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  • 1.
    Berglin, Mattias
    et al.
    RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology. University of Gothenburg, Sweden.
    Cavanagh, Jorunn Pauline
    Amicoat A/S, Norway; UiT The Arctic University of Norway, Norway.
    Caous, Josefin Seth
    RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.
    Thakkar, Balmukund Sureshkumar
    Amicoat A/S, Norway.
    Vasquez, Jeddah Marie
    RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.
    Stensen, Wenche
    UiT The Arctic University of Norway, Norway.
    Lyvén, Benny
    RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.
    Svendsen, John-Sigurd
    Amicoat A/S, Norway; UiT The Arctic University of Norway, Norway.
    Svenson, Johan
    RISE Research Institutes of Sweden, Materials and Production.
    Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions2024In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 4, article id 2300425Article in journal (Refereed)
    Abstract [en]

    Efficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing different polyolic polytetrahydrofurans, isocyanates, and chain extenders, a robust and flexible material comparable to commercial thermoplastic polyurethane is prepared. A series of short synthetic antimicrobial peptides are designed, synthesized, and covalently attached in a single coupling step to generate a homogenous coating. The lead material is shown to be biocompatible and does not display any toxicity against either mouse fibroblasts or reconstructed human epidermis according to ISO and OECD guidelines. The repelling performance of the peptide-coated materials is illustrated against colonization and biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis on coated plastic films and finally, on coated commercial central venous catheters employing LIVE/DEAD staining, confocal laser scanning microscopy, and bacterial counts. This study presents the successful development of a versatile and scalable polyurethane with the potential for use in the medical field to reduce the impact of bacterial biofilms. 

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  • 2.
    Granskog, Viktor
    et al.
    KTH Royal Institute of Technology, Sweden.
    García-Gallego, Sandra
    KTH Royal Institute of Technology, Sweden.
    von Kieseritzky, Johanna
    Karolinska Institutet, Sweden.
    Rosendahl, Jennifer
    RISE - Research Institutes of Sweden (2017-2019), Bioscience and Materials, Chemistry and Materials.
    Stenlund, Patrik
    RISE - Research Institutes of Sweden (2017-2019), Bioscience and Materials, Chemistry and Materials.
    Zhang, Yuning
    KTH Royal Institute of Technology, Sweden.
    Petronis, Sarunas
    RISE - Research Institutes of Sweden (2017-2019), Bioscience and Materials, Chemistry and Materials.
    Lyvén, Benny
    RISE - Research Institutes of Sweden (2017-2019), Bioscience and Materials, Chemistry and Materials.
    Arner, Marianne
    Karolinska Institutet, Sweden.
    Håkansson, Joakim
    RISE - Research Institutes of Sweden (2017-2019), Bioscience and Materials, Chemistry and Materials.
    Malkoch, Michael
    KTH Royal Institute of Technology, Sweden.
    High-Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair2018In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 28, no 26, article id 1800372Article in journal (Refereed)
    Abstract [en]

    The use of adhesives for fracture fixation can revolutionize the surgical procedures toward more personalized bone repairs. However, there are still no commercially available adhesive solutions mainly due to the lack of biocompatibility, poor adhesive strength, or inadequate fixation protocols. Here, a surgically realizable adhesive system capitalizing on visible light thiol–ene coupling chemistry is presented. The adhesives are carefully designed and formulated from a novel class of chemical constituents influenced by dental resin composites and self-etch primers. Validation of the adhesive strength is conducted on wet bone substrates and accomplished via fiber-reinforced adhesive patch (FRAP) methodology. The results unravel, for the first time, on the promise of a thiol–ene adhesive with an unprecedented shear bond strength of 9.0 MPa and that surpasses, by 55%, the commercially available acrylate dental adhesive system Clearfil SE Bond of 5.8 MPa. Preclinical validation of FRAPs on rat femur fracture models details good adhesion to the bone throughout the healing process, and are found biocompatible not giving rise to any inflammatory response. Remarkably, the FRAPs are found to withstand loads up to 70 N for 1000 cycles on porcine metacarpal fractures outperforming clinically used K-wires and match metal plates and screw implants.

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  • 3.
    Lyvén, Benny
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Oorganisk kemi (Kmoo).
    Mobility and methylation of mercury in forest soils2001In: Water Air and Soil Pollution: Focus 1, p. 285-393Article in journal (Other academic)
  • 4.
    Lyvén, Benny
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Oorganisk kemi (Kmoo).
    Particle size distributions of clay-rich sediments and pure cly minerals: A comparison of grain size analysis with sedimentation field-flow fractionation2001In: Aquatic geochemistry, ISSN 1380-6165, E-ISSN 1573-1421, Vol. 7, no 2, p. 155-171Article in journal (Other academic)
  • 5.
    Lyvén, Benny
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Oorganisk kemi (Kmoo).
    Haraldsson, Conny
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Oorganisk kemi (Kmoo).
    Competition between iron- and carbon-based colloidal carriers for trace metals in a freshwater assessed using flow field-flow fractionation coupled to ICPMS2003In: Geochimica et Cosmochimica Acta, Vol. 67, p. 3791-3802Article in journal (Refereed)
    Abstract [en]

    Competition between iron- and carbon-based colloidal carriers for trace metals in a freshwater assessed using flow field-flow fractionation coupled to ICPMS

  • 6.
    Lyvén, Benny
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Oorganisk kemi (Kmoo).
    Haraldsson, Conny
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Oorganisk kemi (Kmoo).
    Hassellöv, M
    Determination of continuous size and trace element distribution of colloidal material in natural water by online coupling of flow field-flow fractionation with ICP MS1999In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 71, no 16, p. 3497-3502Article in journal (Other academic)
  • 7.
    Möller, Kenneth
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Lyvén, Benny
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Oorganisk kemi (Kmoo).
    Chemical and topographical analyses of tooth surfaces after Carisolv treatment2002In: Journal of Dentistry, ISSN 0300-5712, E-ISSN 1879-176X, Vol. 30, no 2, p. 67-75Article in journal (Other academic)
  • 8.
    Svensson, Sara
    et al.
    BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
    Suska, Felicia
    BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
    Emanuelsson, Lena
    BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
    Palmquist, Anders
    BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
    Norlindh, Birgitta
    BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
    Trobos, Margarita
    BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
    Bäckros, Helen
    BIOMATCELL, Sweden; Bactiguard AB, Sweden.
    Persson, Linda
    BIOMATCELL, Sweden; Bactiguard AB, Sweden.
    Rydja, Gunilla I.
    BIOMATCELL, Sweden; Bactiguard AB, Sweden.
    Ohrlander, Mattias
    BIOMATCELL, Sweden; Bactiguard AB, Sweden.
    Lyvén, Benny
    RISE, SP – Sveriges Tekniska Forskningsinstitut. BIOMATCELL, Sweden.
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf).
    Thomsen, Peter
    BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
    Osseointegration of titanium with an antimicrobial nanostructured noble metal coating2013In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 9, no 7, p. 1048-1056Article in journal (Refereed)
    Abstract [en]

    Nanometer scale surface features on implants and prostheses can potentially be used to enhance osseointegration and may also add further functionalities, such as infection resistance, to the implant. In this study, a nanostructured noble metal coating consisting of palladium, gold and silver, never previously used in bone applications, was applied to machined titanium screws to evaluate osseointegration after 6 and 12. weeks in rabbit tibiae and femurs. Infection resistance was confirmed by in vitro adhesion test. A qualitatively and quantitatively similar in vivo bone response was observed for the coated and uncoated control screws, using histology, histomorphometry and electron microscopy. The bone-implant interface analysis revealed an extensive bone formation and direct bone-implant contact. These results demonstrate that the nanostructured noble metal coating with antimicrobial properties promotes osseointegration and may therefore be used to add extra implant functionality in the form of increased resistance to infection without the use of antibiotics. From the Clinical Editor: The authors of this paper demonstrate that nanostructured noble metal coating of implants and prostheses used in orthopedic procedures promotes osseointegration and may be used to add extra implant functionality in the form of increased resistance to infection without the use of antibiotics.

1 - 8 of 8
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