The increasing concern about traditional hydrophobic raw materials, e.g. nonylphenol, has called for a replacement to be found from naturally occurring substances. The combination of an aromatic ring and a short and bulky hydrophobic group is almost impossible to find among common natural products. Nevertheless, sterols and other alicyclic compounds can offer a molecular structure that in some respects resembles the structure of nonylphenol. The ring structure, sometimes with several unsaturated bond, together with a branched hydrocarbon tail, appear in both sterols and rosin acids. This chapter deals with nonionic derivatives of several types of sterol compounds, and also contains a brief overview of other alicyclic compounds from nature that have been used as surfactants.