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Human Dermal Fibroblast Viability and Adhesion on Cellulose Nanomaterial Coatings: Influence of Surface Characteristics.
Åbo Akademi University, Finland.
Åbo Akademi University, Finland.
South China University of Technology, China.
Åbo Akademi University, Finland.
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2020 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602Article in journal (Refereed) Epub ahead of print
Abstract [en]

Biodegradable and renewable materials, such as cellulose nanomaterials, have been studied as a replacement material for traditional plastics in the biomedical field. Furthermore, in chronic wound care, modern wound dressings, hydrogels, and active synthetic extracellular matrices promoting tissue regeneration are developed to guide cell growth and differentiation. Cells are guided not only by chemical cues but also through their interaction with the surrounding substrate and its physicochemical properties. Hence, the current work investigated plant-based cellulose nanomaterials and their surface characteristic effects on human dermal fibroblast (HDF) behavior. Four thin cellulose nanomaterial-based coatings produced from microfibrillar cellulose (MFC), cellulose nanocrystals (CNC), and two TEMPO-oxidized cellulose nanofibers (CNF) with different total surface charge were characterized, and HDF viability and adhesion were evaluated. The highest viability and most stable adhesion were on the anionic CNF coating with a surface charge of 1.14 mmol/g. On MFC and CNC coated surfaces, HDFs sedimented but were unable to anchor to the substrate, leading to low viability.

Place, publisher, year, edition, pages
2020.
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Natural Sciences
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URN: urn:nbn:se:ri:diva-44563DOI: 10.1021/acs.biomac.0c00107PubMedID: 32150393OAI: oai:DiVA.org:ri-44563DiVA, id: diva2:1416608
Available from: 2020-03-24 Created: 2020-03-24 Last updated: 2020-03-24Bibliographically approved

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