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  • 1. Lindahl, C
    et al.
    Xia, W
    Lausmaa, Jukka
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
    Borchardt, P
    Engqvist, H
    Strontium and Silicon Co-Dopes Apatite Coating: Preparation and Function as Vehicles for Ion Delivery2012In: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, E-ISSN 2158-7043, Vol. 3, no 3, p. 335-341Article in journal (Refereed)
    Abstract [en]

    New methods to improve the bone response to metallic implants are still emerging, ranging from surface modifications of the metal to coatings and drug delivery. One further development of coatings on implants is to incorporate bioactive ions in order to stimulate the bone response without the need of drug delivery. The aim of the current study is to prepare apatite coatings containing Sr and Si using a solution method, for the purpose of further optimising the bone response to metal implants. Titanium substrates were activated to induce the formation of coatings in modified PBS solutions. Soaking in PBS solutions with different concentrations of strontium and silicate at 37°C or 60°C produced coatings with different morphologies, thicknesses and compositions. Ion release experiments showed simultaneous release of Sr and Si from the coatings both in PBS and Tris-HCl. Analysis of the results using the Korsmeyer-Peppas model indicate that the release of ions from the coatings was a combination of Fickian diffusion and dissolution of the coatings. This study shows that it is possible to coat Ti substrates with modified apatite with ion release functionality and thereby increase the possibilities for a tailored bone response in vivo.

  • 2. Xia, W
    et al.
    Lindahl, C
    Persson, C
    Thomsen, P
    Lausmaa, J
    YKI – Ytkemiska institutet.
    Engqvist, H
    Changes of Surface Composition and Morphology after Incorporation of Ions into Biomimetic Apatite Coating2010In: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, E-ISSN 2158-7043, Vol. 1, no 1, p. 7-16Article in journal (Refereed)
    Abstract [en]

    Incorporating trace elements into apatite coatings may permit the combination of several pharmaceutical effects due to the different ions. In this study, strontium, silicon, and fluoride ions have been incorporated into apatite coatings through a biomineralization method, which mimics an in vitro mineralization process. The surface composition was tested with X-ray diffraction and X-ray photoelectron spectroscopy, and the surface morphology was characterized with scanning electron microscopy. Compared with pure hydroxyapatite coating, the strontium, silicon, and fluoride substi-tuted apatite coatings showed different morphologies, such as spherical, needle-like, and nano-flake-like, respectively. The crystal size of these biomimetic hydroxyapatite coatings decreased after ion substitution. The results of the analysis of surface composition showed an increased amount of the ion substitutions with an increase of ion concentrations in the soaking solution. That means the ion incorporation into the apatite structure based on the biomineralization method could not only vary the ion content but also change the morphology of the apatite coatings. Herein, the role of ion sub-stitution is considered from the point of view of materials science at the micro structural and surface chemistry levels.

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