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A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions
University of Gothenburg, Sweden.
University of Gothenburg, Sweden.
University of Gothenburg, Sweden.ORCID iD: 0000-0001-6783-4622
University of Gothenburg, Sweden.
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2005 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 174, no 4, p. 2235-2241Article in journal (Refereed) Published
Abstract [en]

We have identified a synthetic peptide derived from the secreted portion of HSV type 2 glycoprotein G, denoted gG-2p20, which has proinflammatory properties in vitro. The gG-2p20 peptide, corresponding to aa 190-205 of glycoprotein G-2, was a chemoattractant for both monocytes and neutrophils in a dose-dependent fashion, and also induced the release of reactive oxygen from these cells. The receptor mediating the responses was identified as the formyl peptide receptor. The gG-2p20-induced activation of phagocytes had a profound impact on NK cell functions. The reactive oxygen species produced by gG-2p20-activated phagocytes both inhibited NK cell cytotoxicity and accelerated the apoptotic cell death in NK cell-enriched lymphocyte populations. Hence, we have for the first time been able to identify a potential function of the secreted portion of HSV-2 glycoprotein G. We propose that the proinflammatory gG-2p20 peptide identified could contribute to a reduced function and viability of NK cells during HSV-2 infection due to its ability to recruit and activate phagocytic cells.

Place, publisher, year, edition, pages
American Association of Immunologists , 2005. Vol. 174, no 4, p. 2235-2241
Keywords [en]
glycoprotein g 2p20, thrombospondin, unclassified drug, virus protein, article, cellular immunity, controlled study, dose response, drug effect, drug mechanism, herpes simplex, Herpes simplex virus 2, human, human cell, inflammation, monocyte, natural killer cell, neutrophil, neutrophil chemotaxis, nonhuman, phagocytosis, priority journal, T lymphocyte activation
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-56885DOI: 10.4049/jimmunol.174.4.2235Scopus ID: 2-s2.0-13544274448OAI: oai:DiVA.org:ri-56885DiVA, id: diva2:1612570
Available from: 2021-11-18 Created: 2021-11-18 Last updated: 2024-04-12Bibliographically approved

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