We numerically simulate the hydrodynamic response of a floating offshore wind turbine (FOWT) using CFD. The FOWT under consideration is a slack-moored 1:70 scale model of the UMaine VolturnUS-S semi-submersible platform. This set-up has been experimentally tested in the COAST Laboratory Ocean Basin at the University of Plymouth, UK. The test cases under consideration are (i) static equilibrium load cases, (ii) free decay tests and (iii) two focused wave cases with different wave steepness. The FOWT is modelled using a two-phase Navier-Stokes solver inside the OpenFOAM-v2006 framework. The catenary mooring is computed by dynamically solving the equations of motion for an elastic cable using the MoodyCore solver. The results of the static and decay tests are compared to the experimental values with only minor differences in motions and mooring forces. The focused wave cases are also shown to be in good agreement with measurements. The use of a one-way fluid-mooring coupling results in slightly higher mooring forces, but does not influence the motion response of the FOWT significantly.