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  • 1. Mollmann, SH
    et al.
    Elofsson, Ulla
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Bukrinsky, JT
    Frokjaer, S
    Displacement of adsorbed insulin by Tween 80 monitored using total internal reflection fluorescence and ellipsometry2005In: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 22, p. 1931-1941Article in journal (Refereed)
    Abstract [en]

    This study was conducted to investigate the mechanism of action in the displacement of adsorbed insulin from a hydrophobic surface by Tween 80 and of the competitive adsorption of the two species. Methods Total internal reflection fluorescence (TIRF) and ellipsometry were used as in situ methods to examine the processes taking place at hydrophobic model surfaces in the presence of insulin and Tween 80. Results TIRF studies showed that the displacement of insulin by Tween 80 could be fitted to a sigmoidal function, indicating a nucleation-dependent process. Furthermore, a linear dependence between the apparent rate constant and the logarithm of the Tween 80 concentration was found. Competitive adsorption from solution mixtures of insulin and Tween 80 indicated that insulin was adsorbed first, but subsequently displaced by the surfactant. This displacement proved also to be dependent on the concentration of Tween 80 in the mixture. Conclusions The results indicate that Tween 80 at concentrations above critical micelle concentration can be used to protect insulin against surface adsorption. The presence of a lag phase in the displacement at low surfactant concentration indicates that the mechanism of action for Tween 80 to reduce adsorption of insulin may be by competing for sites at the surface.

  • 2. Mosharraf, M
    et al.
    Malmberg, M
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Fransson, J
    Formulation, lyophilization and solid-state properties of a pegylated protein2007In: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 336, p. 215-232Article in journal (Refereed)
  • 3.
    Palmkron, Shuai
    et al.
    Lunds University, Sweden.
    Gustavsson, Linnea
    RISE Research Institutes of Sweden. Lunds University, Sweden.
    Wahlgren, Marie
    Lunds University, Sweden.
    Bergensthål, Björn
    Lunds University, Sweden.
    Millqvist-Fureby, Anna
    RISE Research Institutes of Sweden, Bioeconomy and Health, Chemical Process and Pharmaceutical Development.
    Temperature and Heat Transfer Control During Freeze Drying. Effect of Vial Holders and Influence of Pressure2022In: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 39, p. 2597-Article in journal (Refereed)
    Abstract [en]

    Objective: A common issue of freeze drying is the inhomogeneity between samples, both in regards to water content and structure. The purpose of this study is to address this issue, and try to understand the cause of inhomogeneity in the heat transfer and sample temperature. Methods: The temperature and the heat transfer was measured using different setups, both with and without vial holders at various positions at different shelf temperature and chamber pressures. By comparing sublimation rate measurements (water sample) with temperature equilibrium measurements with a non-evaporating liquid (oil sample), the heat transfer contribution from radiation and conduction could be separated and investigated individually. Results: The oil sample temperature increases each time the pressure is decreased; the increase is highest at lower shelf temperatures. Using vial holder reduces the deviation between the samples but have limited effect on the temperature increase. The sublimation rate for water sample is pressure dependent and samples close to the walls have a higher sublimation rate than vials in the center. The sublimation rate increases slightly when using a vial holder but the deviation between vials becomes more random. Conclusions: The heat transfer consists of conduction through rectified vapor and radiation from surrounding walls, about 65–75% of the heat is transferred by conduction and 25–35% by radiation under normal operational conditions. As the vial holder is also influenced by the radiation, the vial inside the holder is indirectly affected by the surrounding radiation. © 2022, The Author(s).

  • 4.
    Sjöström, B
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Kaplun, A
    Talmon, Y
    Cabane, B
    Structures of nanoparticles prepared from oil-in-water emulsions1995In: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 12, p. 39-48Article in journal (Refereed)
    Abstract [en]

    Nanometric particles of three mixtures of hydrophobic substances, cholesteryl esters, have been prepared by emulsification in water. These substances were dissolved in an organic solvent which was emulsified with an aqueous solution at very high shear. Droplets of very small sizes (50-100 nm) were obtained using surfactants which were combinations of lecithins and bile salts. After the emulsification was completed, the organic solvent was removed by evaporation, yielding stable suspensions of solid particles. The sizes of these particles did not follow the reduction expected from the removal of organic solvent, indicating that the particles were not dense spheres. According to cryo-transmission electron microscopy and to small angle neutron scattering (SANS) the newly prepared particles are non-aggregated. Furthermore, the results suggest that the emulsifier used in the preparation of the emulsion and the particle core composition determines the morphology of the obtained particles. a) The shape of choleateryl acetate particles stabilized by lecithin and sodium glycocholate was examined by cryo-transmission electron microscopy; and it was found that the particles were platelets with a thickness of 10-20 nm and a diameter of 100 nm. The structures of the particles were also examined by small angle neutron scattering; these results were consistent with a platelet structure. Upon storage at high concentration in water, some aggregation was observed, but the particles remained individual platelets. b) Cholesteryl acetate particles prepared with a sorbitan ester were, on the other hand, spherical according to cryo-transmission electron microscopy and SANS measurements. c) Samples prepared with lecithin as emulsifier and a lipid mixture in the core were

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