Microspheres are hollow bubbles with a wide range of shell materials available on the market. Gases may enter microspheres via diffusion provided that the temperature is raised. In this paper we used polymeric microspheres to incorporate and control the level of Ar in reference material made by PM HIP, and glass (SiO2) microspheres to incorporate H2 for oxide reduction of PM HIP material. For the incorporation of Ar via polymeric microspheres, we failed to control all factors in the tests with Ar. In spite of that, we can utilize this method to create a homogenous reference material. For the incorporation of H2 via glass (SiO2) microspheres, higher filling pressure is permitted owing to the higher strength of this material. Up to 700 bar filling pressure has been achieved in work aiming for automotive applications. Once the microsphere, after filling, regain room temperature the H2 is locked inside and may be handled safely. We have used this idea to reduce internal and surface oxides on metal powders in the canisters before Hot Isostatic Pressing (HIP), with good results.