Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Ultrapure Wood Nanocellulose - Assessments of Coagulation and Initial Inflammation Potential
NTNU Norwegian University of Science and Technology, Norway.
NTNU Norwegian University of Science and Technology, Norway; Trondheim University Hospital, Norway.
RISE - Research Institutes of Sweden, Bioeconomy, PFI.ORCID iD: 0000-0002-6183-2017
NTNU Norwegian University of Science and Technology, Norway; dCentre of Molecular Inflammation Research, Norway; St. Olavs University Hospital, Norway.
2019 (English)In: ACS Applied Bio Materials, ISSN 2576-6422, Vol. 2, no 3, p. 1107-1118Article in journal (Refereed) Published
Abstract [en]

Using a lepirudin-based human whole blood model, we evaluated the initial inflammatory and coagulation responses of dense and porous ultrapure (<50 endotoxin units/grams) cellulose nanofibrils (CNF), of carboxylated grade. The CNF was compared to the wound dressing AquaCel because it is a potential wound-healing material. The porous CNF aerogels induced the strongest coagulation potential measured as prothrombin factor 1.2 (PTF1.2). AquaCel induced the strongest complement response by terminal complement complex (TCC) and surface C3c. All materials activated leukocytes CD11b, while the levels of only 3 of 27 cytokines were significantly changed, limited to (i) an elevation of the monocyte chemoattractant protein-1 (MCP-1/CCL) by the CNF aerogel, (ii) a reduction of eosinophil chemotactic proteins (eotaxin/CCL11) by the CNF aerogel, and (iii) a reduction of platelet-derived growth factor BB (PDGF-BB) by all CNF materials. In conclusion, the CNF materials and AquaCel differently activate coagulation, complement, and cytokines, improving the selection possibilities in various treatment situations of wound healing.

Place, publisher, year, edition, pages
American Chemical Society , 2019. Vol. 2, no 3, p. 1107-1118
Keywords [en]
coagulation, complement, cytokines, human whole blood model, ultrapure cellulose nanofibrils, wound dressings, Aerogels, Blood, Cellulose, Image storage tubes, Nanocellulose, Nanofibers, Proteins, Cellulose nanofibrils, Whole blood, Surgical Dressings
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-40843DOI: 10.1021/acsabm.8b00711Scopus ID: 2-s2.0-85070532867OAI: oai:DiVA.org:ri-40843DiVA, id: diva2:1372644
Note

Funding details: 283895, 219733; Funding details: Institute of Infection and Immunity, III; Funding details: European Commission, EC; Funding text 1: The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. This work was funded by the Research Council of Norway through the NANO2021 Program, Grant no. 219733, “NanoHeal: BioCompatible Cellulose Nanostructures for Advanced Wound Healing Applications” and Grant no. 283895, “MedIn: New functionalized medical devices for surgical interventions in the pelvic cavity”. The authors acknowledge the European Commission for funding through the MANUNET III program, MedIn project no. MNET17/NMCS-1204. The authors thank the Norwegian Micro- and Nano-Fabrication Facility for the AFM and STEM analyses (Grant no. 197411/V30). The authors declare no competing financial interest.

Available from: 2019-11-25 Created: 2019-11-25 Last updated: 2019-11-25Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records BETA

Chinga-Carrasco, Gary

Search in DiVA

By author/editor
Chinga-Carrasco, Gary
By organisation
PFI
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 5 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
v. 2.35.9