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  • 1.
    Altmann, Brigitte
    et al.
    University Medical Center Freiburg, Germany.
    Rabel, Kerstin
    University Medical Center Freiburg, Germany.
    Kohal, Ralf J.
    University Medical Center Freiburg, Germany.
    Proksch, Susanne
    University Medical Center Freiburg, Germany.
    Tomakidi, Pascal
    University Medical Center Freiburg, Germany.
    Adolfsson, Erik
    RISE - Research Institutes of Sweden, Material och produktion, IVF.
    Bernsmann, Falk
    NTTF Coatings GmbH, Germany.
    Palmero, Paola
    Politecnico di Torino, Italy.
    Fürderer, Tobias
    MOESCHTER GROUP Holding GmbH, Germany.
    Steinberg, Thorsten
    University Medical Center Freiburg, Germany.
    Cellular transcriptional response to zirconia-based implant materials2017Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 33, nr 2, s. 241-255Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective To adequately address clinically important issues such as osseointegration and soft tissue integration, we screened for the direct biological cell response by culturing human osteoblasts and gingival fibroblasts on novel zirconia-based dental implant biomaterials and subjecting them to transcriptional analysis. Methods Biomaterials used for osteoblasts involved micro-roughened surfaces made of a new type of ceria-stabilized zirconia composite with two different topographies, zirconium dioxide, and yttria-stabilized zirconia (control). For fibroblasts smooth ceria- and yttria-stabilized zirconia surface were used. The expression of 90 issue-relevant genes was determined on mRNA transcription level by real-time PCR Array technology after growth periods of 1 and 7 days. Results Generally, modulation of gene transcription exhibited a dual dependence, first by time and second by the biomaterial, whereas biomaterial-triggered changes were predominantly caused by the biomaterials’ chemistry rather than surface topography. Per se, modulated genes assigned to regenerative tissue processes such as fracture healing and wound healing and in detail included colony stimulating factors (CSF2 and CSF3), growth factors, which regulate bone matrix properties (e.g. BMP3 and TGFB1), osteogenic BMPs (BMP2/4/6/7) and transcription factors (RUNX2 and SP7), matrix collagens and osteocalcin, laminins as well as integrin ß1 and MMP-2. Significance With respect to the biomaterials under study, the screening showed that a new zirconia-based composite stabilized with ceria may be promising to provide clinically desired periodontal tissue integration. Moreover, by detecting biomarkers modulated in a time- and/or biomaterial-dependent manner, we identified candidate genes for the targeted analysis of cell-implant bioresponse during biomaterial research and development.

  • 2.
    Ballo, Ahmed Mansour
    et al.
    University of British Columbia, Canada; College of Dentistry at King Saud University, Saudi Arabia.
    Cekic-Nagas, Isil
    Gazi University, Turkey.
    Ergün, Gülfem
    Gazi University, Turkey.
    Lassila, Lippo Veli Juhana
    University of Turku, Finland.
    Palmquist, Anders
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Borchardt, Per
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Organisk kemi (Kmo). BIOMATCELL, Sweden.
    Lausmaa, Jukka
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf). BIOMATCELL, Sweden.
    Thomsen, Peter
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Vallittu, Pekka Kalevi
    University of Turku, Finland.
    Närhi, Timo O.
    University of Turku, Finland; Turku University Central Hospital, Finland.
    Osseointegration of fiber-reinforced composite implants: Histological and ultrastructural observations2014Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 30, nr 12, s. e384-e395Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives. The aim of this study was to evaluate the bone tissue response to fiber-reinforced composite (FRC) in comparison with titanium (Ti) implants after 12 weeks of implantation in cancellous bone using histomorphometric and ultrastructural analysis. Materials and methods. Thirty grit-blasted cylindrical FRC implants with BisGMA-TEGDMA polymer matrix were fabricated and divided into three groups: (1) 60 s light-cured FRC (FRC-L group), (2) 24 h polymerized FRC (FRC group), and (3) bioactive glass FRC (FRC-BAG group). Titanium implants were used as a control group. The surface analyses were performed with scanning electron microscopy and 3D SEM. The bone-implant contact (BIC) and bone area (BA) were determined using histomorphometry and SEM. Transmission electron microscopy (TEM) was performed on Focused Ion Beam prepared samples of the intact bone-implant interface. Results. The FRC, FRC-BAG and Ti implants were integrated into host bone. In contrast, FRC-L implants had a consistent fibrous capsule around the circumference of the entire implant separating the implant from direct bone contact. The highest values of BIC were obtained with FRC-BAG (58 ± 11%) and Ti implants (54 ± 13%), followed by FRC implants (48 ± 10%), but no significant differences in BIC or BA were observed (p = 0.07, p = 0.06, respectively). TEM images showed a direct contact between nanocrystalline hydroxyapatite of bone andboth FRC and FRC-BAG surfaces. Conclusion. Fiber-reinforced composite implants are capable of establishing a close bone contact comparable with the osseointegration of titanium implants having similar surface roughness.

  • 3.
    Spies, Benedikt C
    et al.
    University of Freiburg, Germany; Humboldt-Universität zu Berlin, Germany.
    Fross, Alexander
    University of Freiburg, Germany.
    Adolfsson, Erik
    RISE - Research Institutes of Sweden, Material och produktion, IVF.
    Bagegni, Aimen
    University of Freiburg, Germany.
    Doerken, Sam
    University of Freiburg, Germany.
    Kohal, Ralf-Joachim
    University of Freiburg, Germany.
    Stability and aging resistance of a zirconia oral implant using a carbon fiber-reinforced screw for implant-abutment connection2018Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 34, nr 10, s. 1585-1595Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: To investigate the long-term stability of a metal-free zirconia two-piece implant assembled with a carbon fiber-reinforced (CRF) screw by means of transformation propagation, potential changes in surface roughness, the gap size of the implant-abutment connection, and fracture load values.

    METHODS: In a combined procedure, two-piece implants made from alumina-toughened zirconia were dynamically loaded (107 cycles) and hydrothermally aged (85°, 60days). Implants made from titanium (Ti) and a titanium-zirconium (TiZr) alloy with a titanium abutment screw served as control. Transformation propagation (ATZ) and gap size of the IAC were monitored at cross-sections by scanning electron microscopy (SEM). Furthermore, changes in surface roughness of ATZ implants were measured. Finally, implants were statically loaded to fracture. Linear regression models and pairwise comparisons were used for statistical analyses.

    RESULTS: Independent of the implant bulk material, dynamic loading/hydrothermal aging did not decrease fracture resistance (p=0.704). All test and control implants fractured at mean loads >1100N. Gap size of the IAC remained stable (<5μm) or decreased. None of the CFR screws fractured during static or dynamic loading. Monoclinic layer thickness of ATZ implants increased by 2-3μm at surfaces exposed to water, including internal surfaces of the IAC. No changes in surface roughness were observed.

    SIGNIFICANCE: Combined hydrothermal aging and dynamic loading did not affect the above-mentioned parameters of the evaluated two-piece ATZ implant. Mean fracture loads >1100N suggest a reliable clinical application.

  • 4.
    Viljanen, E.K.
    et al.
    University of Turku.
    Lassila, L.V.J.
    University of Turku.
    Skrifvars, Mikael
    RISE, Swerea, Swerea SICOMP AB.
    Vallittu, P.K.
    University of Turku.
    Degree of conversion and flexural properties of a dendrimer/methyl methacrylate copolymer: Design of experiments and statistical screening2005Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 21, nr 2, s. 172-177Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: The aim of this study was to investigate the effect of photosensitive initiator and activator concentrations on the degree of conversion and flexural properties of an experimental photopolymerized dental copolymer containing dendrimer. Methods: The experimental resin system consisted of a dendrimer with 12 methacrylate groups and methyl methacrylate in a mass ratio of 80:20. The initiator and activator used were camphorquinone and 2-(N,N-dimethylamino)ethyl methacrylate, whose concentrations varied individually from 1 to 4wt%. The degree of conversion was determined with FTIR spectroscopy, and flexural strength and flexural modulus with the three-point bending test. The experiments were designed and analyzed, and the results plotted with Modde 5.0 software. Results: The highest degree of conversion was obtained with 2.5wt% initiator and activator concentrations, the highest flexural strength with 2.5wt% initiator and 1.0wt% activator concentration, and the highest flexural modulus with 1.0wt% initiator and activator concentrations. Significance: The results indicated that the degree of conversion increased, and flexural strength and flexural modulus decreased, with increasing initiator and activator concentrations. The high concentrations of initiator probably inhibited the transmittance of the active wavelengths to the depths of the samples (the inner filter effect), resulting in inhomogeneous conversion and thus decreased mechanical properties. © 2004 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

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