Experiments have been conducted to evaluate the containment of smoke and heat using water mist curtains in a model setup of a ro-ro ship's cargo deck with a scale of 1:13, providing practical insights into the application of such fire protection systems in the cargo deck as well as valuable data for future numerical simulations. In this regard, the requirements of the international convention of Safety of Life at Sea (SOLAS) are studied for the side openings of so-called ‘open decks’ in comparison with ‘closed decks’, especially to examine the feasibility of using water mist curtains for creating isolated subdivisions in the ro-ro space as a fire management strategy. The water mist curtains are created with one or two rows of water mist nozzles at pressures ranging from 3 to 8 bar, while the source of smoke and heat is a liquid pool fire, and inert cargo items are used in some experiments. Correspondingly, the interaction between the water mist curtain(s) and the fire is evaluated in terms of its heat release rate, and the containment effect is quantified via measurements of smoke flow through the deck and through the windows, concentrations of gaseous species, as well as gas temperatures at various key locations. The study shows that water mist curtains have a strong effect on fire dynamics and smoke propagation, but containment is dependent on the configuration of side openings and the location of fire, among other important factors.