Nanomaterials in the European chemicals legislation-methodological challenges for registration and environmental safety assessmentShow others and affiliations
2021 (English)In: Environmental Science: Nano, ISSN 2051-8153, Vol. 8, no 3, p. 731-747Article in journal (Refereed) Published
Abstract [en]
In the European Union the Annexes of its chemical legislation (REACH) were revised and now clarify the technical data requirements for nanomaterials (NMs). These new provisions, effective from January 1, 2020, introduce requirements for manufacturers, importers and downstream users regarding registration and safety assessment of NMs. This study aims to assess the availability and suitability of methods needed to comply with the new regulatory provisions on NMs for physico-chemical characterisation and environmental fate and effects. The scientific literature and relevant test guideline frameworks were reviewed to identify applicable methods. These were subsequently evaluated and categorised as either: 'internationally accepted test guideline or standard (TGS)', 'internationally accepted test guideline or standard under development (TGSUD)', 'established as standard methods in scientific literature (SCI)', 'other methods and/or more research needed (O)' or 'no method (N)'. We find that 80% of the information requirements and a bit more than 40% of the waiving criteria in the new REACH Annexes are supported by methods that are available as TGS, TGSUD or SCI. Most of the relevant methods in the scientific literature are included in recent OECD guidance documents or ECHA guidance. We recommend that a targeted effort is made to develop protocols and guidelines for methods to determine NM adsorption/desorption, degradation, exposure scenarios and ability to cross biological membranes. Here methods to fulfil the information requirements and waiving criteria are currently lacking. Furthermore, we recommend that increasing attention is directed towards regulatory reliability and relevance of the information that is submitted by the registrants.
Place, publisher, year, edition, pages
Royal Society of Chemistry , 2021. Vol. 8, no 3, p. 731-747
Keywords [en]
Biological membranes, Cytology, Nanostructured materials, Safety engineering, Adsorption/desorption, Environmental fate, Environmental safety, Guidance document, Information requirement, Physico-chemicals, Safety assessments, Scientific literature, Laws and legislation
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:ri:diva-52832DOI: 10.1039/d0en01123aScopus ID: 2-s2.0-85103358663OAI: oai:DiVA.org:ri-52832DiVA, id: diva2:1547430
2021-04-262021-04-262023-05-22Bibliographically approved