Adsorption characterization of various modified β-cyclodextrins onto TEMPO-oxidized cellulose nanofibril membranes and cryogelsShow others and affiliations
2021 (English)In: Sustainable Chemistry and Pharmacy, E-ISSN 2352-5541, Vol. 24, article id 100523Article in journal (Refereed) Published
Abstract [en]
TEMPO-Oxidized cellulose nanofibrils (toCNF), in the form of highly entangled network such as membrane or cryogels, have proven to be of interest for various applications, including drug release or purification by pollutant adsorption. β-Cyclodextrins (β-CDs) have the ability to form inclusion complexes with large amount of hydrophobic molecules, and are considered as a promising way to bring new functionalities to these materials, by reducing drug burst release effect or improving the pollutant adsorption properties. The study of the adsorption β-CDs onto toCNF is then crucial to design toCNF/β-CDs materials, but is very complex due to the chemical proximity between these compounds. In this study, we develop toCNF cryogels containing various types of β-CDs derivatives by physical adsorption. Different protocols for analyzing the interactions between these compounds, such as Isothermal Titration Calorimetry (ITC), Quartz-Crystal Microbalance with dissipation monitoring (QCM-d) and a Phenolphthalein-based protocol (PhP protocol) have been performed. Adsorption between β-CD and toCNF was proven at two different temperatures with ITC. QCM-d measurements allowed measuring adsorption of different β-CDs derivatives onto toCNF, with higher adsorption measured for the modified β-CDs, and with estimated binding capacity ranging from 13.4 to 47.6 μmol/g toCNF. PhP protocol allowed us to monitor the amount of β-CDs released in aqueous environment, highlighting a lower release for modified β-CDs onto toCNF, and the results were consistent with the estimated binding capacity. This quantification of the binding adsorption capacity of various β-CDs is key results for optimizing the design of toCNF/β-CDs materials.
Place, publisher, year, edition, pages
Elsevier B.V. , 2021. Vol. 24, article id 100523
Keywords [en]
Adsorption, Cyclodextrin derivatives, Isothermal titration Calorimetry, Nanocellulose, Quartz-crystal microbalance, β-Cyclodextrin
National Category
Physical Chemistry
Identifiers
URN: urn:nbn:se:ri:diva-58533DOI: 10.1016/j.scp.2021.100523Scopus ID: 2-s2.0-85122786330OAI: oai:DiVA.org:ri-58533DiVA, id: diva2:1638806
Note
Funding details: Norges Teknisk-Naturvitenskapelige Universitet, NTNU; Funding details: Agence Nationale de la Recherche, ANR, ANR-15-IDEX-02; Funding details: Labex, ANR-11-LABX-0030; Funding details: Department of Chemical Engineering, Universiti Teknologi Petronas; Funding details: European Regional Development Fund, ERDF; Funding details: Institut Carnot PolyNat, ANR-16-CARN-0025-01; Funding text 1: This work is supported by the French National Research Agency in the framework of the “Investissements d'avenir” program Glyco@Alps (ANR-15-IDEX-02) and NTNU through its Department of Chemical Engineering. LGP2 is part of the LabEx Tec 21 (Investissements d’Avenir—Grant Agreement No. ANR-11-LABX-0030) and of the PolyNat Carnot Institute (Investissements d’Avenir—Grant Agreement No. ANR-16-CARN-0025-01). This research was made possible thanks to the facilities of the TekLiCell platform funded by the Région Rhône-Alpes (ERDF: European regional development fund). The authors acknowledge J. Viguié (LGP2) for discussion on absorption capacity and porosity, E. Gillon (Cermav) for lab support with ITC , Y. Navon (CTP) for access to QCM-d, C. Lancelot-Pin (Cermav) for TEM images and the Nanobio Joint Technology Platform of the Institute of Molecular Chemistry of Grenoble, A. Benard (LGP2) for the 3D cyclodextrin, M. Saulais (LGP2) for the SEM images.; Funding text 2: This work is supported by the French National Research Agency in the framework of the ?Investissements d'avenir? program Glyco@Alps (ANR-15-IDEX-02) and NTNU through its Department of Chemical Engineering. LGP2 is part of the LabEx Tec 21 (Investissements d'Avenir?Grant Agreement No. ANR-11-LABX-0030) and of the PolyNat Carnot Institute (Investissements d'Avenir?Grant Agreement No. ANR-16-CARN-0025-01). This research was made possible thanks to the facilities of the TekLiCell platform funded by the R?gion Rh?ne-Alpes (ERDF: European regional development fund). The authors acknowledge J. Vigui? (LGP2) for discussion on absorption capacity and porosity, E. Gillon (Cermav) for lab support with ITC, Y. Navon (CTP) for access to QCM-d, C. Lancelot-Pin (Cermav) for TEM images and the Nanobio Joint Technology Platform of the Institute of Molecular Chemistry of Grenoble, A. Benard (LGP2) for the 3D cyclodextrin, M. Saulais (LGP2) for the SEM images.
2022-02-172022-02-172024-08-13Bibliographically approved