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  • 1.
    Afshari, Alireza
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor. Chalmers tekniska högskola, Institutionen för installationsteknik.
    Determination of VOC emissions from surface coatings by environmental test chamber measurements1999Doctoral thesis, monograph (Other academic)
  • 2.
    Ahniyaz, Anwar
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Precise control over shape and size of iron oxide nanocrystals suitable for assembly into ordered particle arrays2014In: Science and Technology of Advanced Materials, ISSN 1468-6996, E-ISSN 1878-5514, Vol. 15, no 5, p. 55010-Article in journal (Refereed)
  • 3.
    Albinson, B
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Ström, S
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Analys av UV-absorber i billacker med UV-VIS-spektroskopi1995Report (Refereed)
  • 4.
    Alfredsson, Robert
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Jarl, Marie-Louice
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Bestämning av sammansättning hos PVC-produkter från gamla hus.1999Report (Refereed)
  • 5. Alriksson, Björn
    et al.
    Eskilsson, Martin
    Johansson, Emma
    Lapidot, Shaul
    Norström, Markus
    Schultz-Eklund, Ola
    Shkedi, Yoram
    Svedberg, Anna
    Svensson, Stefan
    Swerin, Agne
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Europe’s first pilot facility for cellulose nanocrystals (CNC)2016In: Annual Surface and Materials Chemistry Symposium and Materials for tomorrow, ASMCS 2016, November 8-10, 2016, Gothenburg, Sweden, 2016Conference paper (Refereed)
  • 6.
    Andersson, Bo-Lennart
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Klassificering av atmosfärisk korrosivitet med hjälp av referenskuponger av olika metaller. Rekommenderade rutiner.1999Report (Refereed)
  • 7.
    Andersson, Bo-Lennart
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Carlsson, Bo
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Insamling av miljödata vid Statens Provningsanstalt i Borås.1989Report (Refereed)
  • 8.
    Andersson, Bo-Lennart
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Carlsson, Bo
    Korrosionsskyddsklassning av oorganiska ytbeläggningar: delrapport NORDTEST projekt 1459-991999Report (Refereed)
  • 9.
    Andersson, Bo-Lennart
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Carlsson, Bo
    Korrosionsskyddsklassning av organiska ytbeläggningar2000Report (Refereed)
  • 10. Andersson, J
    et al.
    Stenhamre, H
    Bäckdahl, Henrik
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Gatenholm, P
    Behaviour of human chondrocytes in engineered porous bacterial cellulose scaffolds. J Biomed Mater Res: Part A. 94A2010In: J Biomed Mater Res: Part A., Vol. 94A, no 4, p. 1124-1132Article in journal (Refereed)
  • 11. Andon, F T
    et al.
    Kapralov, A A
    Yanamala, N
    Feng, W
    Baygan, A
    Chambers, B J
    Brandner, B. D.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase2013In: Small, ISSN 1613-6810, E-ISSN 1613-6829, Vol. 9, no 16, p. 2721-2729Article in journal (Refereed)
    Abstract [en]

    Eosinophil peroxidase (EPO) is one of the major oxidant-producing enzymes during inflammatory states in the human lung. The degradation of single-walled carbon nanotubes (SWCNTs) upon incubation with human EPO and H2O 2 is reported. Biodegradation of SWCNTs is higher in the presence of NaBr, but neither EPO alone nor H2O2 alone caused the degradation of nanotubes. Molecular modeling reveals two binding sites for SWCNTs on EPO, one located at the proximal side (same side as the catalytic site) and the other on the distal side of EPO. The oxidized groups on SWCNTs in both cases are stabilized by electrostatic interactions with positively charged residues. Biodegradation of SWCNTs can also be executed in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. Biodegradation is proven by a range of methods including transmission electron microscopy, UV-visible-NIR spectroscopy, Raman spectroscopy, and confocal Raman imaging. Thus, human EPO (in vitro) and ex vivo activated eosinophils mediate biodegradation of SWCNTs: an observation that is relevant to pulmonary responses to these materials. Human eosinophil peroxidase (EPO) is able to degrade SWCNTs in vitro in the presence of H2O2. EPO is one of the major oxidant-generating enzymes present in human lungs during inflammatory states. The biodegradation of SWCNTs is evidenced also in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. These results are relevant to potential respiratory exposure to carbon nanotubes.

  • 12.
    Antonsson, Margareta
    et al.
    SP – Sveriges Provnings- och Forskningsinstitut.
    Nilsson, Karin
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Förslag till miljöledningssystem enligt ISO 14001 på del av verksamheten vid sektionen för polymerteknik1996Report (Refereed)
  • 13.
    Antonsson, Ulf
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    History, presentation and statistics of SP-method 1737 and SP-method 17382000Report (Refereed)
  • 14.
    Antonsson, Ulf
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Provning av vattentäthet hos anslutning mellan golvbrunn och tätskikt i keramiska golvbeläggningar1998Report (Refereed)
  • 15.
    Antonsson, Ulf
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Rörelser hos fogar på flygplatser1995Report (Refereed)
  • 16.
    Antonsson, Ulf
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Jakobowicz, I
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Rapport från besiktningar utförda under februari till april 1997 av fogningar på vägar och flygfält1997Report (Refereed)
  • 17.
    Antonsson, Ulf
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Jakubowicz, Ignacy
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Rapport från besiktningar utförda under januari - maj 1996 av fogningar på vägar och flygfält1996Report (Refereed)
  • 18.
    Antonsson, Ulf
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Jakubowicz, Ignacy
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Rapport från besiktningar utförda under våren 1995 av fogningar på vägar och flygfält1995Report (Refereed)
  • 19.
    Arlotto, Sébastien
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Characterisation and accelerated ageing of PVC materials from old buildings.1999Report (Refereed)
  • 20.
    Aronsson, B-O
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Lausmaa, J
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Kasemo, B
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Glow-discharge plasma treatment for surface cleaning and modificaiton of metallic biomaterials.1997In: Journal of Biomedical Materials Research, ISSN 0021-9304, E-ISSN 1097-4636, Vol. 35, no 1, p. 49-73Article in journal (Other academic)
  • 21.
    Arrhenius, Karine
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Kemi.
    Brown, A. S.
    van der Veen, A. M. H.
    Suitability of different containers for the sampling and storage of biogas and biomethane for the determination of the trace-level impurities - A review2016In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 902, p. 22-32Article, review/survey (Refereed)
    Abstract [en]

    The traceable and accurate measurement of biogas impurities is essential in order to robustly assess compliance with the specifications for biomethane being developed by CEN/TC408. An essential part of any procedure aiming to determinate the content of impurities is the sampling and the transfer of the sample to the laboratory. Key issues are the suitability of the sample container and minimising the losses of impurities during the sampling and analysis process. In this paper, we review the state-of-the-art in biogas sampling with the focus on trace impurities. Most of the vessel suitability studies reviewed focused on raw biogas. Many parameters need to be studied when assessing the suitability of vessels for sampling and storage, among them, permeation through the walls, leaks through the valves or physical leaks, sorption losses and adsorption effects to the vessel walls, chemical reactions and the expected initial concentration level. The majority of these studies looked at siloxanes, for which sampling bags, canisters, impingers and sorbents have been reported to be fit-for-purpose in most cases, albeit with some limitations. We conclude that the optimum method requires a combination of different vessels to cover the wide range of impurities commonly found in biogas, which have a wide range of boiling points, polarities, water solubilities, and reactivities. The effects from all the parts of the sampling line must be considered and precautions must be undertaken to minimize these effects. More practical suitability tests, preferably using traceable reference gas mixtures, are needed to understand the influence of the containers and the sampling line on sample properties and to reduce the uncertainty of the measurement.

  • 22.
    Arrhenius, Karine
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Organisk kemi (Kmo).
    Kühnemuth, Daniel
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Kemi.
    Traceable reference gas mixtures for sulfur-free natural gas odorants2014In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 13, no 1, p. 6695-6702Article in journal (Refereed)
  • 23.
    Arrhenius, Karine
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Podien, Doris
    Yaghooby, Haleh
    Smajovic, Nijaz
    Optimization of an Analytical Method for theMeasurement of Oil Carryover from a Compressor in Compressed Natural GasRefueling Stations2015In: Energy and Fuels, Vol. 29, no 4, p. 2416-2421Article in journal (Other academic)
    Abstract [en]

    The aims of the study were to determine the best method for extracting oil absorbed on coalescing filters at compressed natural gas (CNG) refueling stations and to compare the mass spectrometer (MS) and flame ionization detector (FID) for the quantification of the oil recovered in the extracts. Dichloromethane and heptane as solvents gave slightly higher recovery yields than pentane. The preferred extraction method with regard to time and solvent consumption consisted of an ultrasonic extraction, followed by removal of the remaining solvent under a stream of nitrogen. The FID and MS were found to be equally suitable for quantifying oil carryover, if the sample only contained the target oil when the instruments of analysis have been properly calibrated. If the sample is contaminated by compounds other than the target oil, MS and FID will provide different valuable information: MS may give information on the structure of the contaminants, while FID will give a more reliable quantification without proper calibration. The work discusses issues with the reusability of the filters and how to handle the memory effects

  • 24.
    Arrhenius, Karine
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP – Sveriges Tekniska Forskningsinstitut / Organisk kemi (Kmo).
    Yaghooby, Haleh
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Kemi.
    Smajovic, Nijaz
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Kemi.
    Optimization of an analytical method for the measurement of oil carryover from a compressor in compressed natural gas refueling stations2015In: Energy & Fuels, ISSN 0887-0624, E-ISSN 1520-5029, Vol. 29, no 4, p. 2416-2421Article in journal (Refereed)
  • 25.
    Arvidson, Magnus
    et al.
    Brandteknik, skydd (BRs ).
    Bäckman, Anna
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Hedlund, Hans-Peter
    Källqvist, Sofia
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Påverkan av vatten från sprinkler på vägg- och takmålningar2007Report (Refereed)
  • 26.
    Arvidson, Magnus
    et al.
    Brandteknik, skydd (BRs ).
    Månsson, Margret
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Utvärdering av olika frysskyddsmedel för sprinklersystem. Brandforsk projekt 631-9611999Report (Refereed)
  • 27.
    Badal Tejedor, Maria
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Nordgren, Niklas
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Schuleit, M
    Rutland, Mark W.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Millqvist-Fureby, Anna
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Tablet mechanics depend on nano and micro scale adhesion, lubrication and structure2015In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 486, no 1-2, p. 315-323Article in journal (Refereed)
    Abstract [en]

    Tablets are the most convenient form for drug administration. However, despite the ease of manufacturing problems such as powder adhesion occur during the production process. This study presents surface and structural characterization of tablets formulated with commonly used excipients (microcrystalline cellulose (MCC), lactose, mannitol, magnesium (Mg) stearate) pressed under different compaction conditions. Tablet surface analyses were performed with scanning electron microscopy (SEM), profilometry and atomic force microscopy (AFM). The mechanical properties of the tablets were evaluated with a tablet hardness test. Local adhesion detected by AFM decreased when Mg stearate was present in the formulation. Moreover, the tablet strength of plastically deformable excipients such as MCC was significantly decreased after addition of Mg stearate. Combined these facts indicate that Mg stearate affects the particle-particle bonding and thus elastic recovery. The MCC excipient also displayed the highest hardness which is characteristic for a highly cohesive material. This is discussed in the view of the relatively high adhesion found between MCC and a hydrophilic probe at the nanoscale using AFM. In contrast, the tablet strength of brittle materials like lactose and mannitol is unaffected by Mg stearate. Thus fracture occurs within the excipient particles and not at particle boundaries, creating new surfaces not previously exposed to Mg stearate. Such uncoated surfaces may well promote adhesive interactions with tools during manufacture.

  • 28.
    Benjamins, Jan-Willem
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Mechanisms behind the Stabilizing Action of Cellulose Nanofibrils in Wet-Stable Cellulose Foams2015In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 16, no 3, p. 822-831Article in journal (Refereed)
  • 29.
    Berggren, Carina
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Markinger, Monica
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Spricktillväxt i styv PVC.1989Report (Refereed)
  • 30.
    Berglin, Mattias
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Gold-nanoparticle-assisted self-assembly of chemical gradients with tunable sub-50 nm molecular domains2014In: Particle & particle systems characterization, ISSN 0934-0866, E-ISSN 1521-4117, Vol. 31, no 2, p. 209-218Article in journal (Refereed)
  • 31.
    Berglin, Mattias
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Gradients in surface nanotopography used to study platelet adhesion and activation2013In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 110, no 1, p. 261-269Article in journal (Refereed)
  • 32.
    Berglin, Mattias
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Pellet formation of zygomycetes and immobilization of yeast2013In: New Biotechnology, ISSN 1871-6784, E-ISSN 1876-4347, Vol. 30, no 5, p. 516-522Article in journal (Refereed)
  • 33. Besharat, Z.
    et al.
    Wakeham, D.
    Johnson, C. M.
    Luengo, G. S.
    Greaves, A.
    Odnevall Wallinder, I.
    Göthelid, M.
    Rutland, Mark W.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science. Department of Surface and Corrosion Science, School of Chemical Science and Engineering, KTH Royal Institute of Technology.
    Mixed monolayers of alkane thiols with polar terminal group on gold: Investigation of structure dependent surface properties2016In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 484, p. 279-290Article in journal (Refereed)
    Abstract [en]

    Adsorption of thiols with cationic or anionic terminal group on gold has been studied from mixed solutions of 11-Amino-1-undecanethiol (AUT) and 3-Mercaptopropionic acid (MPA) using Quartz Crystal Microbalance with Dissipation (QCM-D), X-ray Photoelectron Spectroscopy (XPS), atomic force microscopy (AFM) and contact angles. The goal is to probe the nature of such layers, and the additivity or otherwise of the pH responsiveness, with a view to evaluate their suitability as smart materials. For each of the two pure (unmixed) cases, ordered molecular monolayers are formed with sulfur binding to gold and the alkane chain pointing out from the surface as expected. Adsorption from the thiol mixtures, however, leads to a more complex behaviour. The surface concentration of thiols from the mixtures, as determined by QCM-D, is considerably lower than for the pure cases and it reaches a minimum at a 3:1 MPA/AUT relative concentration in the solution. The XPS results confirm a reduction in adsorbed amount in mixtures with the lowest overall intensity for the 3:1 ratio. Monolayers formed from mixtures display a wettability which is much lower and less pH sensitive. Collectively these results confirm that for adsorption from mixed systems, the configuration is completely different. Complex formation in the mixed solutions leads to the adsorption of molecules parallel to the surface in an axially in-plane configuration. This parallel layer of thiols is mechanically relatively robust to nano-shaving based on AFM measurements. These results will have a significant impact on the design of biomimetic surface coatings particularly when mixtures of oppositely charged molecules are present on the surface, as is commonly the case in biological, proteinaceous surfaces (e.g. hair and skin).

  • 34. Bhattacharya, K
    et al.
    El-Sayed, R
    Andón, FT
    Mukherjee, SP
    Gregory, J
    Li, H
    Fornara, A
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant2015In: Carbon, ISSN 0008-6223, E-ISSN 1873-3891, Vol. 91, p. 506-517Article in journal (Refereed)
    Abstract [en]

    Carbon nanotubes (CNTs) may elicit inflammatory responses following pulmonary exposure. Conversely, enzymatic biodegradation of CNTs by inflammatory cells has also been reported. The aim of this study was to study the degradation of oxidized single-walled CNTs (ox-SWCNTs) by lactoperoxidase (LPO), a secreted peroxidase present in the airways, and whether pulmonary surfactant affects this biodegradation. To this end, ox-SWCNTs were incubated in vitro with recombinant bovine LPO + H2O2 + NaSCN in the presence and absence of porcine lung surfactant (Curosurf®) and biodegradation was monitored using UV-Vis-NIR spectroscopy, Raman spectroscopy, and scanning electron microscopy. The interaction of recombinant LPO with bundles of ox-SWCNTs was confirmed by atomic force microscopy. Cell-free biodegradation of ox-SWCNTs was also observed ex vivo in murine bronchoalveolar lavage fluid in the presence of H2O2 + NaSCN. Our study provides evidence for biodegradation of ox-SWCNTs with a lung surfactant 'bio-corona' and expands the repertoire of mammalian peroxidases capable of biodegradation of ox-SWCNTs. These findings are relevant to inhalation exposure to these materials, as LPO serves as an important component of the airway defense system.

  • 35.
    Björkegren, Helena
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Bylander, Marianne
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Löwendahl, Reidun
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Interlaboratory testing of seam slippage1990Report (Refereed)
  • 36.
    Björkegren, Helena
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Bylander, Marianne
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Löwendahl, Reidun
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Sömskridning1990Report (Refereed)
  • 37.
    Björn, Camilla
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. University of Gothenburg, Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine.
    Antimicrobial peptides in the treatment of infectious and inflammatory conditions: Preclinical studies of mechanism of action, efficacy, and safety2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious diseases. AMPs are present in all living species and constitute an important part of the innate immune system in multicellular organisms, including humans. AMPs display a remarkably broad spectrum of antimicrobial activity covering both Gram-positive and Gram-negative bacteria, including many antibiotic-resistant strains, as well as fungi, viruses, and protozoa. Further, in contrast to many conventional antibiotics, AMPs rapidly kill bacteria instead of just inhibiting bacterial growth. In addition, AMPs act as modulators of the innate immune system and, importantly, bacteria seem less efficient in developing resistance towards AMPs than towards conventional antibiotics. Together these properties make AMPs highly attractive as a new class of antimicrobials, with clinical potential also extending to diseases where inflammation is part of the pathology. The aim of this thesis was to study novel AMPs with respect to their mechanism of action (MOA), antimicrobial spectrum, propensity to select for resistance, and in vivo efficacy and safety. To achieve this, we used a number of in vitro and in vivo assays, together generating a comprehensive preclinical evaluation of the peptides. The hypothesis was that the AMPs in this thesis have potential to be developed as therapeutic agents for several infectious and inflammatory conditions, including treatment of skin and soft tissue infections and prevention of postsurgical adhesion formation. The results showed that all AMPs tested (i.e. PXL03, PXL150, HLR1r, and five variants of CEN1 HC-Br) had broad antimicrobial spectra in vitro with varying sensitivity to salt and serum. Furthermore, PXL150 caused a rapid permeabilization of bacterial membrane in vitro, indicating that this is at least one part of the MOA of this peptide. Under selection pressure in vitro, bacteria did not develop resistance to the peptides tested, i.e. PXL150 and CEN1 HC. Interestingly, all peptides showed anti-inflammatory activity by inhibiting the secretion of proinflammatory mediators from stimulated human cell lines. In addition, PXL01, PXL150, and HLR1r demonstrated fibrinolytic ability in vitro by suppressing the release of plasminogen activator inhibitor-1 (PAI-1). In ex vivo and in vivo skin/wound infection models, the peptides reduced the number of viable bacteria and yeast cells. Further, PXL01 decreased postsurgical adhesion formation in vivo. Notably, nonclinical safety studies showed that PXL150 was safe and well tolerated. In conclusion, several of the peptides evaluated in this thesis demonstrated a promising preclinical efficacy and safety profile motivating further development as drug candidates for local treatment of infectious and inflammatory conditions.

  • 38.
    Björn, Camilla
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Mahlapuu, M.
    Mattsby-Baltzer, I.
    Håkansson, Joakim
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Anti-infective efficacy of the lactoferrin-derived antimicrobial peptide HLR1r2016In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 81, p. 21-28Article in journal (Refereed)
    Abstract [en]

    Antimicrobial peptides (AMPs) have emerged as a new class of drug candidates for the treatment of infectious diseases. Here we describe a novel AMP, HLR1r, which is structurally derived from the human milk protein lactoferrin and demonstrates a broad spectrum microbicidal action in vitro. The minimum concentration of HLR1r needed for killing ≥99% of microorganisms in vitro, was in the range of 3-50 μg/ml for common Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and for the yeast Candida albicans, when assessed in diluted brain-heart infusion medium. We found that HLR1r also possesses anti-inflammatory properties as evidenced by inhibition of tumor necrosis factor alpha (TNF-α) secretion from human monocyte-derived macrophages and by repression of interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1) secretion from human mesothelial cells, without any cytotoxic effect observed at the concentration range tested (up to 400 μg/ml). HLR1r demonstrated pronounced anti-infectious effect in in vivo experimental models of cutaneous candidiasis in mice and of excision wounds infected with MRSA in rats as well as in an ex vivo model of pig skin infected with S. aureus. In conclusion, HLR1r may constitute a new therapeutic alternative for local treatment of skin infections.

  • 39.
    Blomberg, Eva
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Adsorption of lysozyme on silver and its influence on silver release2014In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 30, no 46, p. 13877-13889Article in journal (Refereed)
  • 40.
    Blomberg, Eva
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Chemical, mechanical and antibacterial properties of silver nanocluster/silica composite coated textiles for safety systems and aerospace applications2014In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 317, no Oct, p. 131-139Article in journal (Refereed)
  • 41.
    Blomberg, Eva
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Correlation between surface physicochemical properties and the release of iron from stainless steel AISI 304 in biological media2014In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 122, no Oct, p. 216-222Article in journal (Refereed)
  • 42.
    Blomberg, Eva
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Effect of laundry surfactants on surface charge and colloidal stability of silver nanoparticles2013In: Langmuir, Vol. 29, no 28, p. 8882-8891Article in journal (Refereed)
  • 43.
    Blomqvist, P
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    Månsson, M
    Fire characteristics and detailed smoke gas analyses in controlled underventilated large-scale combustion experiments.1996In: Industrial fires III, Workshop Proceedings, European commission, Risø, Denmark, 17-18 september 1996., European Commission , 1996, , p. 7-16Conference paper (Other academic)
  • 44.
    Blomqvist, Per
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SP Sveriges tekniska forskningsinstitut / Brandteknik, forskning (BRf ).
    Lindberg, Per
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Certifiering, Ledningssystemcertifiering.
    Månsson, Margret
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
    TOXFIRE - Fire characteristics and smoke gas analyses in under-ventilated large-scale combustion experments. FTIR measurements.1996Report (Refereed)
  • 45.
    Bobert, Magnus
    et al.
    Brandteknik, skydd (BRs ).
    Buren, Anneli
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Spilg, Leo
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Andersson, Petra
    Brandteknik, forskning (BRf ).
    Framtagning av underlag till komponentprovning av linjevärmedetektorer för fasadmontering2007Report (Refereed)
    Abstract [sv]

    Suggestions for how to test and verify line type heat detectors suitable for facade mounting are given. Related standards including prEN54:22 are discussed. Key words: Linjevärmedetektorer, komponentprovningar, beständighetstest, funktionstest

  • 46.
    Boge, Lukas
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science. Department of Chemical and Chemical Engineering, Applied Chemistry, Chalmers University of Technology.
    Bysell, Helena
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Ringstad, Lovisa
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
    Wennman, David
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Process Development, Analys och fastfas.
    Umerska, A.
    Cassisa, V.
    Eriksson, J.
    Joly-Guillou, M. -L
    Edwards, K.
    Andersson, M.
    Lipid-based liquid crystals as carriers for antimicrobial peptides: Phase behavior and antimicrobial effect2016In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 32, no 17, p. 4217-4228Article in journal (Refereed)
    Abstract [en]

    The number of antibiotic-resistant bacteria is increasing worldwide, and the demand for novel antimicrobials is constantly growing. Antimicrobial peptides (AMPs) could be an important part of future treatment strategies of various bacterial infection diseases. However, AMPs have relatively low stability, because of proteolytic and chemical degradation. As a consequence, carrier systems protecting the AMPs are greatly needed, to achieve efficient treatments. In addition, the carrier system also must administrate the peptide in a controlled manner to match the therapeutic dose window. In this work, lyotropic liquid crystalline (LC) structures consisting of cubic glycerol monooleate/water and hexagonal glycerol monooleate/oleic acid/water have been examined as carriers for AMPs. These LC structures have the capability of solubilizing both hydrophilic and hydrophobic substances, as well as being biocompatible and biodegradable. Both bulk gels and discrete dispersed structures (i.e., cubosomes and hexosomes) have been studied. Three AMPs have been investigated with respect to phase stability of the LC structures and antimicrobial effect: AP114, DPK-060, and LL-37. Characterization of the LC structures was performed using small-angle X-ray scattering (SAXS), dynamic light scattering, ζ-potential, and cryogenic transmission electron microscopy (Cryo-TEM) and peptide loading efficacy by ultra performance liquid chromatography. The antimicrobial effect of the LCNPs was investigated in vitro using minimum inhibitory concentration (MIC) and time-kill assay. The most hydrophobic peptide (AP114) was shown to induce an increase in negative curvature of the cubic LC system. The most polar peptide (DPK-060) induced a decrease in negative curvature while LL-37 did not change the LC phase at all. The hexagonal LC phase was not affected by any of the AMPs. Moreover, cubosomes loaded with peptides AP114 and DPK-060 showed preserved antimicrobial activity, whereas particles loaded with peptide LL-37 displayed a loss in its broad-spectrum bactericidal properties. AMP-loaded hexosomes showed a reduction in antimicrobial activity.

  • 47.
    Bogestål, Yalda
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
    Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells2015In: Toxicology, ISSN 0300-483X, E-ISSN 1879-3185, Vol. 328, no Febr, p. 102-111Article in journal (Refereed)
  • 48.
    Bogren, Maria
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Linde, Maria
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Inverkan av upprepad bearbetning med mellanliggande accelererad åldring på en ostabiliserad LDPE.1993Report (Refereed)
  • 49. Bogren, S.
    et al.
    Fornara, Andrea
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
    Ludwig, F.
    Morales, M. P.
    Steinhoff, U.
    Hansen, M. F.
    Kazakova, O.
    Johansson, C.
    Classification of magnetic nanoparticle systems—synthesis, standardization and analysis methods in the nanomag project2015In: International Journal of Molecular Sciences, ISSN 1661-6596, Vol. 16, no 9, p. 20308-20325Article in journal (Refereed)
    Abstract [en]

    This study presents classification of different magnetic single- and multi-core particle systems using their measured dynamic magnetic properties together with their nanocrystal and particle sizes. The dynamic magnetic properties are measured with AC (dynamical) susceptometry and magnetorelaxometry and the size parameters are determined from electron microscopy and dynamic light scattering. Using these methods, we also show that the nanocrystal size and particle morphology determines the dynamic magnetic properties for both single- and multi-core particles. The presented results are obtained from the four year EU NMP FP7 project, NanoMag, which is focused on standardization of analysis methods for magnetic nanoparticles.

  • 50.
    Boldizar, Antal
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Polymer och fiber.
    Miljödriven företagsutveckling. En enkätundersöknng om behov av miljörelaterade tjänster bland företag i Sjuhäradsbygden1997Report (Refereed)
1234567 1 - 50 of 546
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