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Controlling the elastic modulus of cellulose nanofibrils hydrogels by crosslinking: a premise for their use in medical applications
RISE, Innventia, PFI – Paper and Fiber Research Institute.ORCID iD: 0000-00003-2271-3637
2014 (English)Conference paper, Published paper (Refereed)
Abstract [en]

Cellulose nanofibrils can be utilized as a building block in novel material concepts. One area of particular interest is formation of hydrogels for use in medical applications such as drug delivery and tissue engineering. Compared to bacterial cellulose, which is presently used for some medical applications but is produced through a somewhat inefficient process, cellulose nanofibrils from wood can be produced effectively and in large quantities. Cellulose nanofibrils are nano-scaled fibres with high aspect ratio and strong interactions with water. In order to produce stable macroscopic structures which perform adequately in humid conditions, the nanofibrils must be cross-linked in a controlled way. Several properties are important for a successful utilization of hydrogels for biomedical applications, such as degradation, bio-adhesion, bioactivity, transport through the network and mechanical properties. In the present work focus is set on the mechanical and viscoelastic properties of hydrogels. Hydrogels of oxidized cellulose nanofibrils were formed by crosslinking the nanofibrils through the formation of covalent bonds between the crosslinking molecules and oxidized sites at the nanofibril surfaces. The elastic moduli of the hydrogels were controlled by varying the concentration and the length of the crosslinking molecules. Results from cytotoxicity studies of cellulose nanofibrils will be shown.

Place, publisher, year, edition, pages
2014.
National Category
Nano Technology Biomaterials Science
Identifiers
URN: urn:nbn:se:ri:diva-9664OAI: oai:DiVA.org:ri-9664DiVA: diva2:968417
Conference
The 6th Workshop on Cellulose, Regenerated Cellulose and Cellulose Derivatives, 11.-12. November 2014, Karlstad, Sweden.
Available from: 2016-09-12 Created: 2016-09-12 Last updated: 2016-10-26Bibliographically approved

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