This study explores how human-centered digitalization can contribute to the flexibility and adaptability of small and medium-sized enterprise (SME) production processes, resulting in more resilient systems. This study explains the relationship between digital technologies and production system features through progressively more human-centric stages of a digitalized manufacturing system. The authors present a case study of an SME that implemented a human-centric strategy, placing people’s needs and interests at the center of its processes, leading to more flexible and inclusive production processes and consistent with the goals of Industry 5.0. The results suggest that a digitalized working method that considers human capabilities and needs can enable a more diverse workforce and the rapid setup of new and additional production processes, thus helping SMEs respond to supply chain disruptions. The findings have implications for managers and practitioners interested in driving or supporting the transition of SMEs to human-centric, resilient, and sustainable businesses.