Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Isolation, characterization, and synthesis of the Barrettides: disulfide-containing peptides from the marine sponge Geodia barretti
University of Queensland, Australia.
University of Queensland, Australia.
Uppsala University, Sweden.
Uppsala University, Sweden.
Show others and affiliations
2015 (English)In: Journal of Natural Products, ISSN 0163-3864, E-ISSN 1520-6025, Vol. 78, no 8, p. 1886-1893Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Two disulfide-containing peptides, barrettides A (1) and B (2), from the cold-water marine sponge Geodia barretti are described. Those 31 amino acid residue long peptides were sequenced using mass spectrometry methods and structurally characterized using NMR spectroscopy. The structure of 1 was confirmed by total synthesis using the solid-phase peptide synthesis approach that was developed. The two peptides were found to differ only at a single position in their sequence. The three-dimensional structure of 1 revealed that these peptides possess a unique fold consisting of a long β-hairpin structure that is cross-braced by two disulfide bonds in a ladder-like arrangement. The peptides are amphipathic in nature with the hydrophobic and charged residues clustered on separate faces of the molecule. The barrettides were found not to inhibit the growth of either Escherichia coli or Staphylococcus aureus but displayed antifouling activity against barnacle larvae (Balanus improvisus) without lethal effects in the concentrations tested. (Figure Presented).

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2015. Vol. 78, no 8, p. 1886-1893
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:ri:diva-154DOI: 10.1021/acs.jnatprod.5b00210Scopus ID: 2-s2.0-84940484024OAI: oai:DiVA.org:ri-154DiVA, id: diva2:939192
Note

Publication no: A3565

Available from: 2016-06-18 Created: 2016-06-07 Last updated: 2019-07-05Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopusLänk till open access artikeln på ACS
By organisation
Material och ytteknik
In the same journal
Journal of Natural Products
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 12 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
v. 2.35.7