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  • 1.
    Håkansson, Joakim
    et al.
    RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology. University of Gothenburg, Sweden.
    Juhlin, Oskar
    University of Gothenburg, Sweden.
    Hovannisyan, Armen
    University of Gothenburg, Sweden.
    Rosendahl, Jennifer
    RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.
    Bogestål, Yalda
    RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.
    Olmarker, Kjell
    University of Gothenburg, Sweden.
    Changes in ion-channels in the dorsal root ganglion after exposure to autologous nucleus pulposus and TNF. A rat experimental study2024In: Journal of Orthopaedics, ISSN 0972-978X, E-ISSN 2589-9082, Vol. 47, p. 23-27Article in journal (Refereed)
    Abstract [en]

    Purpose: It is known that contact of nucleus pulposus with the dorsal root ganglion may induce changes in nerve conduction and pain behavior. It has also been suggested that the behavioristic changes are caused by changes in voltage-gated ion channels, which in turn have been upregulated by TNF. Such upregulations have previously been shown for NaV 1.8 and NaV 1.9. In this investigation, we expanded the number of studied ion channels after the application of nucleus pulposus or TNF. Methods: Following removal of the left L4-5 fact joint, a disc puncture was performed and the dorsal root ganglion was exposed to nucleus pulposus (n = 5) and TNF (n = 5). Operated rats without disc puncture served as sham (n = 5) and 5 non-operated (naïve) rats were included. After 24 h, the DRGs were harvested and analyzed by quantitative PCR on validated pre-spotted primer plates displaying genes for 90 voltage-gated ion channels. Results: It was evident that the changes in operated animals were separate from the naïve rats. It was also apparent that gene expression changes in rats with nucleus pulposus or TNF application showed similar trends and were also separated from sham-operated animals. Conclusion: The application of nucleus pulposus and TNF onto the DRG in rats induces comparable changes in gene expression of several ion channels. Since the changes induced by TNF and NP are similar, one might also suspect that TNF mediates the NP-induced changes. However, such a mechanism needs further investigation. © 2023 The Authors

  • 2.
    Håkansson, Joakim
    et al.
    RISE Research Institutes of Sweden, Materials and Production, Chemistry, Biomaterials and Textiles. University of Gothenburg, Sweden.
    Simsa, Robin
    VERIGRAFT AB, Sweden.
    Bogestål, Yalda
    RISE Research Institutes of Sweden, Materials and Production, Chemistry, Biomaterials and Textiles.
    Jenndahl, Lachmi
    VERIGRAFT AB, Sweden.
    Gustafsson-Hedberg, Tobias
    VERIGRAFT AB, Sweden.
    Petronis, Sarunas
    RISE Research Institutes of Sweden, Materials and Production, Chemistry, Biomaterials and Textiles.
    Strehl, Raimund
    VERIGRAFT AB, Sweden.
    Österberg, Klas
    Sahlgrenska Academy, Sweden.
    Individualized tissue-engineered veins as vascular grafts: a proof of concept study in pig.2021In: Journal of Tissue Engineering and Regenerative Medicine, ISSN 1932-6254, E-ISSN 1932-7005, Vol. 15, no 10, p. 818-Article in journal (Refereed)
    Abstract [en]

    Personalized tissue engineered vascular grafts are a promising advanced therapy medicinal product (ATMP) alternative to autologous or synthetic vascular grafts utilized in blood vessel bypass or replacement surgery. We hypothesized that an individualized tissue engineered vein (P-TEV) would make the body recognize the transplanted blood vessel as autologous, decrease the risk of rejection and thereby avoid lifelong treatment with immune suppressant medication as is standard with allogenic organ transplantation. To individualize blood vessels, we decellularized vena cava from six deceased donor pigs and tested them for cellular removal and histological integrity. A solution with peripheral blood from the recipient pigs was used for individualized reconditioning in a perfusion bioreactor for seven days prior to transplantation. To evaluate safety and functionality of the individualized vascular graft in vivo, we transplanted reconditioned porcine vena cava into six pigs and analyzed histology and patency of the graft at different time points, with three pigs at the final endpoint 4-5 weeks after surgery. Our results showed that the P-TEV was fully patent in all animals, did not induce any occlusion or stenosis formation and we did not find any signs of rejection. The P-TEV showed rapid recellularization in vivo with the luminal surface covered with endothelial cells. In summary, the results indicate that P-TEV is functional and have potential for use as clinical transplant grafts. 

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