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Flexible Printed Organic Electrochemical Transistors for the Detection of Uric Acid in Artificial Wound Exudate
Università di Modena e Reggio Emilia, Italy.
Università di Modena e Reggio Emilia, Italy; Linköping University, Sweden.
Università di Modena e Reggio Emilia, Italy.
Università di Modena e Reggio Emilia, Italy.
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2020 (English)In: Advanced Materials Interfaces, ISSN 2196-7350, Vol. 7, no 23, article id 2001218Article in journal (Refereed) Published
Abstract [en]

Low-cost, minimally invasive sensors able to provide real-time monitoring of wound infection can enable the optimization of healthcare resources in chronic wounds management. Here, a novel printed organic electrochemical transistors (OECT) biosensor for monitoring uric acid (UA), a bacterial infection biomarker in wounds, is demonstrated in artificial wound exudate. The sensor exploits the enzymatic conversion of UA to 5-hydroxyisourate, catalyzed by Uricase entrapped in a dual-ionic-layer hydrogel membrane casted onto the gate. The sensor response is based on the catalytic oxidation of the hydrogen peroxide, generated as part of the Uricase regeneration process, at the Pt modified gate. The proposed dual membrane avoids the occurrence of nonspecific faradic reactions as, for example, the direct oxidation of UA or other electroactive molecules that would introduce a potentially false negative response. The biosensor is robust and its response is reproducible both in phosphate buffer saline and in complex solutions mimicking the wound exudate. The sensor has a high sensitivity in the range encompassing the pathological levels of UA in wounds (<200 μm) exhibiting a limit of detection of 4.5 μm in artificial wound exudate. All these characteristics make this OECT-based biosensor attractive for wound monitoring interfaced to the patient.

Place, publisher, year, edition, pages
Wiley-VCH Verlag , 2020. Vol. 7, no 23, article id 2001218
Keywords [en]
enzymatic detection, flexible biosensors, organic electrochemical transistors, uric acid, wound care, Biosensors, Organic acids, Bacterial infections, Enzymatic conversions, Healthcare resources, Limit of detection, Phosphate buffer salines, Real time monitoring, Regeneration process, Catalytic oxidation
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-49483DOI: 10.1002/admi.202001218Scopus ID: 2-s2.0-85092180476OAI: oai:DiVA.org:ri-49483DiVA, id: diva2:1477144
Note

Funding details: Stiftelsen för Strategisk Forskning, SSF, RIT15‐0119; Funding details: Knut och Alice Wallenbergs Stiftelse; Funding text 1: V.B. would like to acknowledge the Swedish Foundation for Strategic Research (BioCom Lab, grant RIT15‐0119) for financial support. C.D., M.B., and D.T.S. acknowledge the support provided by the Swedish Foundation for Strategic Research and the Knut and Alice Wallenberg Foundation for this research. This work was conducted within the framework of the BioCom Lab projects. 

Available from: 2020-10-16 Created: 2020-10-16 Last updated: 2023-06-08Bibliographically approved

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Beni, Valerio

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