Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A unified thermodynamic and kinetic approach for prediction of microcapsule morphologies
Chalmers University of Technology, Sweden.
Chalmers University of Technology, Sweden.
Chalmers University of Technology, Sweden.
Chalmers University of Technology, Sweden.
Show others and affiliations
2024 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 662, p. 572-582Article in journal (Refereed) Published
Abstract [en]

Hypothesis: Microcapsule formation, following internal phase separation by solvent evaporation, is controlled by two main factors of thermodynamic and kinetic origin. Morphology prediction has previously focused on the final thermodynamical state in terms of spreading conditions, limiting the prediction accuracy. By additionally considering kinetic effects as the emulsion droplet evolves through the two-phase region of its ternary phase diagram during solvent evaporation, this should enhance prediction accuracy and explain a wider range of morphologies. Experiments: Dynamical interfacial tensions, and thereby spreading coefficients, during the formation of poly(methyl methacrylate) and poly(D,L-lactic-co-glycolic acid) microcapsules were measured by first establishing the boundaries and tie-lines of the ternary system in the emulsion droplets. Kinetic effects during the formation were investigated by varying the solvent evaporation rate and hence the time for polymer shell formation equilibration. The theory was validated by comparing predicted morphologies to microscopic snapshots of intermediate and final morphologies. Findings: The proposed theory explained both intermediate acorn and core–shell morphologies, where a late transition from acorn to core–shell produced microcapsules containing highly off-centered cores. By considering the kinetic factors, the formulation could be altered from yielding kinetically frozen acorns to core–shell and from yielding multicore to single core microcapsules. © 2024

Place, publisher, year, edition, pages
Academic Press Inc. , 2024. Vol. 662, p. 572-582
Keywords [en]
Drops; Emulsification; Emulsions; Esters; Evaporation; Kinetic theory; Kinetics; Microstructure; Phase separation; Shells (structures); Solvents; chloroform; glycolic acid; poly(methyl methacrylate); polymer; solvent; Core shell; Internal phase separation; Kinetic effect; Microcapsules; PLGA; PMMA; Prediction accuracy; Solvent evaporation; Spreading; Thermodynamics and kinetics; Article; controlled study; emulsion; evaporation; fluorescence; fluorescence imaging; fluorescence intensity; fluorescence microscopy; kinetics; microcapsule; microencapsulation; microplastic pollution; microscopy; molecular weight; morphology; nuclear magnetic resonance spectroscopy; phase separation; prediction; proton nuclear magnetic resonance; quartz crystal microbalance; surface tension; tensiometry; thermodynamics; article; microencapsulation; Forecasting
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:ri:diva-72761DOI: 10.1016/j.jcis.2024.01.191Scopus ID: 2-s2.0-85185323243OAI: oai:DiVA.org:ri-72761DiVA, id: diva2:1857829
Note

The Swedish Research Council FORMAS (2018 − 02284) is acknowledged for funding. 

Available from: 2024-05-14 Created: 2024-05-14 Last updated: 2024-08-14Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records

Andersson Trojer, Markus

Search in DiVA

By author/editor
Andersson Trojer, Markus
By organisation
Polymer, Fiber and Composite
In the same journal
Journal of Colloid and Interface Science
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 72 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf