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  • 1.
    Anderud, Jonas
    et al.
    Malmö University, Sweden; Region Halland, Sweden.
    Jimbo, Ryo
    Malmö University, Sweden.
    Abrahamsson, Peter
    Region Halland, Sweden.
    Adolfsson, Erik
    RISE - Research Institutes of Sweden, Materials and Production, IVF.
    Malmström, Johan
    Region Halland, Sweden.
    Wennerberg, Ann
    Malmö University, Sweden.
    The impact of surface roughness and permeability in hydroxyapatite bone regeneration membranes2015In: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 27, no 8, p. 1047-1054Article in journal (Refereed)
    Abstract [en]

    Background: One of the crucial aspects in guided bone regeneration is the space maintenance. This is normally created by a membrane, which should primarily be accepted by the surrounding tissues without causing any adverse reactions. The impact of surface topography, biological acceptance as well as permeability of these membranes has been carefully discussed in the literature. Purpose: The purpose of this study was to evaluate histologically the bone forming properties inside of hollow hydroxyapatite space-maintaining devices with different inner surfaces and different permeabilities in an animal calvaria model in vivo. Materials and methods: A total of 36 hollow domes with three different designs made of hydroxyapatite were surgically attached to the skulls of rabbits. Group 1 had a moderately rough inner surface. Group 2 had a smooth inner surface. Group 3 had the same properties as Group 1 but had macroscopic holes on the top. The domes were left to heal for 12 weeks and were then processed for undecalcified ground sectioning. Histological evaluations were performed using a light microscope and scanning electron microscopy. The bone-implant contact (BIC) percentage along the device was calculated. Results: The median percentage of BIC was higher for Group 1 compared with Group 2 (P = 0.004). Group 1 produced a larger median BIC compared with Group 3 (P < 0.0001). Conclusions: Within the limits of this preclinical study, these findings suggest that a moderately rough inner surface of a ceramic membrane along with a non-permeable device produces more bone than a smooth inner surface.

  • 2.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Bone response to physical-vapour-deposited titanium dioxide coatings on titanium implants2013In: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 24, no 9, p. 1009-1017Article in journal (Refereed)
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