The current paper focuses on the determination of reliable numerical models of earth block masonry wallettes under different loading conditions. Uniaxial compression and diagonal compression tests were performed. Experimental behaviour was modelled with a non-linear model able to describe the cracking behaviour. The simplified approach based on macro-modelling shows a satisfactory accuracy and low computational costs. The results reproducing the uniaxial compression are in good correspondence with the post-elastic behaviour observed in the experimental campaign. The micro-modelling approach adopted to reproduce the shear behaviour, even with high computational cost, represents a suitable tool to predict the masonry collapse mechanism.