Silica nanoparticles (SNPs) dissolve in alkaline media, which limits their use in certain applications. Here, we report a delayed dissolution of SNPs in strong alkali induced by zinc oxide (ZnO), an additive which also limits gelation of alkaline cellulose solutions. This allows incorporating high solid content of silica (30 wt%) in cellulose solutions with retention of their predominant viscous behavior long enough (ca. 180 min) to enable fiber wet spinning. We show that without addition of ZnO, silica dissolves completely, resulting in strong gelation of cellulose solutions that become unsuitable for wet spinning. With an increase of silica concentration, gelation of the solutions occurs faster. Employing ZnO, silica-rich regenerated cellulose fibers were successfully spun, possessing uniform cross sections and smooth surface structure without defects. These findings are useful in advancing the development of functional man-made cellulose fibers with incorporated silica, e.g., fibers with flame retardant or self-cleaning properties. © 2021 The Author(s)