With material properties as a starting point, this study focuses on analyzing the performance of a paperboard package. Torsional and compressive loading of a paperboard package have been investigated through physical experiments and finite element (FE) simulations, where an orthotropic linear elastic material model with a stress-based failure criterion was used. Comparing physical experiments and FE simulations of box compression and torsion showed that the finite element models could accurately predict the response curves. Additionally, the model was utilized to investigate which impact variations in moisture, bending stiffness, and crease quality had on packaging performance. The effect of moisture was examined through an established master curve, where the necessary mechanical properties could be expressed as linear functions of moisture ratio. The impact of creases was evaluated by varying previously established ratios (relative crease strength, RCS, tensile strength, RTS) for reducing the creases’ mechanical properties in the simulations. Furthermore, the results showed that the strength of the paperboard affects the maximum compressive strength and maximum torque. Still, the bending stiffness of the paperboard only had a minor effect on box compression strength. To conclude, the model accurately predicted how moisture, crease quality, and bending stiffness affected packaging performance.