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Immunogenic properties of TEMPO-treated wood nanocellulose
Institute of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway..
Institute of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway..
RISE, Innventia, PFI – Paper and Fiber Research Institute.ORCID iD: 0000-0002-6183-2017
Institute of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway.; Department of Dermatology, St. Olavs Hospital HF, Trondheim University Hospital, Trondheim, Norway.
2014 (English)Conference paper, Published paper (Refereed)
Abstract [en]

Bacterial nanocellulose (BNC) has been shown to be a good candidate in wound healing applications. However, there exists to date no cost efficient mass production of BNC. On the other side, wood nanocellulose (WNC) can be produced in large-scale and has also been suggested as a potential substrate for wound dressings. In WNC the cellulose fibers are disintegrated into individualized nanofibrils with typical diameters < 20 nm. Chemical pretreatment such as TEMPO-mediated oxidation yields a homogenous nanofibril morphology and modifies the surface chemistry of cellulose by introducing carboxyl groups and a small amount of aldehyde groups. A difference between BNC and WNC is that the last one usually consists of hemicellulose and small amounts of lignin, in addition to cellulose. Recently, we have demonstrated that WNC is not cytotoxic to 3T3-cells (mouse fibroblasts). However, to properly assess the properties of WNC for wound healing it is necessary to measure the cytotoxicity towards human skin cells, i.e. keratinocytes and fibroblasts, which is performed in this study. Additionally, using the lepirudin whole blood model the effect a material has on the activation of the complement system and the coagulation pathway can be studied. In order to use this model it is crucial to have a material which is free from bacterial composites, such as lipopolysaccharides (LPS). Importantly, we have in this work developed a new protocol for producing ultrapure nanocellulose with LPS concentration below 100 EU/g. This presentation will give an overview of recent results within the testing of the cytotoxic and immunogenic properties of WNC, which is important to verify for advanced wound healing applications.

Place, publisher, year, edition, pages
2014.
National Category
Nano Technology Biomaterials Science
Identifiers
URN: urn:nbn:se:ri:diva-9674OAI: oai:DiVA.org:ri-9674DiVA: diva2:968427
Conference
BioNanoMed Conference- Nanomaterials for Biomedical Applications, March 26 – 28, Krems, Austria.
Available from: 2016-09-12 Created: 2016-09-12 Last updated: 2016-10-26Bibliographically approved

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