, Finland.
    Mäkelä, Jyrki M.
    Tampere University of Technology, Finland.
    Honkanen, Mari
    Tampere University of Technology, Finland.
    Vippola, Minnamari
    Tampere University of Technology, Finland.
    Bardage, Stig
    Wålinder, Magnus E. P.
    KTH Royal Institute of Technology, Sweden.
    Swerin, Agne
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Superamphiphobic overhang coating on a biobased material2016In: Annual Surface and Materials Chemistry Symposium and Materials for tomorrow (ASMCS 2016), 2016Conference paper (Refereed)
7891011 451 - 500 of 545
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
v. 2.35.8