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Nano-fiber scaffold electrodes based on PEDOT for cell stimulation
Linköping University.
Karolinska Institutet.
Linköping University.
RISE, Swerea, Swerea IVF.
Show others and affiliations
2009 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 142, no 2, p. 451-456Article in journal (Refereed)
Abstract [en]

Electronically conductive and electrochemically active 3D-scaffolds based on electrospun poly(ethylene terephthalate) (PET) nano-fibers are reported. Vapour phase polymerization was employed to achieve an uniform and conformal coating of poly(3,4-ethylenedioxythiophene) doped with tosylate (PEDOT:tosylate) on the nano-fibers. The PEDOT coatings had a large impact on the wettability, turning the hydrophobic PET fibers super-hydrophilic. SH-SY5Y neuroblastoma cells were grown on the PEDOT coated fibers. The SH-SY5Y cells adhered well and showed healthy morphology. These electrically active scaffolds were used to induce Ca2+ signalling in SH-SY5Y neuroblastoma cells. PEDOT:tosylate coated nano-fibers represent a class of 3D host environments that combines excellent adhesion and proliferation for neuronal cells with the possibility to regulate their signalling. © 2009 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2009. Vol. 142, no 2, p. 451-456
Keywords [en]
Cell stimulation, Electrospinning, Nano-fibers, Poly(ethylene terephthalate) (PET), Poly(ethylenedioxythiophene) (PEDOT), SH-SY5Y neuroblastoma cells
National Category
Materials Engineering
Identifiers
URN: urn:nbn:se:ri:diva-13374DOI: 10.1016/j.snb.2009.04.062Scopus ID: 2-s2.0-71749106688OAI: oai:DiVA.org:ri-13374DiVA, id: diva2:973580
Available from: 2016-09-22 Created: 2016-09-22 Last updated: 2017-11-21Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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