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Influence of high hydrostatic pressure on solid supported DPPC bilayers with hyaluronan in the presence of Ca2+ ions
Institute of Materials Research, Germany.
Institute of Materials Research, Germany.
KTH Royal Institute of Technology, Sweden.
Fakultät Physik/DELTA, Germany.
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2019 (English)In: Soft Matter, ISSN 1744-683X, E-ISSN 1744-6848, Vol. 15, no 36, p. 7295-7304Article in journal (Refereed) Published
Abstract [en]

The molecular mechanisms responsible for outstanding lubrication of natural systems, like articular joints, have been the focus of scientific research for several decades. One essential aspect is the lubrication under pressure, where it is important to understand how the lubricating entities adapt under dynamic working conditions in order to fulfill their function. We made a structural investigation of a model system consisting of two of the molecules present at the cartilage interface, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and hyaluronan, at high hydrostatic pressure. Phospholipid layers are found at the cartilage surfaces and are able to considerably reduce friction. Their behavior under load and varied solution conditions is important as pressures of 180 bar are encountered during daily life activities. We focus on how divalent ions, like Ca2+, affect the interaction between DPPC and hyaluronan, as other investigations have indicated that calcium ions influence their interaction. It could be shown that already low amounts of Ca2+ strongly influence the interaction of hyaluronan with DPPC. Our results suggest that the calcium ions increase the amount of adsorbed hyaluronan indicating an increased electrostatic interaction. Most importantly, we observe a modification of the DPPC phase diagram as hyaluronan absorbs to the bilayer which results in an Lα-like structure at low temperatures and a decoupling of the leaflets forming an asymmetric bilayer structure.

Place, publisher, year, edition, pages
Royal Society of Chemistry , 2019. Vol. 15, no 36, p. 7295-7304
Keywords [en]
Calcium, Cartilage, Hyaluronic acid, Hydraulics, Hydrostatic pressure, Lubrication, Phospholipids, 1, 2-Dipalmitoyl-Sn-glycero-3-phosphocholine, Asymmetric bilayers, Daily life activities, High hydrostatic pressure, Molecular mechanism, Scientific researches, Solution conditions, Structural investigation, Ions
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-39982DOI: 10.1039/c9sm01066aOAI: oai:DiVA.org:ri-39982DiVA, id: diva2:1359570
Note

 Funding details: 05K2012; Funding text 1: We acknowledge the BMBF Röntgen Angström Cluster JOINT (05K2012) for financial support. Further we thank Veijo Honkimaki, ESRF, Grenoble, for support during the beam time.

Available from: 2019-10-09 Created: 2019-10-09 Last updated: 2019-10-09Bibliographically approved

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