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Biocompatibility of glycerol monooleate nanoparticles as tested on inner ear cells
University of Padua, Italy.
Ear Science Institute Australia, Australia; University of Western Australia, Australia.
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation.ORCID iD: 0000-0003-4742-1702
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation.ORCID iD: 0000-0001-8971-3397
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2019 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 572, article id 118788Article in journal (Refereed) Epub ahead of print
Abstract [en]

Sensorineural hearing loss due to aging, noise exposure, trauma or drug ototoxicity is irreversible because cochlear hair cells and neurons cannot regenerate. Recently, therapeutic strategies involving nanoparticles have been developed as innovative drug delivery systems. Thermodynamically stable liquid crystalline nanoparticles based on the polar lipid glycerol monooleate (GMO NP, cubosomes), nontoxic and able to encapsulate both hydrophilic and hydrophobic compounds, were produced and tested for biocompatibility in an immortalized Organ of Corti derived cell line (OC-k3), through cell viability and cytomorphological assays, and Western blot expression profiles of apoptotic markers. Overall, the GMO NP were biocompatible in OC-k3 at the doses and time tested, supporting previous data obtained in a neuronal cell line (PC12). The results encourage further tests on GMO NP-mediated drug release with improved target specificity and could be useful to develop innovative therapies against sensorineural hearing loss.

Place, publisher, year, edition, pages
Elsevier B.V. , 2019. Vol. 572, article id 118788
Keywords [en]
Apoptosis, Cell cycle, Cubosome, OC-k3 cells, Toxicity
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-40932DOI: 10.1016/j.ijpharm.2019.118788Scopus ID: 2-s2.0-85075399346OAI: oai:DiVA.org:ri-40932DiVA, id: diva2:1376728
Note

Funding details: Prat-CPDA110048; Funding details: Ministero dell’Istruzione, dell’Università e della Ricerca, MIUR, PRIN-2010S58B38_004; Funding text 1: This work was supported by the Italian Ministry of Education, University and Research (MIUR) , Italy [grant n. PRIN-2010S58B38_004 ] and the University of Padua (grant n. Prat-CPDA110048 ).

Available from: 2019-12-10 Created: 2019-12-10 Last updated: 2020-01-17Bibliographically approved

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Boge, LukasEriksson, Mimmi

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