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  • 1.
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Gold-nanoparticle-assisted self-assembly of chemical gradients with tunable sub-50 nm molecular domains2014Ingår i: Particle & particle systems characterization, ISSN 0934-0866, E-ISSN 1521-4117, Vol. 31, nr 2, s. 209-218Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A simple and efficient principle for nanopatterning with wide applicability in the sub-50 nanometer regime is chemisorption of nanoparticles; at homogeneous substrates, particles carrying surface charge may spontaneously self-organize due to the electrostatic repulsion between adjacent particles. Guided by this principle, a method is presented to design, self-assemble, and chemically functionalize gradient nanopatterns where the size of molecular domains can be tuned to match the level corresponding to single protein binding events. To modulate the binding of negatively charged gold nanoparticles both locally (<100 nm) and globally (>100 μm) onto a single modified gold substrate, ion diffusion is used to achieve spatial control of the particles' mutual electrostatic interactions. By subsequent tailoring of different molecules to surface-immobilized particles and the void areas surrounding them, nanopatterns are obtained with variable chemical domains along the gradient surface. Fimbriated Escherichia coli bacteria are bound to gradient nanopatterns with similar molecular composition and macroscopic contact angle, but different sizes of nanoscopic presentation of adhesive (hydrophobic) and repellent poly(ethylene) glycol (PEG) domains. It is shown that small hydrophobic domains, similar in size to the diameter of the bacterial fimbriae, supported firmly attached bacteria resembling catch-bond binding, whereas a high number of loosely adhered bacteria are observed on larger hydrophobic domains. Chemical gradients with the resolution needed to address complex biological binding events at the single protein level are prepared using surface-deposited gold nanoparticles as a versatile template for orthogonal chemicalmodifications. The effect of hydrophobic domain arrangement on the sub-50 nm scale is shown to influence binding of fimbriae carrying E. coli bacteria. 

  • 2.
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Gradients in surface nanotopography used to study platelet adhesion and activation2013Ingår i: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 110, nr 1, s. 261-269Artikel i tidskrift (Refereegranskat)
  • 3.
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Pellet formation of zygomycetes and immobilization of yeast2013Ingår i: New Biotechnology, ISSN 1871-6784, E-ISSN 1876-4347, Vol. 30, nr 5, s. 516-522Artikel i tidskrift (Refereegranskat)
  • 4.
    Dahlström, Mia
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Sjögren, Martin
    Uppsala University, Sweden.
    Jonsson, Per R.
    University of Gothenburg, Sweden.
    Göransson, Ulf
    Uppsala University, Sweden.
    Lindh, Liselott
    Malmö University, Sweden.
    Arnebrant, Thomas
    Malmö University, Sweden.
    Pinori, Emiliano
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Elwing, Hans
    University of Gothenburg, Sweden.
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Affinity states of biocides determine bioavailability and release rates in marine paints2015Ingår i: Biofouling (Print), ISSN 0892-7014, E-ISSN 1029-2454, Vol. 31, nr 2, s. 201-210Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A challenge for the next generation marine antifouling (AF) paints is to deliver minimum amounts of biocides to the environment. The candidate AF compound medetomidine is here shown to be released at very low concentrations, ie ng ml(-1) day(-1). Moreover, the release rate of medetomidine differs substantially depending on the formulation of the paint, while inhibition of barnacle settlement is independent of release to the ambient water, ie the paint with the lowest release rate was the most effective in impeding barnacle colonisation. This highlights the critical role of chemical interactions between biocide, paint carrier and the solid/aqueous interface for release rate and AF performance. The results are discussed in the light of differential affinity states of the biocide, predicting AF activity in terms of a high surface affinity and preserved bioavailability. This may offer a general framework for the design of low-release paint systems using biocides for protection against biofouling on marine surfaces.

  • 5.
    Fromell, Karin
    et al.
    Uppsala University, Sweden.
    Yang, Yi
    University of Gothenburg, Sweden.
    Nilsson Ekdahl, Kristina
    Linnaeus University, Sweden.
    Nilsson, Bo
    Linnaeus University, Sweden.
    Berglin, Mattias
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
    Elwing, Hans
    University of Gothenburg, Sweden.
    Absence of conformational change in complement factor 3 and factor XII adsorbed to acrylate polymers is related to a high degree of polymer backbone flexibility2017Ingår i: Biointerphases, ISSN 1934-8630, E-ISSN 1559-4106, Vol. 12, nr 2, artikel-id 02D417Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In previous investigations, the authors have examined the adsorption of albumin, immunoglobulin, and fibrinogen to a series of acrylate polymers with different backbone and side-group flexibility. The authors showed that protein adsorption to acrylates with high flexibility, such as poly(lauryl methacrylate) (PLMA), tends to preserve native conformation. In the present study, the authors have continued this work by examining the conformational changes that occur during the binding of complement factor 3 (C3) and coagulation factor XII (FXII). Native C3 adsorbed readily to all solid surfaces tested, including a series of acrylate surfaces of varying backbone flexibility. However, a monoclonal antibody recognizing a "hidden" epitope of C3 (only exposed during C3 activation or denaturation) bound to the C3 on the rigid acrylate surfaces or on polystyrene (also rigid), but not to C3 on the flexible PLMA, indicating that varying degrees of conformational change had occurred with binding to different surfaces. Similarly, FXII was activated only on the rigid poly(butyl methacrylate) surface, as assessed by the formation of FXIIa-antithrombin (AT) complexes; in contrast, it remained in its native form on the flexible PLMA surface. The authors also found that water wettability hysteresis, defined as the difference between the advancing and receding contact angles, was highest for the PLMA surface, indicating that a dynamic change in the interface polymer structure may help protect the adsorbed protein from conformational changes and denaturation.

  • 6. Gruner, MS
    et al.
    Szilvay, GR
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Lienemann, M
    Laaksonen, P
    Linder, MB
    Self-assembly of class II hydrophobins on polar surfaces2012Ingår i: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 28, nr 9, s. 4293-4300Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Hydrophobins are structural proteins produced by filamentous fungi that are amphiphilic and function through self-assembling into structures such as membranes. They have diverse roles in the growth and development of fungi, for example in adhesion to substrates, for reducing surface tension to allow aerial growth, in forming protective coatings on spores and other structures. Hydrophobin membranes at the air-water interface and on hydrophobic solids are well studied, but understanding how hydrophobins can bind to a polar surface to make it more hydrophobic has remained unresolved. Here we have studied different class II hydrophobins for their ability to bind to polar surfaces that were immersed in buffer solution. We show here that the binding under some conditions results in a significant increase of water contact angle (WCA) on some surfaces. The highest contact angles were obtained on cationic surfaces where the hydrophobin HFBI has an average WCA of 62.6° at pH 9.0, HFBII an average of 69.0° at pH 8.0, and HFBIII had an average WCA of 61.9° at pH 8.0. The binding of the hydrophobins to the positively charged surface was shown to depend on both pH and ionic strength. The results are significant for understanding the mechanism for formation of structures such as the surface of mycelia or fungal spore coatings as well as for possible technical applications. .

  • 7. Hulander, M
    et al.
    Lundgren, A
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Ohrlander, M
    Lausmaa, Jukka
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Elwing, H
    Immune complement activation is attenuated by surface nanotopography2011Ingår i: International Journal of Nanomedicine, ISSN 1176-9114, E-ISSN 1178-2013, Vol. 6, s. 2653-2666Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The immune complement (IC) is a cell-free protein cascade system, and the first part of the innate immune system to recognize foreign objects that enter the body. Elevated activation of the system from, for example, biomaterials or medical devices can result in both local and systemic adverse effects and eventually loss of function or rejection of the biomaterial. Here, the researchers have studied the effect of surface nanotopography on the activation of the IC system. By a simple nonlithographic process, gold nanoparticles with an average size of 58 nm were immobilized on a smooth gold substrate, creating surfaces where a nanostructure is introduced without changing the surface chemistry. The activation of the IC on smooth and nanostructured surfaces was viewed with fluorescence microscopy and quantified with quartz crystal microbalance with dissipation monitoring in human serum. Additionally, the ability of pre-adsorbed human immunoglobulin G (IgG) (a potent activator of the IC) to activate the IC after a change in surface hydrophobicity was studied. It was found that the activation of the IC was significantly attenuated on nanostructured surfaces with nearly a 50% reduction, even after pre-adsorption with IgG. An increase in surface hydrophobicity blunted this effect. The possible role of the curvature of the nanoparticles for the orientation of adsorbed IgG molecules, and how this can affect the subsequent activation of the IC, are discussed. The present findings are important for further understanding of how surface nanotopography affects complex protein adsorption, and for the future development of biomaterials and blood-contacting devices.

  • 8.
    Lindgren, J. Fredrik
    et al.
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
    Ytreberg, Erik
    Chalmers University of Technology, Sweden.
    Holmqvist, Albin
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
    Dahlström, Magnus
    Chalmers University of Technology, Sweden.
    Dahl, Peter
    University of Gothenburg, Sweden.
    Berglin, Mattias
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
    Wrange, Anna-Lisa
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
    Dahlström, Mia
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
    Copper release rate needed to inhibit fouling on the west coast of Sweden and control of copper release using zinc oxide2018Ingår i: Biofouling (Print), ISSN 0892-7014, E-ISSN 1029-2454, Vol. 34, nr 4, s. 453-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    How zinc oxide influences copper release has been tested and the lowest release rate of copper from various combinations of copper and zinc in a paint matrix evaluated, whilst still deterring macrofouling, including barnacles and bryozoans. Copper (I) oxide was added to a generic AF paint in 0, 8.5, 11.7 or 16.3 wt% copper oxide in combination with 0, 10 or 20 wt% zinc oxide and applied on PMMA panels. The results show that zinc influences the release rate of copper. When 10 and 20 wt% zinc was added, the total amount of copper released significantly increased by on average 32 and 47% respectively. All treatments that included copper were successful in deterring macrofouling, including the treatment with the lowest average Cu release rate, ie 4.68 μg cm−2 day−1. 

  • 9.
    Lundgren, Anders
    et al.
    Chalmers University of Technology, Sweden.
    Munktell, Sara
    Uppsala University, Sweden.
    Lacey, Matthew
    Chalmers University of Technology, Sweden.
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik. University of Gothenburg, Sweden.
    Björefors, Fredrik
    Chalmers University of Technology, Sweden.
    Formation of gold nanoparticle size and density gradients via bipolar electrochemistry2016Ingår i: ChemElectroChem, ISSN 2196-0216, Vol. 3, nr 3, s. 378-382Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Bipolar electrochemistry is employed to demonstrate the formation of gold nanoparticle size gradients on planar surfaces. By controlling the electric field in a HAuCl4-containing electrolyte, gold was reduced onto 10nm diameter particles immobilized on pre-modified thiolated bipolar electrode (BPE) templates, resulting in larger particles towards the more cathodic direction. As the gold deposition was the dominating cathodic reaction, the increased size of the nanoparticles also reflected the current distribution on the bipolar electrode. The size gradients were also combined with a second gradient-forming technique to establish nanoparticle surfaces with orthogonal size and density gradients, resulting in a wide range of combinations of small/large and few/many particles on a single bipolar electrode. Such surfaces are valuable in, for example, cell-material interaction and combinatorial studies, where a large number of conditions are probed simultaneously.

  • 10.
    Pansch, Christian
    et al.
    GEOMAR Helmholtz Centre for Ocean Research Kiel, Germany; University of Gothenburg, Sweden.
    Jonsson, Per R.
    University of Gothenburg, Sweden.
    Berglin, Mattias
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
    Pinori, Emiliano
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
    Wrange, Anna-Lisa
    RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
    A new flow-through bioassay for testing low-emission antifouling coatings2017Ingår i: Biofouling (Print), ISSN 0892-7014, E-ISSN 1029-2454, Vol. 33, nr 8, s. 613-623Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Current antifouling (AF) technologies are based on the continuous release of biocides into the water, and consequently discharge into the environment. Major efforts to develop more environmentally friendly coatings require efficient testing in laboratory assays, followed by field studies. Barnacles are important fouling organisms worldwide, increasing hydrodynamic drag on ships and damaging coatings on underwater surfaces, and thus are extensively used as models in AF research, mostly in static, laboratory-based systems. Reliable flow-through test assays for the screening of biocide-containing AF paints, however, are rare. Herein, a flow-through bioassay was developed to screen for diverse low-release biocide paints, and to evaluate their effects on pre- and post-settlement traits in barnacles. The assay distinguishes between the effects from direct surface contact and bulk-water effects, which are crucial when developing low-emission AF coatings. This flow-through bioassay adds a new tool for rapid laboratory-based first-stage screening of candidate compounds and novel AF formulations.

  • 11.
    Pinori, Emiliano
    et al.
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    The impact of coating hardness on the anti-barnacle efficacy of an embedded antifouling biocide2013Ingår i: Biofouling (Print), ISSN 0892-7014, E-ISSN 1029-2454, Vol. 29, nr 7, s. 763-773Artikel i tidskrift (Refereegranskat)
  • 12. Trepos, R
    et al.
    Pinori, Emiliano
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Jonsson, P R
    Berglin, Mattias
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Svenson, Johan
    RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Coutinho, R
    Innovative approaches for the development of new copper-free marine antifouling paints2014Ingår i: Journal of Ship and Ocean Technology, ISSN 1226-5594, Vol. 9, nr 4, s. 7-18Artikel i tidskrift (Refereegranskat)
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