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A scalable route to 5-substituted 3-isoxazolol fibrinolysis inhibitor AZD6564
Novo Nordisk A/S, Denmark.
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Process Development, Substans och formulering.ORCID iD: 0000-0002-3715-1959
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Process Development, Katalys.
Global Medicines Development, Sweden.
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2014 (English)In: Organic Process Research & Development, ISSN 1083-6160, E-ISSN 1520-586X, Vol. 18, no 8, p. 952-959Article in journal (Refereed) Published
Abstract [en]

A practical and chromatography-free multikilogram synthesis of a 3-isoxazolol containing antifibrinolytic agent, AZD6564, has been developed in eight steps and 7% overall yield starting from methyl 2-chloroisonicotinate. Highlights in the synthesis are a Negishi coupling and an enzymatic resolution of a racemic ester. 
Place, publisher, year, edition, pages
2014. Vol. 18, no 8, p. 952-959
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Natural Sciences
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URN: urn:nbn:se:ri:diva-6756DOI: 10.1021/op500193sScopus ID: 2-s2.0-84906221502Local ID: 23790OAI: oai:DiVA.org:ri-6756DiVA, id: diva2:964596
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2024-03-03Bibliographically approved

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Bollmark, Martin

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