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  • 1.
    Han, Shaobo
    et al.
    Linköping University, Sweden.
    Ul Hassan Alvi, Naveed
    RISE Research Institutes of Sweden, Digital Systems, Smart Hardware. Linköping University, Sweden.
    Granlöf, Lars
    RISE - Research Institutes of Sweden (2017-2019), Bioeconomy, Papermaking and Packaging.
    Granberg, Hjalmar
    RISE - Research Institutes of Sweden (2017-2019), Bioeconomy, Papermaking and Packaging.
    Berggren, Magnus
    Linköping University, Sweden.
    Fabiano, Simone
    Linköping University, Sweden.
    Crispin, Xavier
    Linköping University, Sweden.
    A Multiparameter Pressure–Temperature–Humidity Sensor Based on Mixed Ionic–Electronic Cellulose Aerogels2019In: Advanced Science, E-ISSN 2198-3844, article id 1802128Article in journal (Refereed)
    Abstract [en]

    Pressure (P), temperature (T), and humidity (H) are physical key parameters of great relevance for various applications such as in distributed diagnostics, robotics, electronic skins, functional clothing, and many other Internet-of-Things (IoT) solutions. Previous studies on monitoring and recording these three parameters have focused on the integration of three individual single-parameter sensors into an electronic circuit, also comprising dedicated sense amplifiers, signal processing, and communication interfaces. To limit complexity in, e.g., multifunctional IoT systems, and thus reducing the manufacturing costs of such sensing/communication outposts, it is desirable to achieve one single-sensor device that simultaneously or consecutively measures P–T–H without cross-talks in the sensing functionality. Herein, a novel organic mixed ion–electron conducting aerogel is reported, which can sense P–T–H with minimal cross-talk between the measured parameters. The exclusive read-out of the three individual parameters is performed electronically in one single device configuration and is enabled by the use of a novel strategy that combines electronic and ionic Seebeck effect along with mixed ion–electron conduction in an elastic aerogel. The findings promise for multipurpose IoT technology with reduced complexity and production costs, features that are highly anticipated in distributed diagnostics, monitoring, safety, and security applications. © 2019 The Authors.

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  • 2.
    Huss, Jessica C.
    et al.
    Max-Planck Institute of Colloids and Interfaces, Germany.
    Schoeppler, Vanesa
    Max-Planck Institute of Colloids and Interfaces, Germany; Technische Universität Dresden, Germany.
    Merritt, David J.
    Kings Park and Botanic Garden, Australia; The University of Western Australia, Australia.
    Best, Christine
    Kings Park and Botanic Garden, Australia; The University of Western Australia, Australia.
    Maire, Eric
    University of Lyon, France.
    Adrien, Jerome
    University of Lyon, France.
    Spaeker, Oliver
    Max-Planck Institute of Colloids and Interfaces, Germany.
    Janssen, Nils
    Max-Planck Institute of Colloids and Interfaces, Germany.
    Gladisch, Johannes
    RISE - Research Institutes of Sweden (2017-2019), ICT, Acreo.
    Gierlinger, Notburga
    BOKU University of Natural Resources and Life Science, Austria.
    Miller, Ben P.
    Kings Park and Botanic Garden, Australia; The University of Western Australia, Australia.
    Fratzl, Peter
    Max-Planck Institute of Colloids and Interfaces, Germany.
    Eder, Michaela
    Max-Planck Institute of Colloids and Interfaces, Germany.
    Climate-Dependent Heat-Triggered Opening Mechanism of Banksia Seed Pods2018In: Advanced Science, E-ISSN 2198-3844, Vol. 5, no 1, article id 1700572Article in journal (Refereed)
    Abstract [en]

    Heat-triggered fruit opening and delayed release of mature seeds are widespread among plants in fire-prone ecosystems. Here, the material characteristics of the seed-containing follicles of Banksia attenuata (Proteaceae), which open in response to heat frequently caused by fire, are investigated. Material analysis reveals that long-term dimensional stability and opening temperatures of follicles collected across an environmental gradient increase as habitats become drier, hotter, and more fire prone. A gradual increase in the biaxial curvature of the hygroscopic valves provides the follicles in the driest region with the highest flexural rigidity. The irreversible deformation of the valves for opening is enabled via a temperature-dependent reduction of the elastic modulus of the innermost tissue layer, which then allows releasing the stresses previously generated by shrinkage of the fiber bundles in the adjacent layer during follicle drying. These findings illustrate the level of sophistication by which this species optimizes its fruit opening mechanism over a large distribution range with varying environmental conditions, and may not only have great relevance for developing biomimetic actuators, but also for elucidating the species' capacity to cope with climatic changes.

  • 3.
    Kretschmer, M.
    et al.
    KTH Royal Institute of Technology, Sweden.
    Ceña-Diez, R.
    Technical University of Munich, Germany.
    Butnarasu, C.
    Technical University of Munich, Germany.
    Silveira, V.
    Karolinska Institute, Sweden.
    Dobryden, Illia
    RISE Research Institutes of Sweden, Bioeconomy and Health, Material and Surface Design.
    Visentin, S.
    Technical University of Munich, Germany.
    Berglund, P.
    KTH Royal Institute of Technology, Sweden.
    Sönnerborg, A.
    Technical University of Munich, Germany.
    Lieleg, O.
    KTH Royal Institute of Technology, Sweden.
    Crouzier, Thomas
    RISE Research Institutes of Sweden, Bioeconomy and Health, Material and Surface Design. KTH Royal Institute of Technology, Sweden; Karolinska Institute, Sweden.
    Yan, Hongji
    RISE Research Institutes of Sweden, Bioeconomy and Health, Material and Surface Design. KTH Royal Institute of Technology, Sweden; Karolinska Institute, Sweden.
    Synthetic Mucin Gels with Self-Healing Properties Augment Lubricity and Inhibit HIV-1 and HSV-2 Transmission2022In: Advanced Science, E-ISSN 2198-3844, Vol. 9, no 32, article id 2203898Article in journal (Refereed)
    Abstract [en]

    Mucus is a self-healing gel that lubricates the moist epithelium and provides protection against viruses by binding to viruses smaller than the gel's mesh size and removing them from the mucosal surface by active mucus turnover. As the primary nonaqueous components of mucus (≈0.2%–5%, wt/v), mucins are critical to this function because the dense arrangement of mucin glycans allows multivalence of binding. Following nature's example, bovine submaxillary mucins (BSMs) are assembled into “mucus-like” gels (5%, wt/v) by dynamic covalent crosslinking reactions. The gels exhibit transient liquefaction under high shear strain and immediate self-healing behavior. This study shows that these material properties are essential to provide lubricity. The gels efficiently reduce human immunodeficiency virus type 1 (HIV-1) and genital herpes virus type 2 (HSV-2) infectivity for various types of cells. In contrast, simple mucin solutions, which lack the structural makeup, inhibit HIV-1 significantly less and do not inhibit HSV-2. Mechanistically, the prophylaxis of HIV-1 infection by BSM gels is found to be that the gels trap HIV-1 by binding to the envelope glycoprotein gp120 and suppress cytokine production during viral exposure. Therefore, the authors believe the gels are promising for further development as personal lubricants that can limit viral transmission. © 2022 The Authors. 

  • 4.
    Li, Haipeng
    et al.
    Karolinska Institute, Sweden.
    Merkl, Padryk
    Karolinska Institute, Sweden.
    Sommertune, Jens
    RISE Research Institutes of Sweden.
    Thersleff, Thomas
    Stockholm University, Sweden.
    Sotiriou, Georgios
    Karolinska Institute, Sweden.
    SERS Hotspot Engineering by Aerosol Self-Assembly of Plasmonic Ag Nanoaggregates with Tunable Interparticle Distance2022In: Advanced Science, E-ISSN 2198-3844, Vol. 9, no 22, article id 2201133Article in journal (Refereed)
    Abstract [en]

    Surface-enhanced Raman scattering (SERS) is a powerful sensing technique. However, the employment of SERS sensors in practical applications is hindered by high fabrication costs from processes with limited scalability, poor batch-to-batch reproducibility, substrate stability, and uniformity. Here, highly scalable and reproducible flame aerosol technology is employed to rapidly self-assemble uniform SERS sensing films. Plasmonic Ag nanoparticles are deposited on substrates as nanoaggregates with fine control of their interparticle distance. The interparticle distance is tuned by adding a dielectric spacer during nanoparticle synthesis that separates the individual Ag nanoparticles within each nanoaggregate. The dielectric spacer thickness dictates the plasmonic coupling extinction of the deposited nanoaggregates and finely tunes the Raman hotspots. By systematically studying the optical and morphological properties of the developed SERS surfaces, structure–performance relationships are established and the optimal hot-spots occur for interparticle distance of 1 to 1.5 nm among the individual Ag nanoparticles, as also validated by computational modeling, are identified for the highest signal enhancement of a molecular Raman reporter. Finally, the superior stability and batch-to-batch reproducibility of the developed SERS sensors are demonstrated and their potential with a proof-of-concept practical application in food-safety diagnostics for pesticide detection on fruit surfaces is explored. © 2022 The Authors.

  • 5.
    Malti, Abdellah
    et al.
    Linköping University, Sweden.
    Edberg, Jesper
    Linköping University, Sweden.
    Granberg, Hjalmar
    RISE, Innventia.
    Ullah Khan, Zia
    Linköping University, Sweden.
    Andreasen, Jens W.
    DTU Technical University of Denmark, Denmark.
    Liu, Xianjie
    Linköping University, Sweden.
    Zhao, Dan
    Linköping University, Sweden.
    Zhang, Hao
    University of Kentucky, USA.
    Yao, Yulong
    University of Kentucky, USA.
    Brill, Joseph W.
    University of Kentucky, USA.
    Engquist, Isak
    Linköping University, Sweden.
    Fahlman, Mats
    Linköping University, Sweden.
    Wågberg, Lars
    KTH Royal Institute of Technology, Sweden.
    Crispin, Xavier
    Linköping University, Sweden.
    Berggren, Magnus
    Linköping University, Sweden.
    An organic mixed ion-electron conductor for power electronics2015In: Advanced Science, E-ISSN 2198-3844, Vol. 3, no 2, article id 1500305Article in journal (Refereed)
    Abstract [en]

    A mixed ionic–electronic conductor based on nanofibrillated cellulose composited with poly(3,4-ethylene-dioxythio­phene):­poly(styrene-sulfonate) along with high boiling point solvents is demonstrated in bulky electrochemical devices. The high electronic and ionic conductivities of the resulting nanopaper are exploited in devices which exhibit record values for the charge storage capacitance (1F) in supercapacitors and transconductance (1S) in electrochemical transistors.

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    fulltext
  • 6.
    Zhang, Heyang
    et al.
    Ghent University, Belgium.
    Bussmann, Jeroen
    Leiden University, Netherlands.
    Huhnke, Florian
    Max Planck Institute for Medical Research, Germany.
    Devoldere, Joke
    Ghent University, Belgium.
    Minnaert, An-Katrien
    Ghent University, Belgium.
    Jiskoot, Wim
    Leiden University, Netherlands.
    Serwane, Friedhelm
    Max Planck Institute for Medical Research, Germany; Ludwig-Maximilian-University Munich, Germany; Munich Cluster for Systems Neurology, Germany.
    Spatz, Joachim
    Max Planck Institute for Medical Research, Germany; University of Heidelberg, Germany.
    Röding, Magnus
    RISE Research Institutes of Sweden, Bioeconomy and Health, Agriculture and Food. Chalmers University of Technology, Sweden; University of Gothenburg, Sweden.
    De Smedt, Stefaan
    Ghent University, Belgium.
    Braeckmans, Kevin
    Ghent University, Belgium.
    Remaut, Katrien
    Ghent University, Belgium.
    Together is Better: mRNA Co-Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co-Delivery and Protein Expression on the Single Cell Level2022In: Advanced Science, E-ISSN 2198-3844, Vol. 9, no 4, article id 2102072Article in journal (Refereed)
    Abstract [en]

    Liposomes can efficiently deliver messenger RNA (mRNA) into cells. When mRNA cocktails encoding different proteins are needed, a considerable challenge is to efficiently deliver all mRNAs into the cytosol of each individual cell. In this work, two methods are explored to co-deliver varying ratiometric doses of mRNA encoding red (R) or green (G) fluorescent proteins and it is found that packaging mRNAs into the same lipoplexes (mingle-lipoplexes) is crucial to efficiently deliver multiple mRNA types into the cytosol of individual cells according to the pre-defined ratio. A mixture of lipoplexes containing only one mRNA type (single-lipoplexes), however, seem to follow the “first come – first serve” principle, resulting in a large variation of R/G uptake and expression levels for individual cells leading to ratiometric dosing only on the population level, but rarely on the single-cell level. These experimental observations are quantitatively explained by a theoretical framework based on the stochasticity of mRNA uptake in cells and endosomal escape of mingle- and single-lipoplexes, respectively. Furthermore, the findings are confirmed in 3D retinal organoids and zebrafish embryos, where mingle-lipoplexes outperformed single-lipoplexes to reliably bring both mRNA types into single cells. This benefits applications that require a strict control of protein expression in individual cells. © 2021 The Authors. 

1 - 6 of 6
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  • ieee
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  • fi-FI
  • nn-NO
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