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A Device that Models Human Swallowing
RISE - Research Institutes of Sweden, Bioscience and Materials, Agrifood and Bioscience. Chalmers University of Technology, Sweden.ORCID iD: 0000-0003-0310-4465
RISE - Research Institutes of Sweden, Bioscience and Materials, Agrifood and Bioscience. Chalmers University of Technology, Sweden.
Animato Konstruktions AB, Sweden.
RISE - Research Institutes of Sweden, Bioscience and Materials, Agrifood and Bioscience.ORCID iD: 0000-0002-7856-2324
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2019 (English)In: Dysphagia (New York. Print), ISSN 0179-051X, E-ISSN 1432-0460Article in journal (Refereed) Epub ahead of print
Abstract [en]

The pharynx is critical for correct swallowing, facilitating the transport of both air and food transport in a highly coordinated manner, and aberrant co-ordination causes swallowing disorders (dysphagia). In this work, an in vitro model of swallowing was designed to investigate the role of rheology in swallowing and for use as a pre-clinical tool for simulation of different routes to dysphagia. The model is based on the geometry of the human pharynx. Manometry is used for pressure measurements and ultrasonic analysis is performed to analyze the flow profiles and determine shear rate in the bolus, the latter being vital information largely missing in literature. In the fully automated model, bolus injection, epiglottis/nasopharynx movement, and ultrasound transducer positioning can be controlled. Simulation of closing of the airways and nasal cavity is modulated by the software, as is a clamping valve that simulates the upper esophageal sphincter. The actions can be timed and valves opened to different degrees, resembling pathologic swallowing conditions. To validate measurements of the velocity profile and manometry, continuous and bolus flow was performed. The respective velocity profiles demonstrated the accuracy and validity of the flow characterization necessary for determining bolus flow. A maximum bolus shear rate of 80 s−1 was noted for syrup-consistency fluids. Similarly, the manometry data acquired compared very well with clinical studies. © 2019, The Author(s).

Place, publisher, year, edition, pages
2019.
Keywords [en]
Deglutition, Deglutition disorders, In vitro, Manometry, Pharynx, Rheology, Shear rate
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-37754DOI: 10.1007/s00455-018-09969-2Scopus ID: 2-s2.0-85060660119OAI: oai:DiVA.org:ri-37754DiVA, id: diva2:1287476
Available from: 2019-02-11 Created: 2019-02-11 Last updated: 2019-02-11Bibliographically approved

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Stading, MatsWiklund, Johan

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