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  • 1.
    Afshari, Alireza
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor. Chalmers tekniska högskola, Institutionen för installationsteknik.
    Determination of VOC emissions from surface coatings by environmental test chamber measurements1999Doktoravhandling, monografi (Annet vitenskapelig)
  • 2.
    Albinson, B
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Ström, S
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Analys av UV-absorber i billacker med UV-VIS-spektroskopi1995Rapport (Fagfellevurdert)
  • 3.
    Alfredsson, Robert
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Jarl, Marie-Louice
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Bestämning av sammansättning hos PVC-produkter från gamla hus.1999Rapport (Fagfellevurdert)
  • 4.
    Alriksson, Björn
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Processum.
    Eskilsson, Martin
    Holmen, Sweden.
    Johansson, Emma
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Processum.
    Lapidot, Shaul
    Melodea, Israel.
    Norström, Markus
    RISE., SP – Sveriges Tekniska Forskningsinstitut.
    Schultz-Eklund, Ola
    Holmen, Sweden .
    Shkedi, Yoram
    Melodea, Israel.
    Svedberg, Anna
    MoRe Research, Sweden.
    Svensson, Stefan
    MoRe Research, Sweden.
    Swerin, Agne
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Europe’s first pilot facility for cellulose nanocrystals (CNC)2016Inngår i: Annual Surface and Materials Chemistry Symposium and Materials for tomorrow (ASMCS 2016), 2016Konferansepaper (Fagfellevurdert)
  • 5.
    An, Junxue
    et al.
    KTH Royal Institute of Technology, Sweden.
    Liu, Xiaoyan
    KTH Royal Institute of Technology, Sweden.
    Linse, Per
    Lund University, Sweden.
    Dedinaite, Andra
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber. KTH Royal Institute of Technology, Sweden.
    Winnik, Françoise M.
    University of Montreal, Canada; National Institute for Materials Science, Japan.
    Claesson, Per M.
    RISE., SP – Sveriges Tekniska Forskningsinstitut. KTH Royal Institute of Technology, Sweden.
    Tethered Poly(2-isopropyl-2-oxazoline) Chains: Temperature Effects on Layer Structure and Interactions Probed by AFM Experiments and Modeling2015Inngår i: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 31, nr 10, s. 3039-3048Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Thermoresponsive polymer layers on silica surfaces have been obtained by utilizing electrostatically driven adsorption of a cationic–nonionic diblock copolymer. The cationic block provides strong anchoring to the surface for the nonionic block of poly(2-isopropyl-2-oxazoline), referred to as PIPOZ. The PIPOZ chain interacts favorably with water at low temperatures, but above 46 °C aqueous solutions of PIPOZ phase separate as water becomes a poor solvent for the polymer. We explore how a change in solvent condition affects interactions between such adsorbed layers and report temperature effects on both normal forces and friction forces. To gain further insight, we utilize self-consistent lattice mean-field theory to follow how changes in temperature affect the polymer segment density distributions and to calculate surface force curves. We find that with worsening of the solvent condition an attraction develops between the adsorbed PIPOZ layers, and this observation is in good agreement with predictions of the mean-field theory. The modeling also demonstrates that the segment density profile and the degree of chain interpenetration under a given load between two PIPOZ-coated surfaces rise significantly with increasing temperature.

  • 6.
    Andersson, Bo-Lennart
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Klassificering av atmosfärisk korrosivitet med hjälp av referenskuponger av olika metaller. Rekommenderade rutiner.1999Rapport (Fagfellevurdert)
  • 7.
    Andersson, Bo-Lennart
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Carlsson, Bo
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Insamling av miljödata vid Statens Provningsanstalt i Borås.1989Rapport (Fagfellevurdert)
  • 8.
    Andersson, Bo-Lennart
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Carlsson, Bo
    Korrosionsskyddsklassning av oorganiska ytbeläggningar: delrapport NORDTEST projekt 1459-991999Rapport (Fagfellevurdert)
  • 9.
    Andersson, Bo-Lennart
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Carlsson, Bo
    Korrosionsskyddsklassning av organiska ytbeläggningar2000Rapport (Fagfellevurdert)
  • 10. Andersson, J
    et al.
    Stenhamre, H
    Bäckdahl, Henrik
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Gatenholm, P
    Behaviour of human chondrocytes in engineered porous bacterial cellulose scaffolds. J Biomed Mater Res: Part A. 94A2010Inngår i: J Biomed Mater Res: Part A., Vol. 94A, nr 4, s. 1124-1132Artikkel i tidsskrift (Fagfellevurdert)
  • 11. Andon, F T
    et al.
    Kapralov, A A
    Yanamala, N
    Feng, W
    Baygan, A
    Chambers, B J
    Brandner, B. D.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase2013Inngår i: Small, ISSN 1613-6810, E-ISSN 1613-6829, Vol. 9, nr 16, s. 2721-2729Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Eosinophil peroxidase (EPO) is one of the major oxidant-producing enzymes during inflammatory states in the human lung. The degradation of single-walled carbon nanotubes (SWCNTs) upon incubation with human EPO and H2O 2 is reported. Biodegradation of SWCNTs is higher in the presence of NaBr, but neither EPO alone nor H2O2 alone caused the degradation of nanotubes. Molecular modeling reveals two binding sites for SWCNTs on EPO, one located at the proximal side (same side as the catalytic site) and the other on the distal side of EPO. The oxidized groups on SWCNTs in both cases are stabilized by electrostatic interactions with positively charged residues. Biodegradation of SWCNTs can also be executed in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. Biodegradation is proven by a range of methods including transmission electron microscopy, UV-visible-NIR spectroscopy, Raman spectroscopy, and confocal Raman imaging. Thus, human EPO (in vitro) and ex vivo activated eosinophils mediate biodegradation of SWCNTs: an observation that is relevant to pulmonary responses to these materials. Human eosinophil peroxidase (EPO) is able to degrade SWCNTs in vitro in the presence of H2O2. EPO is one of the major oxidant-generating enzymes present in human lungs during inflammatory states. The biodegradation of SWCNTs is evidenced also in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. These results are relevant to potential respiratory exposure to carbon nanotubes.

  • 12.
    Antonsson, Margareta
    et al.
    SP – Sveriges Provnings- och Forskningsinstitut.
    Nilsson, Karin
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Förslag till miljöledningssystem enligt ISO 14001 på del av verksamheten vid sektionen för polymerteknik1996Rapport (Fagfellevurdert)
  • 13.
    Antonsson, Ulf
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    History, presentation and statistics of SP-method 1737 and SP-method 17382000Rapport (Fagfellevurdert)
  • 14.
    Antonsson, Ulf
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Provning av vattentäthet hos anslutning mellan golvbrunn och tätskikt i keramiska golvbeläggningar1998Rapport (Fagfellevurdert)
  • 15.
    Antonsson, Ulf
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Rörelser hos fogar på flygplatser1995Rapport (Fagfellevurdert)
  • 16.
    Antonsson, Ulf
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Jakobowicz, I
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Rapport från besiktningar utförda under februari till april 1997 av fogningar på vägar och flygfält1997Rapport (Fagfellevurdert)
  • 17.
    Antonsson, Ulf
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Jakubowicz, Ignacy
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Rapport från besiktningar utförda under januari - maj 1996 av fogningar på vägar och flygfält1996Rapport (Fagfellevurdert)
  • 18.
    Antonsson, Ulf
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Jakubowicz, Ignacy
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Rapport från besiktningar utförda under våren 1995 av fogningar på vägar och flygfält1995Rapport (Fagfellevurdert)
  • 19.
    Arlotto, Sébastien
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Characterisation and accelerated ageing of PVC materials from old buildings.1999Rapport (Fagfellevurdert)
  • 20.
    Aronsson, B-O
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Lausmaa, J
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Kasemo, B
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Glow-discharge plasma treatment for surface cleaning and modificaiton of metallic biomaterials.1997Inngår i: Journal of Biomedical Materials Research, ISSN 0021-9304, E-ISSN 1097-4636, Vol. 35, nr 1, s. 49-73Artikkel i tidsskrift (Annet vitenskapelig)
  • 21.
    Arrhenius, Karine
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Kemi.
    Brown, Andrew S.
    NPL National Physical Laboratory, UK.
    van der Veen, Adriaan M. H.
    VSL Dutch Metrology Institute, Netherlands.
    Suitability of different containers for the sampling and storage of biogas and biomethane for the determination of the trace-level impurities - A review2016Inngår i: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 902, s. 22-32Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    The traceable and accurate measurement of biogas impurities is essential in order to robustly assess compliance with the specifications for biomethane being developed by CEN/TC408. An essential part of any procedure aiming to determinate the content of impurities is the sampling and the transfer of the sample to the laboratory. Key issues are the suitability of the sample container and minimising the losses of impurities during the sampling and analysis process. In this paper, we review the state-of-the-art in biogas sampling with the focus on trace impurities. Most of the vessel suitability studies reviewed focused on raw biogas. Many parameters need to be studied when assessing the suitability of vessels for sampling and storage, among them, permeation through the walls, leaks through the valves or physical leaks, sorption losses and adsorption effects to the vessel walls, chemical reactions and the expected initial concentration level. The majority of these studies looked at siloxanes, for which sampling bags, canisters, impingers and sorbents have been reported to be fit-for-purpose in most cases, albeit with some limitations. We conclude that the optimum method requires a combination of different vessels to cover the wide range of impurities commonly found in biogas, which have a wide range of boiling points, polarities, water solubilities, and reactivities. The effects from all the parts of the sampling line must be considered and precautions must be undertaken to minimize these effects. More practical suitability tests, preferably using traceable reference gas mixtures, are needed to understand the influence of the containers and the sampling line on sample properties and to reduce the uncertainty of the measurement.

  • 22.
    Arrhenius, Karine
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Organisk kemi (Kmo).
    Kühnemuth, Daniel
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Kemi.
    Traceable reference gas mixtures for sulfur-free natural gas odorants2014Inngår i: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 13, nr 1, s. 6695-6702Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The first reference gas mixtures of sulfur-free natural gas odorants that are traceable to the International System of Units (SI) have been produced and their compositions validated. These mixtures, which contain methyl acrylate and ethyl acrylate at amount fractions between 1.1 and 2.1 μmol mol-1, can be used to underpin measurements of sulfur-free odorants, which are increasingly being used to odorize natural gas in transmission networks as they have less harmful properties than traditional sulfur-containing odorants. The reference gas mixtures produced have been shown to be stable in passivated aluminum cylinders for at least 8 months and have been validated (to within 6% or less) by interlaboratory measurements at three National Measurement Institutes. The stability of methyl acrylate and ethyl acrylate in gas sampling bags has been investigated, and the challenges of analyzing 2-ethyl-3- methylpyrazine, which is used as a stabilizer in sulfur-free odorants, are also briefly discussed.

  • 23.
    Arrhenius, Karine
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Podien, Doris
    RISE., SP – Sveriges Tekniska Forskningsinstitut.
    Yaghooby, Haleh
    RISE., SP – Sveriges Tekniska Forskningsinstitut.
    Smajovic, Nijaz
    RISE., SP – Sveriges Tekniska Forskningsinstitut.
    Optimization of an Analytical Method for the Measurement of Oil Carryover from a Compressor in Compressed Natural Gas Refueling Stations2015Inngår i: Energy & Fuels, ISSN 0887-0624, E-ISSN 1520-5029, Vol. 29, nr 4, s. 2416-2421Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aims of the study were to determine the best method for extracting oil absorbed on coalescing filters at compressed natural gas (CNG) refueling stations and to compare the mass spectrometer (MS) and flame ionization detector (FID) for the quantification of the oil recovered in the extracts. Dichloromethane and heptane as solvents gave slightly higher recovery yields than pentane. The preferred extraction method with regard to time and solvent consumption consisted of an ultrasonic extraction, followed by removal of the remaining solvent under a stream of nitrogen. The FID and MS were found to be equally suitable for quantifying oil carryover, if the sample only contained the target oil when the instruments of analysis have been properly calibrated. If the sample is contaminated by compounds other than the target oil, MS and FID will provide different valuable information: MS may give information on the structure of the contaminants, while FID will give a more reliable quantification without proper calibration. The work discusses issues with the reusability of the filters and how to handle the memory effects

  • 24.
    Arvidson, Magnus
    et al.
    Brandteknik, skydd (BRs ).
    Bäckman, Anna
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Hedlund, Hans-Peter
    Källqvist, Sofia
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Påverkan av vatten från sprinkler på vägg- och takmålningar2007Rapport (Fagfellevurdert)
  • 25.
    Arvidson, Magnus
    et al.
    Brandteknik, skydd (BRs ).
    Månsson, Margret
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Utvärdering av olika frysskyddsmedel för sprinklersystem. Brandforsk projekt 631-9611999Rapport (Fagfellevurdert)
  • 26.
    Badal Tejedor, Maria
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor. KTH Royal Institute of Technology, Sweden.
    Nordgren, Niklas
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Schuleit, Michael
    Novartis Pharma AG, Switzerland.
    Rutland, Mark W.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor. KTH Royal Institute of Technology, Sweden.
    Millqvist-Fureby, Anna
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Tablet mechanics depend on nano and micro scale adhesion, lubrication and structure2015Inngår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 486, nr 1-2, s. 315-323Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Tablets are the most convenient form for drug administration. However, despite the ease of manufacturing problems such as powder adhesion occur during the production process. This study presents surface and structural characterization of tablets formulated with commonly used excipients (microcrystalline cellulose (MCC), lactose, mannitol, magnesium (Mg) stearate) pressed under different compaction conditions. Tablet surface analyses were performed with scanning electron microscopy (SEM), profilometry and atomic force microscopy (AFM). The mechanical properties of the tablets were evaluated with a tablet hardness test. Local adhesion detected by AFM decreased when Mg stearate was present in the formulation. Moreover, the tablet strength of plastically deformable excipients such as MCC was significantly decreased after addition of Mg stearate. Combined these facts indicate that Mg stearate affects the particle-particle bonding and thus elastic recovery. The MCC excipient also displayed the highest hardness which is characteristic for a highly cohesive material. This is discussed in the view of the relatively high adhesion found between MCC and a hydrophilic probe at the nanoscale using AFM. In contrast, the tablet strength of brittle materials like lactose and mannitol is unaffected by Mg stearate. Thus fracture occurs within the excipient particles and not at particle boundaries, creating new surfaces not previously exposed to Mg stearate. Such uncoated surfaces may well promote adhesive interactions with tools during manufacture.

  • 27.
    Berggren, Carina
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Markinger, Monica
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Spricktillväxt i styv PVC.1989Rapport (Fagfellevurdert)
  • 28.
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Gold-nanoparticle-assisted self-assembly of chemical gradients with tunable sub-50 nm molecular domains2014Inngår i: Particle & particle systems characterization, ISSN 0934-0866, E-ISSN 1521-4117, Vol. 31, nr 2, s. 209-218Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A simple and efficient principle for nanopatterning with wide applicability in the sub-50 nanometer regime is chemisorption of nanoparticles; at homogeneous substrates, particles carrying surface charge may spontaneously self-organize due to the electrostatic repulsion between adjacent particles. Guided by this principle, a method is presented to design, self-assemble, and chemically functionalize gradient nanopatterns where the size of molecular domains can be tuned to match the level corresponding to single protein binding events. To modulate the binding of negatively charged gold nanoparticles both locally (<100 nm) and globally (>100 μm) onto a single modified gold substrate, ion diffusion is used to achieve spatial control of the particles' mutual electrostatic interactions. By subsequent tailoring of different molecules to surface-immobilized particles and the void areas surrounding them, nanopatterns are obtained with variable chemical domains along the gradient surface. Fimbriated Escherichia coli bacteria are bound to gradient nanopatterns with similar molecular composition and macroscopic contact angle, but different sizes of nanoscopic presentation of adhesive (hydrophobic) and repellent poly(ethylene) glycol (PEG) domains. It is shown that small hydrophobic domains, similar in size to the diameter of the bacterial fimbriae, supported firmly attached bacteria resembling catch-bond binding, whereas a high number of loosely adhered bacteria are observed on larger hydrophobic domains. Chemical gradients with the resolution needed to address complex biological binding events at the single protein level are prepared using surface-deposited gold nanoparticles as a versatile template for orthogonal chemicalmodifications. The effect of hydrophobic domain arrangement on the sub-50 nm scale is shown to influence binding of fimbriae carrying E. coli bacteria. 

  • 29.
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Gradients in surface nanotopography used to study platelet adhesion and activation2013Inngår i: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 110, nr 1, s. 261-269Artikkel i tidsskrift (Fagfellevurdert)
  • 30.
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Pellet formation of zygomycetes and immobilization of yeast2013Inngår i: New Biotechnology, ISSN 1871-6784, E-ISSN 1876-4347, Vol. 30, nr 5, s. 516-522Artikkel i tidsskrift (Fagfellevurdert)
  • 31.
    Besharat, Zahra
    et al.
    KTH Royal Institute of Technology, Sweden.
    Wakeham, Deborah
    KTH Royal Institute of Technology, Sweden.
    Johnson, C. Magnus
    KTH Royal Institute of Technology, Sweden.
    Luengo, Gustavo S.
    L’Oréal Research and Innovation, France.
    Greaves, Andrew
    L’Oréal Research and Innovation, France.
    Odnevall Wallinder, Inger
    KTH Royal Institute of Technology, Sweden.
    Göthelid, Mats
    KTH Royal Institute of Technology, Sweden.
    Rutland, Mark W.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science. KTH Royal Institute of Technology, Sweden.
    Mixed monolayers of alkane thiols with polar terminal group on gold: Investigation of structure dependent surface properties2016Inngår i: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 484, s. 279-290Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Adsorption of thiols with cationic or anionic terminal group on gold has been studied from mixed solutions of 11-Amino-1-undecanethiol (AUT) and 3-Mercaptopropionic acid (MPA) using Quartz Crystal Microbalance with Dissipation (QCM-D), X-ray Photoelectron Spectroscopy (XPS), atomic force microscopy (AFM) and contact angles. The goal is to probe the nature of such layers, and the additivity or otherwise of the pH responsiveness, with a view to evaluate their suitability as smart materials. For each of the two pure (unmixed) cases, ordered molecular monolayers are formed with sulfur binding to gold and the alkane chain pointing out from the surface as expected. Adsorption from the thiol mixtures, however, leads to a more complex behaviour. The surface concentration of thiols from the mixtures, as determined by QCM-D, is considerably lower than for the pure cases and it reaches a minimum at a 3:1 MPA/AUT relative concentration in the solution. The XPS results confirm a reduction in adsorbed amount in mixtures with the lowest overall intensity for the 3:1 ratio. Monolayers formed from mixtures display a wettability which is much lower and less pH sensitive. Collectively these results confirm that for adsorption from mixed systems, the configuration is completely different. Complex formation in the mixed solutions leads to the adsorption of molecules parallel to the surface in an axially in-plane configuration. This parallel layer of thiols is mechanically relatively robust to nano-shaving based on AFM measurements. These results will have a significant impact on the design of biomimetic surface coatings particularly when mixtures of oppositely charged molecules are present on the surface, as is commonly the case in biological, proteinaceous surfaces (e.g. hair and skin).

  • 32.
    Bhattacharya, Kunal
    et al.
    Karolinska Institute, Sweden.
    El-Sayed, Ramy
    Karolinska Institute, Sweden.
    Andón, Fernando T.
    Karolinska Institute, Sweden.
    Mukherjee, Sourav P
    Karolinska Institute, Sweden.
    Gregory, Joshua
    Karolinska Institute, Sweden.
    Li, Hu
    Uppsala University, Sweden.
    Zhao, Yichen
    KTH Royal Institute of Technology, Sweden.
    Seo, Wanji
    University of Pittsburgh, US.
    Fornara, Andrea
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Brandner, Birgit
    RISE., SP – Sveriges Tekniska Forskningsinstitut.
    Toprak, Muhammet S.
    KTH Royal Institute of Technology, Sweden.
    Leifer, Klaus
    Uppsala University, Sweden.
    Star, Alexander
    University of Pittsburgh, US.
    Fadeel, Bengt
    Karolinska Institute, Sweden.
    Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant2015Inngår i: Carbon, ISSN 0008-6223, E-ISSN 1873-3891, Vol. 91, s. 506-517Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Carbon nanotubes (CNTs) may elicit inflammatory responses following pulmonary exposure. Conversely, enzymatic biodegradation of CNTs by inflammatory cells has also been reported. The aim of this study was to study the degradation of oxidized single-walled CNTs (ox-SWCNTs) by lactoperoxidase (LPO), a secreted peroxidase present in the airways, and whether pulmonary surfactant affects this biodegradation. To this end, ox-SWCNTs were incubated in vitro with recombinant bovine LPO + H2O2 + NaSCN in the presence and absence of porcine lung surfactant (Curosurf®) and biodegradation was monitored using UV-Vis-NIR spectroscopy, Raman spectroscopy, and scanning electron microscopy. The interaction of recombinant LPO with bundles of ox-SWCNTs was confirmed by atomic force microscopy. Cell-free biodegradation of ox-SWCNTs was also observed ex vivo in murine bronchoalveolar lavage fluid in the presence of H2O2 + NaSCN. Our study provides evidence for biodegradation of ox-SWCNTs with a lung surfactant 'bio-corona' and expands the repertoire of mammalian peroxidases capable of biodegradation of ox-SWCNTs. These findings are relevant to inhalation exposure to these materials, as LPO serves as an important component of the airway defense system.

  • 33.
    Björkegren, Helena
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Bylander, Marianne
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Löwendahl, Reidun
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Interlaboratory testing of seam slippage1990Rapport (Fagfellevurdert)
  • 34.
    Björkegren, Helena
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Bylander, Marianne
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Löwendahl, Reidun
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Sömskridning1990Rapport (Fagfellevurdert)
  • 35.
    Björn, Camilla
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. University of Gothenburg, Sweden; Sahlgrenska Academy, Sweden.
    Antimicrobial peptides in the treatment of infectious and inflammatory conditions: Preclinical studies of mechanism of action, efficacy, and safety2016Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious diseases. AMPs are present in all living species and constitute an important part of the innate immune system in multicellular organisms, including humans. AMPs display a remarkably broad spectrum of antimicrobial activity covering both Gram-positive and Gram-negative bacteria, including many antibiotic-resistant strains, as well as fungi, viruses, and protozoa. Further, in contrast to many conventional antibiotics, AMPs rapidly kill bacteria instead of just inhibiting bacterial growth. In addition, AMPs act as modulators of the innate immune system and, importantly, bacteria seem less efficient in developing resistance towards AMPs than towards conventional antibiotics. Together these properties make AMPs highly attractive as a new class of antimicrobials, with clinical potential also extending to diseases where inflammation is part of the pathology. The aim of this thesis was to study novel AMPs with respect to their mechanism of action (MOA), antimicrobial spectrum, propensity to select for resistance, and in vivo efficacy and safety. To achieve this, we used a number of in vitro and in vivo assays, together generating a comprehensive preclinical evaluation of the peptides. The hypothesis was that the AMPs in this thesis have potential to be developed as therapeutic agents for several infectious and inflammatory conditions, including treatment of skin and soft tissue infections and prevention of postsurgical adhesion formation. The results showed that all AMPs tested (i.e. PXL03, PXL150, HLR1r, and five variants of CEN1 HC-Br) had broad antimicrobial spectra in vitro with varying sensitivity to salt and serum. Furthermore, PXL150 caused a rapid permeabilization of bacterial membrane in vitro, indicating that this is at least one part of the MOA of this peptide. Under selection pressure in vitro, bacteria did not develop resistance to the peptides tested, i.e. PXL150 and CEN1 HC. Interestingly, all peptides showed anti-inflammatory activity by inhibiting the secretion of proinflammatory mediators from stimulated human cell lines. In addition, PXL01, PXL150, and HLR1r demonstrated fibrinolytic ability in vitro by suppressing the release of plasminogen activator inhibitor-1 (PAI-1). In ex vivo and in vivo skin/wound infection models, the peptides reduced the number of viable bacteria and yeast cells. Further, PXL01 decreased postsurgical adhesion formation in vivo. Notably, nonclinical safety studies showed that PXL150 was safe and well tolerated. In conclusion, several of the peptides evaluated in this thesis demonstrated a promising preclinical efficacy and safety profile motivating further development as drug candidates for local treatment of infectious and inflammatory conditions.

  • 36.
    Björn, Camilla
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. Pergamum AB, Sweden; University of Gothenburg, Sweden.
    Mahlapuu, Margit
    Pergamum AB, Sweden; University of Gothenburg, Sweden.
    Mattsby-Baltzer, Inger
    University of Gothenburg, Sweden.
    Håkansson, Joakim
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. Pergamum AB, Sweden.
    Anti-infective efficacy of the lactoferrin-derived antimicrobial peptide HLR1r2016Inngår i: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 81, s. 21-28Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Antimicrobial peptides (AMPs) have emerged as a new class of drug candidates for the treatment of infectious diseases. Here we describe a novel AMP, HLR1r, which is structurally derived from the human milk protein lactoferrin and demonstrates a broad spectrum microbicidal action in vitro. The minimum concentration of HLR1r needed for killing ≥99% of microorganisms in vitro, was in the range of 3-50 μg/ml for common Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and for the yeast Candida albicans, when assessed in diluted brain-heart infusion medium. We found that HLR1r also possesses anti-inflammatory properties as evidenced by inhibition of tumor necrosis factor alpha (TNF-α) secretion from human monocyte-derived macrophages and by repression of interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1) secretion from human mesothelial cells, without any cytotoxic effect observed at the concentration range tested (up to 400 μg/ml). HLR1r demonstrated pronounced anti-infectious effect in in vivo experimental models of cutaneous candidiasis in mice and of excision wounds infected with MRSA in rats as well as in an ex vivo model of pig skin infected with S. aureus. In conclusion, HLR1r may constitute a new therapeutic alternative for local treatment of skin infections.

  • 37.
    Björn, Camilla
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. Pergamum AB, Sweden; University of Gothenburg, Sweden.
    Noppa, Lalia
    FOI Swedish Defence Research Agency, Sweden.
    Näslund Salomonsson, Emelie
    FOI Swedish Defence Research Agency, Sweden.
    Johansson, Anna-Lena
    FOI Swedish Defence Research Agency, Sweden.
    Nilsson, Elin
    FOI Swedish Defence Research Agency, Sweden.
    Mahlapuu, Margit
    Pergamum AB, Sweden; University of Gothenburg, Sweden.
    Håkansson, Joakim
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. Pergamum AB, Sweden.
    Efficacy and safety profile of the novel antimicrobial peptide PXL150 in a mouse model of infected burn wounds2015Inngår i: International Journal of Antimicrobial Agents, ISSN 0924-8579, E-ISSN 1872-7913, Vol. 45, nr 5, s. 519-524Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The urgent need to develop novel antimicrobial therapies has stimulated interest in antimicrobial peptides as therapeutic candidates for the treatment of infectious diseases. The aim of this study was to evaluate the anti-infectious effect of the synthetic antimicrobial peptide PXL150, formulated in hydroxypropyl cellulose (HPC) gel, on Pseudomonas aeruginosa in vitro and in an in vivo mouse model of infected burn wounds as well as to assess the in vivo safety profile of PXL150 in rats and rabbits. Minimal microbicidal concentration analysis showed prominent efficacy of PXL150 against P. aeruginosa in vitro, which was further enhanced in formulating the peptide in HPC gel. Application of 1.25, 2.5, 5, 10 and 20 mg/g PXL150 in HPC gel twice daily for four consecutive days significantly reduced bacterial counts in the burn wounds compared with non-treated or placebo-treated controls. Continuous bioluminescence measurements of the bacteria revealed a pronounced anti-infective effect already at the first day post infection by PXL150 in concentrations of ≥2.5 mg/g. In the non-clinical safety studies, PXL150 showed a favourable safety profile following repeated administration systemically and locally in rats and rabbits, respectively. In conclusion, these data support that PXL150 has the potential to be an effective and safe drug candidate for the treatment of infected burn wounds. The findings encourage the progression of PXL150 as a novel topical treatment of microbial infections.

  • 38.
    Blomberg, Eva
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Adsorption of lysozyme on silver and its influence on silver release2014Inngår i: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 30, nr 46, s. 13877-13889Artikkel i tidsskrift (Fagfellevurdert)
  • 39.
    Blomberg, Eva
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Chemical, mechanical and antibacterial properties of silver nanocluster/silica composite coated textiles for safety systems and aerospace applications2014Inngår i: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 317, nr Oct, s. 131-139Artikkel i tidsskrift (Fagfellevurdert)
  • 40.
    Blomberg, Eva
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Correlation between surface physicochemical properties and the release of iron from stainless steel AISI 304 in biological media2014Inngår i: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 122, nr Oct, s. 216-222Artikkel i tidsskrift (Fagfellevurdert)
  • 41.
    Blomberg, Eva
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Effect of laundry surfactants on surface charge and colloidal stability of silver nanoparticles2013Inngår i: Langmuir, Vol. 29, nr 28, s. 8882-8891Artikkel i tidsskrift (Fagfellevurdert)
  • 42.
    Blomqvist, P
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Månsson, M
    Fire characteristics and detailed smoke gas analyses in controlled underventilated large-scale combustion experiments.1996Inngår i: Industrial fires III, Workshop Proceedings, European commission, Risø, Denmark, 17-18 september 1996., European Commission , 1996, , s. 7-16Konferansepaper (Annet vitenskapelig)
  • 43.
    Blomqvist, Per
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP Sveriges tekniska forskningsinstitut / Brandteknik, forskning (BRf ).
    Lindberg, Per
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Certifiering, Ledningssystemcertifiering.
    Månsson, Margret
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    TOXFIRE - Fire characteristics and smoke gas analyses in under-ventilated large-scale combustion experments. FTIR measurements.1996Rapport (Fagfellevurdert)
  • 44.
    Bobert, Magnus
    et al.
    Brandteknik, skydd (BRs ).
    Buren, Anneli
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Spilg, Leo
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Andersson, Petra
    Brandteknik, forskning (BRf ).
    Framtagning av underlag till komponentprovning av linjevärmedetektorer för fasadmontering2007Rapport (Fagfellevurdert)
    Abstract [sv]

    Suggestions for how to test and verify line type heat detectors suitable for facade mounting are given. Related standards including prEN54:22 are discussed. Key words: Linjevärmedetektorer, komponentprovningar, beständighetstest, funktionstest

  • 45.
    Boge, Lukas
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science. Chalmers University of Technology, Sweden.
    Bysell, Helena
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Ringstad, Lovisa
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Wennman, David
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Process Development, Analys och fastfas.
    Umerska, Anita
    University of Angers, France.
    Cassisa, Viviane
    CHU Angers, France.
    Eriksson, Jonny
    Uppsala University, Sweden.
    Joly-Guillou, Marie-Laure
    CHU Angers, France.
    Edwards, Katarina
    Uppsala University, Sweden.
    Andersson, Martin
    Chalmers University of Technology, Sweden.
    Lipid-based liquid crystals as carriers for antimicrobial peptides: Phase behavior and antimicrobial effect2016Inngår i: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 32, nr 17, s. 4217-4228Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The number of antibiotic-resistant bacteria is increasing worldwide, and the demand for novel antimicrobials is constantly growing. Antimicrobial peptides (AMPs) could be an important part of future treatment strategies of various bacterial infection diseases. However, AMPs have relatively low stability, because of proteolytic and chemical degradation. As a consequence, carrier systems protecting the AMPs are greatly needed, to achieve efficient treatments. In addition, the carrier system also must administrate the peptide in a controlled manner to match the therapeutic dose window. In this work, lyotropic liquid crystalline (LC) structures consisting of cubic glycerol monooleate/water and hexagonal glycerol monooleate/oleic acid/water have been examined as carriers for AMPs. These LC structures have the capability of solubilizing both hydrophilic and hydrophobic substances, as well as being biocompatible and biodegradable. Both bulk gels and discrete dispersed structures (i.e., cubosomes and hexosomes) have been studied. Three AMPs have been investigated with respect to phase stability of the LC structures and antimicrobial effect: AP114, DPK-060, and LL-37. Characterization of the LC structures was performed using small-angle X-ray scattering (SAXS), dynamic light scattering, ζ-potential, and cryogenic transmission electron microscopy (Cryo-TEM) and peptide loading efficacy by ultra performance liquid chromatography. The antimicrobial effect of the LCNPs was investigated in vitro using minimum inhibitory concentration (MIC) and time-kill assay. The most hydrophobic peptide (AP114) was shown to induce an increase in negative curvature of the cubic LC system. The most polar peptide (DPK-060) induced a decrease in negative curvature while LL-37 did not change the LC phase at all. The hexagonal LC phase was not affected by any of the AMPs. Moreover, cubosomes loaded with peptides AP114 and DPK-060 showed preserved antimicrobial activity, whereas particles loaded with peptide LL-37 displayed a loss in its broad-spectrum bactericidal properties. AMP-loaded hexosomes showed a reduction in antimicrobial activity.

  • 46.
    Bogren, Maria
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Linde, Maria
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Inverkan av upprepad bearbetning med mellanliggande accelererad åldring på en ostabiliserad LDPE.1993Rapport (Fagfellevurdert)
  • 47.
    Boldizar, Antal
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Miljödriven företagsutveckling. En enkätundersöknng om behov av miljörelaterade tjänster bland företag i Sjuhäradsbygden1997Rapport (Fagfellevurdert)
  • 48.
    Boldizar, Antal
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Jansson, Anna
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Upprepad återvinning av mineralfylld PP1997Rapport (Fagfellevurdert)
  • 49.
    Boldizar, Antal
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Markinger, Monica
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Henriksson, Lars-Åke
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Metoder för verifiering av utrustningskriterier för innebandy. *SP-Metod 1506*.1993Rapport (Fagfellevurdert)
  • 50. Boldizar, Antal
    et al.
    Möller, Kenneth
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Degradation of ABS during repeated processing and accelerated ageing2003Inngår i: Polymer Degradation Stab., Vol. 81, s. 359-366Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Degradation of ABS during repeated processing and accelerated ageing

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