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  • 1.
    Karlsen, Eskil
    et al.
    Amicoat AS, Norway; Arctic University of Norway, Norway.
    Stensen, Wenche
    Amicoat AS, Norway: Arctic University of Norway, Norway.
    Juskewitz, Eric
    Arctic University of Norway, Norway.
    Svenson, Johan
    RISE Research Institutes of Sweden.
    Berglin, Mattias
    RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.
    Svendsen, John Sigurd
    Amicoat AS, Norway; Arctic University of Norway, Norway.
    Anti-colonization effect of au surfaces with self-assembled molecular monolayers functionalized with antimicrobial peptides on s. Epidermidis2021In: Antibiotics, ISSN 0066-4774, E-ISSN 2079-6382, Vol. 10, no 12, article id 1516Article in journal (Refereed)
    Abstract [en]

    Medical devices with an effective anti-colonization surface are important tools for com-batting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembled polyethylene glycol monolayer with an acetylene terminus. The peptides were covalently connected to the surface through a copper-catalyzed [3 + 2] azide-acetylene coupling (CuAAC). The anti-colonization efficacy of the surfaces varied as a function of the antimicrobial activity of the peptides, and very effective surfaces could be prepared with a 6 log unit reduction in bacterial colonization. © 2021 by the authors. 

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