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  • 1. Ballo, A
    et al.
    Agheli, H
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Thomsen, P
    Petronis, S
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Nanostructured model implants for in vivo studies: influence of well-defined nanotopoghraphy on de novo bone formation on titanium implants2011In: International Journal of Nanomedicine, ISSN 1176-9114, E-ISSN 1178-2013, Vol. 6, no 1, p. 3415-3428Article in journal (Refereed)
    Abstract [en]

    An implantable model system was developed to investigate the effects of nanoscale surface properties on the osseointegration of titanium implants in rat tibia. Topographical nanostructures with a well-defined shape (semispherical protrusions) and variable size (60 nm, 120 nm and 220 nm) were produced by colloidal lithography on the machined implants. Furthermore, the implants were sputter-coated with titanium to ensure a uniform surface chemical composition. The histological evaluation of bone around the implants at 7 days and 28 days after implantation was performed on the ground sections using optical and scanning electron microscopy. Differences between groups were found mainly in the new bone formation process in the endosteal and marrow bone compartments after 28 days of implantation. Implant surfaces with 60 nm features demonstrated significantly higher bone-implant contact (BIC, 76%) compared with the 120 nm (45%) and control (57%) surfaces. This effect was correlated to the higher density and curvature of the 60 nm protrusions. Within the developed model system, nanoscale protrusions could be applied and systematically varied in size in the presence of microscale background roughness on complex screw-shaped implants. Moreover, the model can be adapted for the systematic variation of surface nanofeature density and chemistry, which opens up new possibilities for in vivo studies of various nanoscale surface-bone interactions.

  • 2.
    Ballo, Ahmed Mansour
    et al.
    Sahlgrenska Academy, Sweden.
    Björn, Dorota
    Sandvik, Sweden.
    Åstrand, Maria
    Sandvik, Sweden.
    Palmquist, Anders
    Sahlgrenska Academy, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Thomsen, Peter
    Sahlgrenska Academy, Sweden.
    Bone response to physical-vapour-deposited titanium dioxide coatings on titanium implants2013In: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 24, no 9, p. 1009-1017Article in journal (Refereed)
    Abstract [en]

    Objectives: The aim of this study was to investigate the correlation between coating thickness and the crystal structure of physical-vapour-deposited (PVD) titanium dioxide coatings, and to evaluate their in vivo biocompatibility. Materials and methods: The PVD TiO 2 coatings of different thickness were deposited on machined titanium grade 2 screw-shaped implants. Non-coated titanium implants were used as controls. Coating properties such as thickness, crystal structure, coating morphology and roughness were characterized. Forty-eight implants were placed randomly into both tibias of 16 rats. The animals were euthanized 7 and 28 days postsurgery and block biopsies were prepared for histology, histomorphometry and SEM analysis. Results: The thicknesses of the PVDTiO 2 coatings were 120 and 1430 nm respectively. Histologically, new bone formed on all implant surfaces. The mean percentage of newly formed bone in contact with the implant (BIC) was significantly higher at early healing time (7 days) for the 120 nm thick PVD coating (39 ± 14%) than for both the 1430 nm thick PVD coating (22 ± 10%) (P = 0.043) and the machined surface (22 ± 9%) (P = 0.028). This difference was no longer evident after 28 days (P = 0.867). Conclusion: Bone formation and bone-to-implant contact are achieved to the same degree for TiO 2 surface modifications prepared by a PVD process as clinically used, machined titanium. Furthermore, a relatively thinner PVD coating promotes a higher degree of bone apposition shortly after implantation, thereby providing rationales for exploring the potential clinical use of these modifications.

  • 3.
    Ballo, Ahmed Mansour
    et al.
    University of British Columbia, Canada; College of Dentistry at King Saud University, Saudi Arabia.
    Cekic-Nagas, Isil
    Gazi University, Turkey.
    Ergün, Gülfem
    Gazi University, Turkey.
    Lassila, Lippo Veli Juhana
    University of Turku, Finland.
    Palmquist, Anders
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Borchardt, Per
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Organisk kemi (Kmo). BIOMATCELL, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf). BIOMATCELL, Sweden.
    Thomsen, Peter
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Vallittu, Pekka Kalevi
    University of Turku, Finland.
    Närhi, Timo O.
    University of Turku, Finland; Turku University Central Hospital, Finland.
    Osseointegration of fiber-reinforced composite implants: Histological and ultrastructural observations2014In: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 30, no 12, p. e384-e395Article in journal (Refereed)
    Abstract [en]

    Objectives. The aim of this study was to evaluate the bone tissue response to fiber-reinforced composite (FRC) in comparison with titanium (Ti) implants after 12 weeks of implantation in cancellous bone using histomorphometric and ultrastructural analysis. Materials and methods. Thirty grit-blasted cylindrical FRC implants with BisGMA-TEGDMA polymer matrix were fabricated and divided into three groups: (1) 60 s light-cured FRC (FRC-L group), (2) 24 h polymerized FRC (FRC group), and (3) bioactive glass FRC (FRC-BAG group). Titanium implants were used as a control group. The surface analyses were performed with scanning electron microscopy and 3D SEM. The bone-implant contact (BIC) and bone area (BA) were determined using histomorphometry and SEM. Transmission electron microscopy (TEM) was performed on Focused Ion Beam prepared samples of the intact bone-implant interface. Results. The FRC, FRC-BAG and Ti implants were integrated into host bone. In contrast, FRC-L implants had a consistent fibrous capsule around the circumference of the entire implant separating the implant from direct bone contact. The highest values of BIC were obtained with FRC-BAG (58 ± 11%) and Ti implants (54 ± 13%), followed by FRC implants (48 ± 10%), but no significant differences in BIC or BA were observed (p = 0.07, p = 0.06, respectively). TEM images showed a direct contact between nanocrystalline hydroxyapatite of bone andboth FRC and FRC-BAG surfaces. Conclusion. Fiber-reinforced composite implants are capable of establishing a close bone contact comparable with the osseointegration of titanium implants having similar surface roughness.

  • 4.
    Bredberg, Anna
    et al.
    University of Gothenburg, Sweden.
    Josefson, Mats
    AstraZeneca, Sweden.
    Almstrand, Ann Charlotte
    University of Gothenburg, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Levinsson, Anna
    University of Gothenburg, Sweden.
    Larsson, Per
    University of Gothenburg, Sweden.
    Olin, Anna Carin
    University of Gothenburg, Sweden.
    Comparison of exhaled endogenous particles from smokers and non-smokers using multivariate analysis2013In: Respiration, ISSN 0025-7931, E-ISSN 1423-0356, Vol. 86, no 2, p. 135-142Article in journal (Refereed)
    Abstract [en]

    Background: Smoking, along with many respiratory diseases, has been shown to induce airway inflammation and alter the composition of the respiratory tract lining fluid (RTLF). We have previously shown that the phospholipid and protein composition of particles in exhaled air (PEx) reflects that of RTLF. In this study, we hypothesized that the composition of PEx differs between smokers and non-smokers, reflecting inflammation in the airways. Objective: It was the aim of this study to identify differences in the phospholipid composition of PEx from smokers and non-smokers. Methods: PEx from 12 smokers and 13 non-smokers was collected using a system developed in-house. PEx was analysed using time-of-flight secondary ion mass spectrometry, and the mass spectral data were evaluated using multivariate analysis. Orthogonal partial least squares (OPLS) was used to relate smoking status, lung function and pack years to the chemical composition of RTLF. The discriminating ions identified by OPLS were then used as explanatory variables in traditional regression analysis. Results: There was a clear discrimination between smokers and non-smokers according to the chemical composition, where phospholipids from smokers were protonated and sodiated to a larger extent. Poor lung function showed a strong association with higher response from all molecular phosphatidylcholine species in the samples. Furthermore, the accumulated amount of tobacco consumed was associated with variations in mass spectra, indicating a dose-response relationship. Conclusion: The chemical composition of PEx differs between smokers and non-smokers, reflecting differences in the RTLF. The results from this study may suggest that the composition of RTLF is affected by smoking and may be of importance for lung function.

  • 5. Bryne, Lars Elof
    et al.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Ernstsson, Marie
    Englund, Finn
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, Trätek.
    Wålinder, Magnus
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, Trätek.
    Ageing of modified wood. Part 2: Determination of surface composition of acetylated, furfurylated, and thermally modified wood by XPS and ToF-SIMS2010In: Holzforschung, ISSN 0018-3830, E-ISSN 1437-434X, Vol. 64, no 3, p. 305–313-Article in journal (Refereed)
    Abstract [en]

    The main objective of this work was to study the chemical composition of surfaces and ageing effects on acetylated pine (Pinus sylvestris), heat treated spruce (Picea abies), and furfurylated radiata pine (Pinus radiata) in comparison to unmodified wood. X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) were the instruments of choice. Observation with a low-vacuum scanning electron microscope (LV-SEM) complemented the study. The spectroscopic information was also linked to a parallel wettability study on matched wood samples by the Wilhelmy method. The results show that XPS and ToF-SIMS are two powerful tools that in combination give complementary information, both quantitative and qualitative, and are well suited for observation of the ageing process of different wood surfaces. The hydrophobization process as a result of migration of extractives during ageing was well quantified by the XPS measurements and the results correlated well with wetting results. Several specific hydrophobic substances could be identified by ToF-SIMS measurements.

  • 6. Bryne, Lars Elof
    et al.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Ernstsson, Marie
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Englund, Finn
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP - Sveriges Tekniska Forskningsinstitut, SP Trä.
    Wålinder, Magnus
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP - Sveriges Tekniska Forskningsinstitut, SP Trä.
    Söderström, Ove
    UV-laser irradiated wood - Some aspects on micromorphology, wettability, surface composition and liquid permeability2008In: 4th meeting of the Nordic Baltic Network in Wood Material Science and Engineering (WSE), Latvian State Instiute of Wood Chemistry , 2008, , p. 75-82Conference paper (Other academic)
  • 7. Carlsson, Lennart
    et al.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    A cell preparation method allowing subcellular localization of cholesterol and phosphocholine with imaging ToF-SIMS2003In: Colloids and Surfaces B: Biointerface, Vol. 30, no 30, p. 87-92Article in journal (Refereed)
    Abstract [en]

    A cell preparation method allowing subcellular localization of cholesterol and phosphocholine with imaging ToF-SIMS

  • 8.
    de Peppo, Giuseppe Maria
    et al.
    The New York Stem Cell Foundation Research Institute, USA; Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Agheli, Hossein
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Karlsson, Camilla
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Ekström, Karin
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Brisby, Helena
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Lennerås, Maria E.
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Gustafsson, Stefan
    BIOMATCELL, Sweden; Chalmers University of Technology, Sweden.
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Johansson, Anna Karin
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Olsson, Eva
    BIOMATCELL, Sweden; Chalmers University of Technology, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Thomsen, Peter
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Petronis, Sarunas
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. BIOMATCELL, Sweden.
    Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro2014In: International Journal of Nanomedicine, ISSN 1176-9114, E-ISSN 1178-2013, Vol. 9, no 1, p. 2499-2515Article in journal (Refereed)
    Abstract [en]

    Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role inthe osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Results: We found that the proliferation and osteogenicdifferentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.

  • 9.
    Englund, Finn
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, Trätek.
    Bryne, Lars Elof
    Ernstsson, Marie
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Wålinder, Magnus
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, Trätek.
    Some aspects on the determination of surface chemical composition and wettability of modified wood2009In: Proceedings of The Fourth European Conference on Wood Modification., SP Technical Research Institute of Sweden , 2009, , p. 553-560Conference paper (Other academic)
  • 10.
    Englund, Finn
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, Trätek.
    Bryne, Lars Elof
    Ernstsson, Marie
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Wålinder, Magnus
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, Trätek.
    Some aspects on the determination of surface chemical composition and wettability of modified wood2009In: Wood Material Science & Engineering, ISSN 1748-0272, E-ISSN 1748-0280, Vol. 4, no 1-2, p. 80-85Article in journal (Refereed)
  • 11.
    Englund, Finn
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, Trätek.
    Bryne, Lars Elof
    Ernstsson, Marie
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Wålinder, Magnus
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP - Sveriges Tekniska Forskningsinstitut, SP Trä.
    Spectroscopic studies of surface chemical composition and wettability of modified wood2009In: Wood Material Science & Engineering, ISSN 1748-0272, E-ISSN 1748-0280, Vol. 4, no 1-2, p. 80–85-Article in journal (Refereed)
  • 12.
    Hansson, Petra
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Jansson, S
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Berg, G
    Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine: Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry2012In: Case Reports in Endocrinology, ISSN 2090-6501, E-ISSN 2090-651X, Vol. 2012, article id art. ID 842357Article in journal (Refereed)
  • 13.
    Hoseini, Mohammed
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Hållfasthet (BMh).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    A new screening method for the tribological investigation of artificial joints2001In: Tribology in biomechanical systems. Proceedings of 2nd World Tribology Congress, Vienna, September 3-7, 2001, 2001Conference paper (Other academic)
  • 14.
    Hoseini, Mohammed
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Hållfasthet (BMh).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Tribological investigation of oriented HDPE2002In: Journal of Biomedical Materials Research, Vol. 61, no 4, p. 6-Article in journal (Other academic)
  • 15.
    Hoseini, Mohammed
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Hållfasthet (BMh).
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Boldizar, Antal
    Tribological investigation of oriented HDPE1999In: Proc. Polymer Processing Society, Asia/Australia Regional Meeting, Bangkok, Dec. 1999., 1999, , p. 109-111Conference paper (Other academic)
  • 16. Hulander, M
    et al.
    Lundgren, A
    Berglin, Mattias
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Ohrlander, M
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Elwing, H
    Immune complement activation is attenuated by surface nanotopography2011In: International Journal of Nanomedicine, ISSN 1176-9114, E-ISSN 1178-2013, Vol. 6, p. 2653-2666Article in journal (Refereed)
    Abstract [en]

    The immune complement (IC) is a cell-free protein cascade system, and the first part of the innate immune system to recognize foreign objects that enter the body. Elevated activation of the system from, for example, biomaterials or medical devices can result in both local and systemic adverse effects and eventually loss of function or rejection of the biomaterial. Here, the researchers have studied the effect of surface nanotopography on the activation of the IC system. By a simple nonlithographic process, gold nanoparticles with an average size of 58 nm were immobilized on a smooth gold substrate, creating surfaces where a nanostructure is introduced without changing the surface chemistry. The activation of the IC on smooth and nanostructured surfaces was viewed with fluorescence microscopy and quantified with quartz crystal microbalance with dissipation monitoring in human serum. Additionally, the ability of pre-adsorbed human immunoglobulin G (IgG) (a potent activator of the IC) to activate the IC after a change in surface hydrophobicity was studied. It was found that the activation of the IC was significantly attenuated on nanostructured surfaces with nearly a 50% reduction, even after pre-adsorption with IgG. An increase in surface hydrophobicity blunted this effect. The possible role of the curvature of the nanoparticles for the orientation of adsorbed IgG molecules, and how this can affect the subsequent activation of the IC, are discussed. The present findings are important for further understanding of how surface nanotopography affects complex protein adsorption, and for the future development of biomaterials and blood-contacting devices.

  • 17.
    Karlsson, Joakim
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. Uppsala University, Sweden.
    Norell, Mats
    Chalmers University of Technology, Sweden.
    Ackelid, Ulf
    Arcam AB, Sweden.
    Engqvist, Håkan
    Uppsala University, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Surface oxidation behavior of Ti-6Al-4V manufactured by Electron Beam Melting (EBM®)2015In: Journal of Manufacturing Processes, ISSN 1526-6125, Vol. 17, p. 120-126Article in journal (Refereed)
    Abstract [en]

    Additive manufacturing is an emerging manufacturing technology that enables production of patient specific implants, today primarily out of titanium. For optimal functionality and proper integration between the titanium implant and the body tissues surface properties, such as surface oxide thickness is of particular importance, as it is primarily the surface of the material which interacts with the body. Hence, in this study the surface oxidation behavior of titanium parts manufactured by Electron Beam Melting (EBM®) is investigated using the surface sensitive techniques ToF-SIMS and AES. Oxide thicknesses comparable to those found on conventionally machined surfaces are found by both analysis techniques. However, a build height dependency is discovered for different locations of the EBM® manufactured parts due to the presence of trapped moisture in the machine and temperature gradients in the build.

  • 18.
    Karlsson, Joakim
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut. Arcam AB, Sweden.
    Sjögren, Torsten
    RISE, SP – Sveriges Tekniska Forskningsinstitut.
    Snis, Anders
    Arcam AB, Sweden.
    Engqvist, Håkån
    Uppsala University, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Digital image correlation analysis of local strain fields on Ti6Al4V manufactured by electron beam melting2014In: Materials Science & Engineering: A, ISSN 0921-5093, E-ISSN 1873-4936, Vol. 618, p. 456-461Article in journal (Refereed)
    Abstract [en]

    Additive manufacturing, or 3D-printing as it is often called, build parts in a layer-by-layer fashion. A common concern, regardless of the specific additive manufacturing technique used, is the risk of inadequate fusion between the adjacent layers which in turn may cause inferior mechanical properties. In this work, the local strain properties of titanium parts produced by Electron Beam Melting (EBM®) were studied in order to gain information about the quality of fusion of the stock powder material used in the process. By using Digital Image Correlation (DIC) the strain fields in the individual layers were analyzed, as well as the global strain behavior of the bulk material. The results show that fully solid titanium parts manufactured by EBM are homogenous and do not experience local deformation behavior, neither on local nor on a global level.

  • 19.
    Karlsson, Joakim
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. Uppsala University, Sweden.
    Snis, Anders
    Arcam AB, Sweden.
    Engqvist, Håkan
    Uppsala University, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Characterization and comparison of materials produced by Electron Beam Melting (EBM) of two different Ti-6Al-4V powder fractions2013In: Journal of Materials Processing Technology, ISSN 0924-0136, E-ISSN 1873-4774, Vol. 213, no 12, p. 2109-2118Article in journal (Refereed)
    Abstract [en]

    Electron Beam Melting (EBM) has been recognized as a revolutionary technique to produce mass-customized parts to near-net-shape from various metallic materials. The technique produces parts with unique geometries from a powder stock material and uses an electron beam to melt the powder layer-by-layer to fully solid structures. In this study we have investigated the use of two different Ti-6Al-4V powders of different size fractions in the EBM process; a larger 45-100 μm powder, and a smaller 25-45 μm powder. We have also investigated the effects of two build layer thicknesses, 70 μm and 50 μm, respectively. We hypothesize that the smaller powder has the potential to improve surface resolution of parts produced in the EBM process. The EBM as-built parts were investigated regarding surface and bulk chemistry, surface oxide thickness, macro- and microstructure, surface appearance and mechanical properties. We conclude from the results that both powders and both build layer thicknesses are feasible to use in the EBM process. The investigated material properties were not significantly affected by powder size or layer thickness within the studied range of process parameters. However, the surface appearance was found to be different for the samples made with the different powder sizes.

  • 20.
    Larsson Wexell, Cecilia
    et al.
    University of Gothenburg, Sweden; Södra Älvsborgs sjukhus, Sweden; Sahlgrenska Academy, Sweden.
    Thomsen, Peter
    University of Gothenburg, Sweden; Södra Älvsborgs sjukhus, Sweden; BIOMATCELL, Sweden.
    Aronsson, Björn Owe
    Chalmers University of Technology, Sweden; Nano Bridging Molecules SA, Switzerland.
    Tengvall, Pentti
    Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden; Linköping University, Sweden.
    Rodahl, Michael
    Chalmers University of Technology, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf). Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
    Bone response to surface-modified titanium implants: Studies on the early tissue response to implants with different surface characteristics2013In: International Journal of Biomaterials, ISSN 1687-8787, E-ISSN 1687-8795, article id 412482Article in journal (Refereed)
    Abstract [en]

    In a series of experimental studies, the bone formation around systematically modified titanium implants is analyzed. In the present study, three different surface modifications were prepared and evaluated. Glow-discharge cleaning and oxidizing resulted in a highly stoichiometric TiO2 surface, while a glow-discharge treatment in nitrogen gas resulted in implants with essentially a surface of titanium nitride, covered with a very thin titanium oxide. Finally, hydrogen peroxide treatment of implants resulted in an almost stoichiometric TiO2, rich in hydroxyl groups on the surface. Machined commercially pure titanium implants served as controls. Scanning Auger Electron Spectroscopy, Scanning Electron Microscopy, and Atomic Force Microscopy revealed no significant differences in oxide thickness or surface roughness parameters, but differences in the surface chemical composition and apparent topography were observed. After surface preparation, the implants were inserted in cortical bone of rabbits and evaluated after 1, 3, and 6 weeks. Light microscopic evaluation of the tissue response showed that all implants were in contact with bone and had a large proportion of newly formed bone within the threads after 6 weeks. There were no morphological differences between the four groups. Our study shows that a high degree of bone contact and bone formation can be achieved with titanium implants of different surface composition and topography.

  • 21.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Bone tissue reactions to biomimetic ion-substituted apatite surfaces on titanium implants2012In: Journal of the Royal Society Interface, ISSN 1742-5689, E-ISSN 1742-5662, Vol. 9, no 72, p. 1615-1624Article in journal (Refereed)
  • 22.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Commercially available dental implants: Review of their surface characteristics2012In: Journal of Biomaterials and Tissue Engineering, ISSN 2157-9083, E-ISSN 2157-9091, Vol. 2, no 2, p. 112-124Article in journal (Refereed)
  • 23.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Contamination of polyethylene cups with polymethylmethacrylate particles”2001In: The Journal of Arthroplasty, ISSN 0883-5403, E-ISSN 1532-8406, Vol. 16, no 7, p. 905-908Article in journal (Other academic)
  • 24.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Contamination of polyethylene cups with polymethylmethacrylate particles. (An experimental study)1999Conference paper (Other academic)
  • 25.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Crystallization kinetics of thin amorphous water films on surfaces: theory and computer modeling2004In: Phys. Chem. Chem. Phys, Vol. 6, p. 1890-1898Article in journal (Other academic)
  • 26.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Highly packed and aligned fluoride substituted hydroxyapatite via a surfactant-free process2012In: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981, Vol. 100, no 1, p. 75-81Article in journal (Refereed)
  • 27.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Impact of nanostructure on bacterial adhesion and EPS production2011In: European Cells and Materials, ISSN 1473-2262, E-ISSN 1473-2262, Vol. 21, no S1, p. 42-Article in journal (Refereed)
  • 28.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Impact of polymer surface affinity of novel antifouling agents2004In: Biotechnology and Bioengineering, Vol. 86, p. 1-8Article in journal (Refereed)
  • 29.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Incorporation of active ions into calcium phosphate coatings, their release behavior and mechanism2012In: Biomedical Materials, ISSN 1748-6041, E-ISSN 1748-605X, Vol. 7, no 4, p. 45018-Article in journal (Refereed)
  • 30.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Increased wear of UHMWPE caused by calcium phosphate precipitation2001In: Proceedings of 17th European Biomaterials Conference, London, England, September 12-14, 2001, 2001Conference paper (Other academic)
  • 31.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Influence of well-defined titanium-coated topographical nanostructures on bone formation in vivo2011In: European Cells and Materials, ISSN 1473-2262, E-ISSN 1473-2262, Vol. 21, no S1, p. 17-Article in journal (Refereed)
  • 32.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Interaction between dendrimers and thin polymer films studied by TOF-SIMS2001Conference paper (Other academic)
  • 33.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Interaction of anti-barnacle drugs (catemines) with components in marine paint formulations2000Conference paper (Other academic)
  • 34.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Interactions between human whole blood and modified TiO2 surfaces: Influence of surface topography and oxide thickness on leukocyte adhesion and activation2001In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 22, no 14, p. 1987-1996Article in journal (Other academic)
  • 35.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Nanostructured noble metals on implants in vitro and in vivo2011In: European Cells and Materials, ISSN 1473-2262, E-ISSN 1473-2262, Vol. 21, no S1, p. 50-Article in journal (Refereed)
  • 36.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Properties of thin high-density polyethylene films prepared by spin coating1999In: Polymeric materials science and engineering, ISSN 0743-0515, Vol. 80, p. 398-399Article in journal (Other academic)
  • 37.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Spin coating and characterization of thin high-density polyethylene films2001In: Macromolecules, ISSN 0024-9297, E-ISSN 1520-5835, Vol. 34, no 21, p. 7496-7503Article in journal (Other academic)
  • 38.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Structure and surface of TiNi human implants2001In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 22, no 15, p. 2131-2138Article in journal (Other academic)
  • 39.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Surface modification of spin-coated high-density polyethylene films by argon and oxygen glow discharge treatments2002In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 202, p. 92-103Article in journal (Other academic)
  • 40.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    The stimulation of an osteogenic response by classical monocyte activation2011In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 32, no 32, p. 8190-8204Article in journal (Refereed)
  • 41.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    TOF-SIMS characterization of a number of different liquid chromatographic media aimed for purification of biotheraputics2001In: 13th International Conference on Secondary Ion Mass Spectrometry and Related Topics (SIMS XIII), Nara, Japan, November 11-16, 2001. Proceedings, 2001Conference paper (Other academic)
  • 42.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Tribological investigation of oriented HDPE1999In: Proc. Annual ACS Spring Meetings. Div. Polymer Science and Engineering, 1999Conference paper (Other academic)
  • 43.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    UV-light treatment of thin high-density polyethylene films monitored by quartz crystal microbalance2004In: Journal of Applied Polymer Science, Vol. 92, p. 2833-2839Article in journal (Refereed)
  • 44.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Boldizar, Antal
    TOF-SIMS study of injection-moulded polystyrene2003In: Journal of Polymer and Engineering & Science, Vol. 43, p. 1289-1297Article in journal (Refereed)
    Abstract [en]

    TOF-SIMS study of injection-moulded polystyrene

  • 45.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Boldizar, Antal
    Tribological investigation of oriented HDPE2002In: Journal of Biomedical Materials Research, ISSN 0021-9304, E-ISSN 1097-4636, Vol. 61, no 4, p. 634-640Article in journal (Other academic)
  • 46.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Borchardt, Per
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Organisk kemi (Kmo).
    Free-form-fabricated commercially pure Ti and Ti6Al4V porous scaffolds support the growth of human embryonic stem cell-derived mesodermal progenitors2012In: Scientific World Journal, E-ISSN 1537-744X, Vol. 2012, p. 646417-Article in journal (Refereed)
  • 47.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Hansson, M
    Grunditz, T
    Isaksson, Mats
    Jansson, Svante
    Mölne, Johan
    Berg, G
    Iodine Content and Distribution in Extratumoral and Tumor Thyroid Tissue Analyzed with X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry2008In: Thyroid., Vol. 18, no 11, p. 1215-1220Article in journal (Refereed)
  • 48.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Siljeström, Sandra
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Hode, Tomas
    Toporski, Jan
    Thiel, Volker
    Detection of organic biomarkers in crude oil using ToF-SIMS2009In: Organic Geochemistry, Vol. 40, p. 135-143Article in journal (Refereed)
  • 49.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Analysis of archaeal core ether lipids using time-of-flight secondary ion mass spectrometry (ToF-SIMS): Exploring a new concept for the study of biomarkers in geobiology2007In: Geobiology, Vol. 5, p. 75-83Article in journal (Refereed)
  • 50.
    Lausmaa, Jukka
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Sjövall, Peter
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Ancient microbial activity recorded in fracture fillings from granitic rocks (Äspö Hard Rock Laboratory, Sweden)2012In: Geobiology, ISSN 1472-4677, E-ISSN 1472-4669, Vol. 10, no 4, p. 280-297Article in journal (Refereed)
12 1 - 50 of 89
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