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Comprehensive characterization of silica-modified silicon rubbers
ICECHIM, Romania.
ICECHIM, Romania.
ICECHIM, Romania.
ICECHIM, Romania.
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2020 (English)In: Journal of The Mechanical Behavior of Biomedical Materials, ISSN 1751-6161, E-ISSN 1878-0180, Vol. 101, article id 103427Article in journal (Refereed) Published
Abstract [en]

In this study a commercially liquid silicone rubber was filled with fumed silica particles in different concentrations and evaluated for medical applications. The thermal, morphological and mechanical properties of silicone/silica composite samples were studied before and after aging, flexural tests and immersion in saline environment. Understanding the effect of silica content, aging conditions and thickness (from 0.6 to 2 mm) of the samples on the behavior of these materials in different environments is crucial for applications as implantable devices. Before inducing any mechanical stress, tensile strength was found to increase for samples containing 3 or 5 wt% of fumed silica, depending on the thickness. A similar trend was observed after 106 flexes for tensile strength, storage modulus and hardness at room temperature, which increased with the concentration of fumed silica. Moreover, tensile strength decreased with increasing the thickness of the samples from 0.6 to 2 mm. The thermal degradation was found to start at higher temperature in the case of the composites as compared with neat silicone, however, the glass transition and melting temperatures were only slightly modified by the presence of the silica particles, regardless the mechanical aging. The MTT assay using L929 fibroblasts mouse cells showed a good short-time cytocompatibility for both silicone elastomer and the composite with 3 wt% fumed silica. Similarly, the measurement of the cytokine secretion revealed no inflammatory response.

Place, publisher, year, edition, pages
Elsevier Ltd , 2020. Vol. 101, article id 103427
Keywords [en]
Cell culture, Glass transition, Implants (surgical), Medical applications, Rubber, Rubber applications, Silica, Silicon, Silicon rubber, Silicone rubber, Cytokine secretions, Fumed silica particles, Implantable devices, Inflammatory response, Liquid silicone rubbers, Mechanical stress, Saline environment, Silicone elastomers, Tensile strength
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Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-39984DOI: 10.1016/j.jmbbm.2019.103427OAI: oai:DiVA.org:ri-39984DiVA, id: diva2:1359538
Note

Funding details: 283895, MNET17/NMCS-1204; Funding details: 33/2018, COFUND-MANUNET III-MedIn-1; Funding text 1: This work was supported by a grant of the Romanian National Authority for Scientific Research and Innovation , CCCDI – UEFISCDI, project number COFUND-MANUNET III-MedIn-1, within PNCDI III, contract no. 33/2018 , and by the Research Council of Norway , Grant: 283895 , through the MedIn project, MNET17/NMCS-1204 – “New functionalized medical devices for surgical interventions in the pelvic cavity”. Appendix A

Available from: 2019-10-09 Created: 2019-10-09 Last updated: 2019-10-09Bibliographically approved

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Chinga-Carrasco, Gary

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