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Taking the Green Road Towards Pharmaceutical Manufacturing
RISE Research Institutes of Sweden, Bioeconomy and Health, Chemical Process and Pharmaceutical Development.ORCID iD: 0000-0001-5781-1689
2022 (English)In: Synthesis (Stuttgart), ISSN 0039-7881, E-ISSN 1437-210X, Vol. 54, no 19, p. 4257-Article in journal (Refereed) Published
Abstract [en]

The introduction of the Green Chemistry Principles in the late 1990s formed the basis for a transition to a greener environment. These Principles have become an integral part in the work on designing chemical processes, especially for large-scale manufacture. The ultimate target is the achievement of a sustainable production method allowing hundreds of tons of valuable materials to be prepared. For this purpose, a holistic view must be applied to the elements constituting a fullyfledged process encompassing layout of the synthetic route, defining starting materials and their origin, output of product and quality features, quantity of effluent streams and waste, recovery and recycling of chemicals involved, and energy consumption. These parameters form a complex matrix where the individual components are in a complicated relationshipwith each other. This short review addresses these issues and the benefits of life-cycle assessment and metrics commonly used to measure the performance of chemical manufacturing all from a pharmaceutical industry perspective as experienced by the author. 

Place, publisher, year, edition, pages
Georg Thieme Verlag , 2022. Vol. 54, no 19, p. 4257-
Keywords [en]
catalysis, E factor, green chemistry, pharmaceutical manufacturing, PMI, process design, sustainability
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:ri:diva-59251DOI: 10.1055/a-1752-5471Scopus ID: 2-s2.0-85128486434OAI: oai:DiVA.org:ri-59251DiVA, id: diva2:1660262
Available from: 2022-05-23 Created: 2022-05-23 Last updated: 2023-10-31Bibliographically approved

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Federsel, Hans-Jürgen

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