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DendroPrime as an adhesion barrier on fracture fixation plates: an experimental study in rabbits
Karolinska Institutet, Sweden.
Karolinska Institutet, Sweden.
KTH Royal Institute of Technology, Sweden; Biomedical Bonding AB, Sweden.
KTH Royal Institute of Technology, Sweden.
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2020 (English)In: Journal of Hand Surgery, European Volume, ISSN 1753-1934, E-ISSN 2043-6289, Vol. 45, no 7, p. 742-747Article in journal (Refereed) Published
Abstract [en]

We tested the anti-adhesional effect of a new thiol-ene-based coating in a rabbit model. In 12 New Zealand white rabbits, the periosteum and cortex of the proximal phalanx of the second toe of both hind paws was scratched. Stainless steel plates were fixated with screws. One plate was coated with DendroPrime and the other left bare. The non-operated second toes of both hind paws of an additional four rabbits served as controls. Seven weeks after surgery, the soft tissue adhesion to the plates was evaluated macroscopically, and joint mobility was measured biomechanically. Toe joint mobility was about 20% greater and statistically significant in specimens with coated plates compared with the bare plates. Soft tissue overgrowth and, in some cases, synovitis or adhesions between the plate and the tendon were observed on all bare plates but not on any of the coated plates. We conclude that the thiol-ene-based coating can improve joint mobility by about 20%. This material has a potential to reduce adhesion around plates in fracture surgery. © The Author(s) 2020.

Place, publisher, year, edition, pages
SAGE Publications Ltd , 2020. Vol. 45, no 7, p. 742-747
Keywords [en]
adhesion barrier, flexor tendon, Fracture, plate fixation, rabbit
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-45161DOI: 10.1177/1753193420932477Scopus ID: 2-s2.0-85086649097OAI: oai:DiVA.org:ri-45161DiVA, id: diva2:1452885
Available from: 2020-07-08 Created: 2020-07-08 Last updated: 2023-06-02Bibliographically approved

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