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IgE cross reactivity between reindeer and bovine milk ?-lactoglobulins in cow's milk allergic patients
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2006 (English)In: Journal of investigational allergology & clinical immunology, ISSN 1018-9068, E-ISSN 1698-0808, Vol. 16, no 5, 296-302 p.Article in journal (Refereed)
Abstract [en]

Background: Allergic reactions to cow's milk are common in small children. One of the main protein allergens found in cow's milk is ?-lactoglobulin (?-Lg). Reindeer and bovine milk both contain related ?-Lg proteins, but the allergenicity of reindeer ?-Lg has not previously been studied. The purpose of this study was to analyze the immunological cross-reactivity of IgE antibodies from children with cow's milk allergy to reindeer and bovine ?-Lg. Methods: Sera from 17 children and a serum pool of 4 patients with elevated cow's milk-specific IgE were investigated. ?-Lg from bovine and reindeer milk was isolated in native form and an enzyme-linked immunosorbent inhibition assay was developed. Bovine ?-Lg was used as a capturing antigen and the inhibiting effects of reindeer and bovine ?-Lg on the IgE binding were measured. Results: Cross-reactivity patterns of bovine milk ?-Lg specific IgE to reindeer ?-Lg varied among patients. In general, reindeer ?-Lg showed significantly lower inhibition (mean 43%) of IgE binding to the capturing antigen than did bovine ?-Lg (mean 89%). In some patients, even high concentrations of reindeer ?-Lg only partly eliminated the IgE binding to bovine ?-Lg. Conclusions: The partial cross-reactivity of human anti-bovine IgE with reindeer ?-Lg suggests that it lacks important bovine epitopes and those that are recognized are only weakly bound. © 2006 Esmon Publicidad.

Place, publisher, year, edition, pages
2006. Vol. 16, no 5, 296-302 p.
Keyword [en]
Food Engineering
Keyword [sv]
Livsmedelsteknik
National Category
Food Science
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URN: urn:nbn:se:ri:diva-9001PubMedID: 17039668OAI: oai:DiVA.org:ri-9001DiVA: diva2:966875
Available from: 2016-09-08 Created: 2016-09-08Bibliographically approved

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PubMedhttp://www.scopus.com/inward/record.url?eid=2-s2.0-33750041635&partnerID=40&md5=8e4b0a5d0d5295050a72fdf809ce4fad
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SIK – Institutet för livsmedel och bioteknik
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Journal of investigational allergology & clinical immunology
Food Science

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CiteExportLink to record
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Citation style
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