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Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall
Wihuri Research Institute, Finland.
Wihuri Research Institute, Finland.
RISE - Research Institutes of Sweden, Bioscience and Materials, Chemistry and Materials.ORCID iD: 0000-0002-2696-7215
Wihuri Research Institute, Finland.
2019 (English)In: Current Medicinal Chemistry, ISSN 0929-8673, E-ISSN 1875-533X, Vol. 26, no 9, p. 1701-1710Article in journal (Refereed) Published
Abstract [en]

Apolipoprotein B -containing lipoproteins include triglyceride-rich lipoproteins (chylomicrons and their remnants, and very low-density lipoproteins and their remnants) and cholesterol-rich low-density lipoprotein particles. Of these, lipoproteins having sizes below 70-80 nm may enter the arterial wall, where they accumulate and induce the formation of atherosclerotic lesions. The processes that lead to accumulation of lipoprotein-derived lipids in the arterial wall have been largely studied with a focus on the low-density lipoprotein particles. However, recent observational and genetic studies have discovered that the triglyceriderich lipoproteins and their remnants are linked with cardiovascular disease risk. In this review, we describe the potential mechanisms by which the triglyceride-rich remnant lipoproteins can contribute to the development of atherosclerotic lesions, and highlight the differences in the atherogenicity between low-density lipoproteins and the remnant lipoproteins.[on SciFinder (R)]

Place, publisher, year, edition, pages
2019. Vol. 26, no 9, p. 1701-1710
Keywords [en]
chylomicron, vldl, atherosclerosis, cholesterol, inflammation, remnant, triglyceride.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-39208DOI: 10.2174/0929867325666180530094819PubMedID: 29848270OAI: oai:DiVA.org:ri-39208DiVA, id: diva2:1327970
Available from: 2019-06-20 Created: 2019-06-20 Last updated: 2019-06-20Bibliographically approved

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Sjövall, Peter

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