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  • 1.
    Flys, Olena
    et al.
    RISE - Research Institutes of Sweden (2017-2019), Säkerhet och transport, Mätteknik. Halmstad University, Sweden.
    Jarlemark, Per
    RISE - Research Institutes of Sweden (2017-2019), Säkerhet och transport, Mätteknik.
    Petronis, Sarunas
    RISE - Research Institutes of Sweden (2017-2019), Biovetenskap och material, Kemi och material.
    Stenlund, Patrik
    RISE - Research Institutes of Sweden (2017-2019), Biovetenskap och material, Kemi och material.
    Rosen, B. -G
    Halmstad University, Sweden.
    Applicability of characterization techniques on fine scale surfaces2018Inngår i: Surface Topography: Metrology and Properties, ISSN 2051-672X, Vol. 6, nr 3, artikkel-id 034015Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this study, several surface topographies typical for dental implants were evaluated by different measurement techniques. The samples were prepared by machine turning, wet chemical etching and electrochemical polishing of titanium discs. The measurement techniques included an atomic force microscope (AFM), coherence scanning interferometer (CSI) and a 3D stereo scanning electron microscope (SEM). The aim was to demonstrate and discuss similarities and differences in the results provided by these techniques when analyzing submicron surface topographies. The estimated surface roughness parameters were not directly comparable since the techniques had different surface spatial wavelength band limits. However, the comparison was made possible by applying a 2D power spectral density (PSD) function. Furthermore, to simplify the comparison, all measurements were characterized using the ISO 25178 standard parameters. Additionally, a Fourier transform was applied to calculate the instrument transfer function in order to investigate the behavior of CSI at different wavelength ranges. The study showed that 3D stereo SEM results agreed well with AFM measurements for the studied surfaces. Analyzed surface parameter values were in general higher when measured by CSI in comparison to both AFM and 3D stereo SEM results. In addition, the PSD analysis showed a higher power spectrum density in the lower frequency range 10-2-10-1 μm-1 for the CSI compared with the other techniques.

  • 2.
    Gilljam, Karin M
    et al.
    Regenics AS, Norway.
    Stenlund, Patrik
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Standoft, Simon
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Andersen, Sisse Bindslev
    Scantox A/S, Denmark.
    Kaaber, Kari
    Scantox A/S, Denmark.
    Lund, Henrik
    Regenics AS, Norway.
    Bryn, Karl R K
    Regenics AS, Norway.
    Alginate and nanocellulose dressings with extract from salmon roe reduce inflammation and accelerate healing of porcine burn wounds.2023Inngår i: Journal of Burn Care & Research, ISSN 1559-047X, E-ISSN 1559-0488, Vol. 44, nr 5, s. 1140-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Partial thickness thermal burn wounds are characterized by prolonged inflammatory response, oxidative stress, tissue damage, and secondary necrosis. An optimal dressing for burn wounds would reduce inflammation and oxidative stress while providing a moist, absorbent, and protective cover. We have developed an extract from unfertilized salmon roe containing components with potential anti-inflammatory and antioxidative properties, called HTX. HTX has been combined with alginate from brown algae and nanocellulose from tunicates, and 3D printed into a solid hydrogel wound dressing called Collex. Here, Collex was tested on partial thickness burn wounds in Göttingen minipigs compared to Jelonet, and a variant of Collex without HTX. We found that dermal treatment of burn wounds with Collex resulted in accelerated healing at a majority of measured points over 23 days, compared to treatment with Jelonet. In comparison to Collex without HTX, Collex enhanced healing in the first week after trauma where wound progression was pronounced. Notably, Collex reduced the inflammatory response in the early post-injury phase. The anti-inflammatory response of Collex was investigated in more detail on activated M1 macrophages. We found that Collex, as well as HTX alone, significantly reduced secretion of pro-inflammatory interleukin-1β as well as intracellular levels of oxidative stress. The results from this study indicate that Collex is a potent dressing for treatment of burn wounds, with the anti-inflammatory effect of HTX beneficial in the initial phase, and the moist qualities of the hydrogel favorable both in the initial and the proceeding proliferative phase of wound healing.

  • 3.
    Granskog, Viktor
    et al.
    KTH Royal Institute of Technology, Sweden.
    García-Gallego, Sandra
    KTH Royal Institute of Technology, Sweden.
    von Kieseritzky, Johanna
    Karolinska Institutet, Sweden.
    Rosendahl, Jennifer
    RISE - Research Institutes of Sweden (2017-2019), Biovetenskap och material, Kemi och material.
    Stenlund, Patrik
    RISE - Research Institutes of Sweden (2017-2019), Biovetenskap och material, Kemi och material.
    Zhang, Yuning
    KTH Royal Institute of Technology, Sweden.
    Petronis, Sarunas
    RISE - Research Institutes of Sweden (2017-2019), Biovetenskap och material, Kemi och material.
    Lyvén, Benny
    RISE - Research Institutes of Sweden (2017-2019), Biovetenskap och material, Kemi och material.
    Arner, Marianne
    Karolinska Institutet, Sweden.
    Håkansson, Joakim
    RISE - Research Institutes of Sweden (2017-2019), Biovetenskap och material, Kemi och material.
    Malkoch, Michael
    KTH Royal Institute of Technology, Sweden.
    High-Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair2018Inngår i: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 28, nr 26, artikkel-id 1800372Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The use of adhesives for fracture fixation can revolutionize the surgical procedures toward more personalized bone repairs. However, there are still no commercially available adhesive solutions mainly due to the lack of biocompatibility, poor adhesive strength, or inadequate fixation protocols. Here, a surgically realizable adhesive system capitalizing on visible light thiol–ene coupling chemistry is presented. The adhesives are carefully designed and formulated from a novel class of chemical constituents influenced by dental resin composites and self-etch primers. Validation of the adhesive strength is conducted on wet bone substrates and accomplished via fiber-reinforced adhesive patch (FRAP) methodology. The results unravel, for the first time, on the promise of a thiol–ene adhesive with an unprecedented shear bond strength of 9.0 MPa and that surpasses, by 55%, the commercially available acrylate dental adhesive system Clearfil SE Bond of 5.8 MPa. Preclinical validation of FRAPs on rat femur fracture models details good adhesion to the bone throughout the healing process, and are found biocompatible not giving rise to any inflammatory response. Remarkably, the FRAPs are found to withstand loads up to 70 N for 1000 cycles on porcine metacarpal fractures outperforming clinically used K-wires and match metal plates and screw implants.

    Fulltekst (pdf)
    fulltext
  • 4.
    Harmankaya, Necati
    et al.
    University of Gothenburg, Sweden.
    Igawa, Kazuyo
    University of Tokyo, Japan.
    Stenlund, Patrik
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Palmquist, Anders
    University of Gothenburg, Sweden.
    Tengvall, Pentti
    University of Gothenburg, Sweden.
    Healing of complement activating Ti implants compared with non-activating Ti in rat tibia2012Inngår i: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 8, nr 9, s. 3532-3540Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recent studies have revealed that ozone ultraviolet (UVO) illumination of titanium (Ti) implants improves bone-implant anchorage by altering the physico-chemical and immune activating properties of the titanium dioxide (TiO2) layer. In the present rat tibia model, the authors compared the early events of inflammation and bone formation around UVO-treated Ti and complement activating immunoglobin g (IgG)-coated Ti. Machined Ti and machined Ti coated with a physical vapour-deposited Ti layer were used as references. Screw-shaped test and reference implants were implanted into rat tibia and harvested after 1, 7 and 28 days. Messenger RNA expression of implant adhered cells and peri-implant tissue ∼250 μm from the surface were subsequently analysed with regard to IL-1β, TNF-α, osteocalcin, cathepsin K, BMP-2 and PDGF. Separate implants were retrieved after 7 and 28 days for removal torque measurements, and histological staining and histomorphometric analysis of bone area and bone-to-implant contact. While enhanced expression of inflammatory markers, TNF-α and IL-1β, was observed on IgG-coated surfaces throughout the observation time, UVO-treated surfaces indicated a significantly lower early inflammatory response. In the early phases (1 and 7 days), the UVO-treated surfaces displayed a significantly higher expression of osteoblast markers BMP-2 and osteocalcin. In summary, complement activating Ti implants elicited a stronger inflammatory response than UVO-treated Ti, with low complement activation during the first week of healing. In spite of this, the UVO-treated Ti induced only marginally more bone growth outside the implants.

  • 5.
    Jenndahl, L.
    et al.
    VERIGRAFT AB, Sweden.
    Österberg, K.
    Sahlgrenska Academy, Sweden.
    Bogestål, Yalda
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Simsa, R.
    VERIGRAFT AB, Sweden; University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden.
    Gustafsson-Hedberg, T.
    VERIGRAFT AB, Sweden.
    Stenlund, Patrik
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Petronis, Sarunas
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Krona, Annika
    RISE Research Institutes of Sweden, Bioekonomi och hälsa, Jordbruk och livsmedel.
    Fogelstrand, P.
    University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden.
    Strehl, R.
    VERIGRAFT AB, Sweden.
    Håkansson, Joakim
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning. University of Gothenburg, Sweden.
    Personalized tissue-engineered arteries as vascular graft transplants: A safety study in sheep2022Inngår i: Regenerative Therapy, ISSN 2352-3204, Vol. 21, s. 331-341Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Patients with cardiovascular disease often need replacement or bypass of a diseased blood vessel. With disadvantages of both autologous blood vessels and synthetic grafts, tissue engineering is emerging as a promising alternative of advanced therapy medicinal products for individualized blood vessels. By reconditioning of a decellularized blood vessel with the recipient's own peripheral blood, we have been able to prevent rejection without using immunosuppressants and prime grafts for efficient recellularization in vivo. Recently, decellularized veins reconditioned with autologous peripheral blood were shown to be safe and functional in a porcine in vivo study as a potential alternative for vein grafting. In this study, personalized tissue engineered arteries (P-TEA) were developed using the same methodology and evaluated for safety in a sheep in vivo model of carotid artery transplantation. Five personalized arteries were transplanted to carotid arteries and analyzed for safety and patency as well as with histology after four months in vivo. All grafts were fully patent without any occlusion or stenosis. The tissue was well cellularized with a continuous endothelial cell layer covering the luminal surface, revascularized adventitia with capillaries and no sign of rejection or infection. In summary, the results indicate that P-TEA is safe to use and has potential as clinical grafts. 

  • 6.
    Kieseritzky, Johanna
    et al.
    Karolinska Institutet, Sweden.
    Alfort, Henrik
    Karolinska Institutet, Sweden.
    Granskog, Viktor
    KTH Royal Institute of Technology, Sweden; Biomedical Bonding AB, Sweden.
    Hutchinson, Daniel
    KTH Royal Institute of Technology, Sweden.
    Stenlund, Patrik
    RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
    Bogestål, Yalda
    RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
    Arner, Marianne
    Karolinska Institutet, Sweden.
    Håkansson, Joakim
    Gothenburg University, Sweden.
    Malkoch, Michael
    KTH Royal Institute of Technology, Sweden; Biomedical Bonding AB, Sweden.
    DendroPrime as an adhesion barrier on fracture fixation plates: an experimental study in rabbits2020Inngår i: Journal of Hand Surgery, European Volume, ISSN 1753-1934, E-ISSN 2043-6289, Vol. 45, nr 7, s. 742-747Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We tested the anti-adhesional effect of a new thiol-ene-based coating in a rabbit model. In 12 New Zealand white rabbits, the periosteum and cortex of the proximal phalanx of the second toe of both hind paws was scratched. Stainless steel plates were fixated with screws. One plate was coated with DendroPrime and the other left bare. The non-operated second toes of both hind paws of an additional four rabbits served as controls. Seven weeks after surgery, the soft tissue adhesion to the plates was evaluated macroscopically, and joint mobility was measured biomechanically. Toe joint mobility was about 20% greater and statistically significant in specimens with coated plates compared with the bare plates. Soft tissue overgrowth and, in some cases, synovitis or adhesions between the plate and the tendon were observed on all bare plates but not on any of the coated plates. We conclude that the thiol-ene-based coating can improve joint mobility by about 20%. This material has a potential to reduce adhesion around plates in fracture surgery. © The Author(s) 2020.

    Fulltekst (pdf)
    fulltext
  • 7.
    Kjellin, Per
    et al.
    Promimic AB, Sweden.
    Danielsson, Karin
    Promimic AB, Sweden.
    Håkansson, Joakim
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning. University of Gothenburg, Sweden.
    Agrenius, Karin
    RISE Research Institutes of Sweden, Material och produktion, Kemi och Tillämpad mekanik.
    Andersson, Therese
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Stenlund, Patrik
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Biomechanical and histomorphometric evaluation of skin integration on titanium and PEEK implants with different surface treatments2022Inngår i: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 33, nr 10, artikkel-id 68Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Percutaneous implants are frequently affected by bacterial growth at the skin-implant interface. Integration between implant and surrounding skin is important to prevent bacteria from spreading to the underlying tissue. The standard method to evaluate skin-implant integration is by histomorphometry on samples which have been placed in tissue grown in vivo or ex vivo. In this study, a biomechanical method was developed and evaluated. The integration of implants into porcine skin was studied in an ex vivo model, where pig skin samples were cultivated in a nutrient solution. Cylindrical shaped implants, consisting of polyether ether ketone (PEEK) and titanium (Ti) with different surface treatments, were implanted in the skin tissue and the skin was grown in nutrient solution for 2 weeks. The implants were then extracted from the implantation site and the mechanical force during extraction was measured as a quantitative assessment of skin-implant integration. Implants from each group were also processed for histomorphometry and the degree of epidermal downgrowth (ED) and tissue to implant contact (TIC) was measured. A higher mean pullout force was observed for the PEEK implants compared to the Ti implants. Applying nanosized hydroxyapatite (HA) on Ti and PEEK increased the pullout force compared to uncoated controls, 24% for machined and 70% for blasted Ti, and 51% for machined PEEK. Treatment of Ti and PEEK with nanosized zirconium phosphate (ZrP) did not increase the pullout force. The histomorphometry analysis showed correlation between ED and pullout force, where the pullout force was inversely proportional to ED. For TIC, no significant differences were observed between the groups of same material (i.e. Ti, Ti+HA, Ti+ZrP, and PEEK, PEEK + HA, PEEK + ZrP), but it was significantly higher for PEEK compared to Ti. Scanning electron microscopy analysis was done on samples before and after the pullout tests, showing that the ZrP coating was unaffected by the 2 week ex vivo implantation and pullout procedure, no dissolution or detachment of the coating was observed. For the HA coating, a loss of coating was seen on approximately 5% of the total surface area of the implant. [Figure not available: see fulltext.] © 2022, The Author(s).

  • 8.
    Lausmaa, Jukka
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Stenlund, Patrik
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    A methodological study of the mechanics controlling implant fixation ex vivo2011Inngår i: Annual Conference of the European Society for Biomaterials; EBS 2011, 2011Konferansepaper (Annet vitenskapelig)
  • 9.
    Murase, Kohei
    et al.
    BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Sweden.
    Stenlund, Patrik
    RISE - Research Institutes of Sweden (2017-2019), Biovetenskap och material, Kemi och material. BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Sweden ; University of Gothenburg, Sweden.
    Thomsen, Peter
    BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Sweden.
    Lausmaa, Jukka
    RISE - Research Institutes of Sweden (2017-2019), Biovetenskap och material, Kemi och material. BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Sweden.
    Palmquist, Anders
    BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Sweden ; University of Gothenburg, Sweden.
    Three-dimensional modeling of removal torque and fracture progression around implants.2018Inngår i: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 29, nr 7, artikkel-id 104Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the present study, a model for simulations of removal torque experiments was developed using finite element method. The interfacial retention and fracturing of the surrounding material caused by the surface features during torque was analyzed. It was hypothesized that the progression of removal torque and the phases identified in the torque response plot represents sequential fractures at the interface. The 3-dimensional finite element model fairly accurately predicts the torque required to break the fixation of acid-etched implants, and also provides insight to how sequential fractures progress downwards along the implant side.

    Fulltekst (pdf)
    fulltext
  • 10.
    Rosendahl, Jennifer
    et al.
    RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
    Svanström, Andreas
    University of Gothenburg, Sweden.
    Berglin, Mattias
    RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
    Petronis, Sarunas
    RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
    Bogestål, Yalda
    RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
    Stenlund, Patrik
    RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
    Standoft, Simon
    RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
    Ståhlberg, Anders
    University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden.
    Landberg, Göran
    University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden.
    Chinga-Carrasco, Gary
    RISE Research Institutes of Sweden, Bioekonomi och hälsa, Material- och ytdesign. University of Gothenburg, Sweden.
    Håkansson, Joakim
    University of Gothenburg, Sweden.
    3D Printed Nanocellulose Scaffolds as a Cancer Cell Culture Model System2021Inngår i: Bioengineering, E-ISSN 2306-5354, Vol. 8, nr 7, artikkel-id 97Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Current conventional cancer drug screening models based on two-dimensional (2D) cell culture have several flaws and there is a large need of more in vivo mimicking preclinical drug screening platforms. The microenvironment is crucial for the cells to adapt relevant in vivo characteristics and here we introduce a new cell culture system based on three-dimensional (3D) printed scaffolds using cellulose nanofibrils (CNF) pre-treated with 2,2,6,6-tetramethylpyperidine-1-oxyl (TEMPO) as the structural material component. Breast cancer cell lines, MCF7 and MDA-MB-231, were cultured in 3D TEMPO-CNF scaffolds and were shown by scanning electron microscopy (SEM) and histochemistry to grow in multiple layers as a heterogenous cell population with different morphologies, contrasting 2D cultured mono-layered cells with a morphologically homogenous cell population. Gene expression analysis demonstrated that 3D TEMPO-CNF scaffolds induced elevation of the stemness marker CD44 and the migration markers VIM and SNAI1 in MCF7 cells relative to 2D control. T47D cells confirmed the increased level of the stemness marker CD44 and migration marker VIM which was further supported by increased capacity of holoclone formation for 3D cultured cells. Therefore, TEMPO-CNF was shown to represent a promising material for 3D cell culture model systems for cancer cell applications such as drug screening.

  • 11.
    Shah, Furqan A.
    et al.
    University of Gothenburg, Sweden; BIOMATCELL VINN Excellence Centre of Biomaterials and Cell Therapy, Sweden.
    Stenlund, Patrik
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. University of Gothenburg, Sweden; BIOMATCELL VINN Excellence Centre of Biomaterials and Cell Therapy, Sweden.
    Martinelli, Anna
    Chalmers University of Technology, Sweden.
    Thomsen, Peter
    University of Gothenburg, Sweden; BIOMATCELL VINN Excellence Centre of Biomaterials and Cell Therapy, Sweden.
    Palmquist, Anders
    University of Gothenburg, Sweden; BIOMATCELL VINN Excellence Centre of Biomaterials and Cell Therapy, Sweden.
    Direct communication between osteocytes and acid-etched titanium implants with a sub-micron topography2016Inngår i: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 27, nr 11, artikkel-id 167Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The osteocyte network, through the numerous dendritic processes of osteocytes, is responsible for sensing mechanical loading and orchestrates adaptive bone remodelling by communicating with both the osteoclasts and the osteoblasts. The osteocyte network in the vicinity of implant surfaces provides insight into the bone healing process around metallic implants. Here, we investigate whether osteocytes are able to make an intimate contact with topologically modified, but micrometre smooth (Sa < 0.5 µm) implant surfaces, and if sub-micron topography alters the composition of the interfacial tissue. Screw shaped, commercially pure (cp-Ti) titanium implants with (i) machined (Sa = ~0.2 µm), and (ii) two-step acid-etched (HF/HNO3 and H2SO4/HCl; Sa = ~0.5 µm) surfaces were inserted in Sprague Dawley rat tibia and followed for 28 days. Both surfaces showed similar bone area, while the bone-implant contact was 73 % higher for the acid-etched surface. By resin cast etching, osteocytes were observed to maintain a direct intimate contact with the acid-etched surface. Although well mineralised, the interfacial tissue showed lower Ca/P and apatite-to-collagen ratios at the acid-etched surface, while mineral crystallinity and the carbonate-to-phosphate ratios were comparable for both implant surfaces. The interfacial tissue composition may therefore vary with changes in implant surface topography, independently of the amount of bone formed. Implant surfaces that influence bone to have higher amounts of organic matrix without affecting the crystallinity or the carbonate content of the mineral phase presumably result in a more resilient interfacial tissue, better able to resist crack development during functional loading than densely mineralised bone.

  • 12.
    Stenlund, Patrik
    et al.
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Enstedt, Linnea
    RISE Research Institutes of Sweden, Bioekonomi och hälsa, Kemiska processer och läkemedel.
    Gilljam, Karin
    Regenics AS, Norway.
    Standoft, Simon
    RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
    Ahlinder, Astrid
    RISE Research Institutes of Sweden, Bioekonomi och hälsa, Jordbruk och livsmedel.
    Lundin Johnson, Maria
    RISE Research Institutes of Sweden.
    Lund, Henrik
    Regenics AS, Norway.
    Millqvist-Fureby, Anna
    RISE Research Institutes of Sweden, Bioekonomi och hälsa, Kemiska processer och läkemedel.
    Berglin, Mattias
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning. University of Gothenburg, Sweden.
    Development of an All-Marine 3D Printed Bioactive Hydrogel Dressing for Treatment of Hard-to-Heal Wounds2023Inngår i: Polymers, E-ISSN 2073-4360, Vol. 15, nr 12, artikkel-id 2627Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Current standard wound care involves dressings that provide moisture and protection; however, dressings providing active healing are still scarce and expensive. We aimed to develop an ecologically sustainable 3D printed bioactive hydrogel-based topical wound dressing targeting healing of hard-to-heal wounds, such as chronic or burn wounds, which are low on exudate. To this end, we developed a formulation composed of renewable marine components; purified extract from unfertilized salmon roe (heat-treated X, HTX), alginate from brown seaweed, and nanocellulose from tunicates. HTX is believed to facilitate the wound healing process. The components were successfully formulated into a 3D printable ink that was used to create a hydrogel lattice structure. The 3D printed hydrogel showed a HTX release profile enhancing pro-collagen I alpha 1 production in cell culture with potential of promoting wound closure rates. The dressing has recently been tested on burn wounds in Göttingen minipigs and shows accelerated wound closure and reduced inflammation. This paper describes the dressings development, mechanical properties, bioactivity, and safety. 

  • 13.
    Stenlund, Patrik
    et al.
    RISE - Research Institutes of Sweden, ICT, Acreo.
    Kulbacka-Ortiz, Katarzyna
    Sahlgrenska University Hospital, Sweden.
    Jönsson, Stewe
    Kungsbacka Hospital, Sweden.
    Brånemark, Rickard
    Gothenburg University, Sweden; MIT Massachusetts Institute of Technology, US.
    Loads on Transhumeral Amputees Using Osseointegrated Prostheses2019Inngår i: Annals of Biomedical Engineering, ISSN 0090-6964, E-ISSN 1573-9686, Vol. 47, nr 6, s. 1369-1377Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The treatment of the upper extremities is not as prevalent as that of the lower limbs, but it is nonetheless equally important. Today, there are no load data relating to upper extremity bone-anchored prosthesis users in the literature, but they are important in order to improve the rehabilitation protocol, design aspects and confidence of the user when it comes to loading the prosthesis in daily life. The aim of the present study was to investigate, in a population of eleven transhumeral amputees with osseointegrated implants, the load levels reached during specific prosthetic movements at maximum voluntary effort and during daily activities. The data showed a wide range of maximum load levels throughout the different activities. Furthermore, the data indicate that some test subjects felt apprehensive about loading the prosthesis, resulting in relatively low loads compared with the group as a whole. Within the limits of the present study, it was concluded that loading the implant system was subject specific, which resulted in large subject-to-subject variability. Moreover, some subjects exhibited uncertainty about the levels that could damage the fixation or the implant system. The study illustrates the diversity and uncertainty that exist in a population of transhumeral amputees treated with bone-anchored prostheses in terms of loading in daily life.

  • 14.
    Stenlund, Patrik
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. University of Gothenburg, Sweden.
    Kurosu, Shingo
    Tohoku University, Japan.
    Koizumi, Yuichiro
    Tohoku University, Japan.
    Suska, Felicia
    University of Gothenburg, Sweden.
    Matsumoto, Hiroaki
    Tohoku University, Japan.
    Chiba, Akihiko
    Tohoku University, Japan.
    Palmquist, Anders
    University of Gothenburg, Sweden.
    Osseointegration Enhancement by Zr doping of Co-Cr-Mo Implants Fabricated by Electron Beam Melting2015Inngår i: Additive Manufacturing, ISSN 2214-8604, E-ISSN 2214-7810, Vol. 6, s. 6-15Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Direct osseous healing to prosthetic components is a prerequisite for the clinical success of uncemented treatment in total hip replacements (THR). The demands imposed on the material properties are constantly being stepped up to withstand the impact of an active lifestyle and ensure lifelong integration. Cobalt–chromium–molybdenum (Co-Cr-Mo) materials are interesting for their excellent mechanical stability, corrosion resistance and possibility to be produced by additive manufacturing into complex designs with modifiable stiffness. The bone response to Co-Cr-Mo is regarded as inferior to that of titanium and are usually cemented in THR. The hypothesis in the present study was that a low amount of Zr in the Co-Cr-Mo alloy would improve the bone response and biomechanical anchorage. The results showed significantly higher implant stability for the Co-Cr-Mo alloy with an addition of 0.04% Zr after eight weeks of healing in rabbits, while no major differences were observed in the amount of bone formed around the implants. Further, bone tissue grew into surface irregularities and in direct contact with the implant surfaces. It is concluded that additively manufactured Co-Cr-Mo alloy implants osseointegrate and that the addition of a low amount of Zr to the bulk Co-Cr-Mo further improves the bone anchorage.

  • 15.
    Stenlund, Patrik
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. University of Gothenburg, Sweden.
    Omar, Omar
    University of Gothenburg, Sweden.
    Brohede, Ulrika
    University of Gothenburg, Sweden; Sandvik Coromant R&D, Sweden.
    Norgren, Susanne
    University of Gothenburg, Sweden; Sandvik Coromant R&D, Sweden; Uppsala University, Sweden.
    Norlindh, Birgitta
    University of Gothenburg, Sweden.
    Johansson, Anna
    University of Gothenburg, Sweden.
    Lausmaa, Jukka
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf). University of Gothenburg, Sweden.
    Thomsen, Peter
    University of Gothenburg, Sweden.
    Palmquist, Anders
    University of Gothenburg, Sweden.
    Bone response to a novel Ti-Ta-Nb-Zr alloy2015Inngår i: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 20, s. 165-175Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Commercially pure titanium (cp-Ti) is regarded as the state-of-the-art material for bone-anchored dental devices, whereas the mechanically stronger alloy (Ti–6Al–4V), made of titanium, aluminum (Al) and vanadium (V), is regarded as the material of choice for high-load applications. There is a call for the development of new alloys, not only to eliminate the potential toxic effect of Al and V but also to meet the challenges imposed on dental and maxillofacial reconstructive devices, for example. The present work evaluates a novel, dual-stage, acid-etched, Ti–Ta–Nb–Zr alloy implant, consisting of elements that create low toxicity, with the potential to promote osseointegration in vivo. The alloy implants (denoted Ti–Ta–Nb–Zr) were evaluated after 7 days and 28 days in a rat tibia model, with reference to commercially pure titanium grade 4 (denoted Ti). Analyses were performed with respect to removal torque, histomorphometry and gene expression. The Ti–Ta–Nb–Zr showed a significant increase in implant stability over time in contrast to the Ti. Further, the histological and gene expression analyses suggested faster healing around the Ti–Ta–Nb–Zr, as judged by the enhanced remodeling, and mineralization, of the early-formed woven bone and the multiple positive correlations between genes denoting inflammation, bone formation and remodeling. Based on the present experiments, it is concluded that the Ti–Ta–Nb–Zr alloy becomes osseointegrated to at least a similar degree to that of pure titanium implants. This alloy is therefore emerging as a novel implant material for clinical evaluation.

  • 16.
    Stenlund, Patrik
    et al.
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material. BIOMATCELL VINN Excellence Center of Biomaterials Cell Therapy, Sweden ; University of Gothenburg, Sweden.
    Trobos, Margarita
    BIOMATCELL VINN Excellence Center of Biomaterials Cell Therapy, Sweden ; University of Gothenburg, Sweden.
    Lausmaa, Jukka
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material. BIOMATCELL VINN Excellence Center of Biomaterials Cell Therapy, Sweden .
    Brånemark, Rickard
    BIOMATCELL VINN Excellence Center of Biomaterials Cell Therapy, Sweden ; Sahlgrenska University Hospital, Sweden.
    Thomsen, Peter
    BIOMATCELL VINN Excellence Center of Biomaterials Cell Therapy, Sweden ; University of Gothenburg, Sweden.
    Palmquist, Anders
    BIOMATCELL VINN Excellence Center of Biomaterials Cell Therapy, Sweden ; University of Gothenburg, Sweden.
    Effect of load on the bone around bone-anchored amputation prostheses2017Inngår i: Journal of Orthopaedic Research, ISSN 0736-0266, E-ISSN 1554-527X, Vol. 35, nr 5, s. 1113-1122Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Osseointegrated transfemoral amputation prostheses have proven successful as an alternative method to the conventional socket-type prostheses. The method improves prosthetic use and thus increases the demands imposed on the bone-implant system. The hypothesis of the present study was that the loads applied to the bone-anchored implant system of amputees would result in locations of high stress and strain transfer to the bone tissue and thus contribute to complications such as unfavourable bone remodeling and/or elevated inflammatory response and/or compromised sealing function at the tissue-abutment interface. In the study, site-specific loading measurements were made on amputees and used as input data in finite element analyses to predict the stress and strain distribution in the bone tissue. Furthermore, a tissue sample retrieved from a patient undergoing implant revision was characterized in order to evaluate the long-term tissue response around the abutment. Within the limit of the evaluated bone properties in the present experiments, it is concluded that the loads applied to the implant system may compromise the sealing function between the bone and the abutment, contributing to resorption of the bone in direct contact with the abutment at the most distal end. This was supported by observations in the retrieved clinical sample of bone resorption and the formation of a soft tissue lining along the abutment interface. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1113–1122, 2017.

  • 17.
    Védie, Elora
    et al.
    University de Toulon, France.
    Barry-Martinet, Raphaelle
    University de Toulon, France.
    Senez, Vincent
    University Lille, France.
    Berglin, Mattias
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Stenlund, Patrik
    RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.
    Brisset, Hughes
    Université de Toulon, France.
    Bressy, Christine
    Université de Toulon, France.
    Briand, J-F
    Université de Toulon, France.
    Influence of Sharklet-Inspired Micropatterned Polymers on Spatio-Temporal Variations of Marine Biofouling2022Inngår i: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 22, nr 11, artikkel-id 2200304Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article aims to show the influence of surface characteristics (microtopography, chemistry, mechanical properties) and seawater parameters on the settlement of marine micro- and macroorganisms. Polymers with nine microtopographies, three distinct mechanical properties, and wetting characteristics are immersed for one month into two contrasting coastal sites (Toulon and Kristineberg Center) and seasons (Winter and Summer). Influence of microtopography and chemistry on wetting is assessed through static contact angle and captive air bubble measurements over 3-weeks immersion in artificial seawater. Microscopic analysis, quantitative flow cytometry, metabarcoding based on the ribulose biphosphate carboxylase (rbcL) gene amplification, and sequencing are performed to characterize the settled microorganisms. Quantification of macrofoulers is done by evaluating the surface coverage and the type of organism. It is found that for long static in situ immersion, mechanical properties and non-evolutive wettability have no major influence on both abundance and diversity of biofouling assemblages, regardless of the type of organisms. The apparent contradiction with previous results, based on model organisms, may be due to the huge diversity of marine environments, both in terms of taxa and their size. Evolutive wetting properties with wetting switching back and forth over time have shown to strongly reduce the colonization by macrofoulers. © 2022 The Authors. 

  • 18.
    Yoshimatsu, K.
    et al.
    Lund University.
    Ye, L.
    Lund University.
    Stenlund, Patrik
    RISE - Research Institutes of Sweden, Swerea, Swerea IVF AB.
    Chronakis, Ioannis
    RISE - Research Institutes of Sweden, Swerea, Swerea IVF AB.
    A simple method for preparation of molecularly imprinted nanofiber materials with signal transduction ability2008Inngår i: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, nr 17, s. 2022-2024Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A simple electrospinning method is developed to introduce signal transduction ability into molecularly imprinted nanofibers. © The Royal Society of Chemistry.

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