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Development of a sensitive induction-based magnetic nanoparticle biodetection method
RISE - Research Institutes of Sweden (2017-2019), ICT, Acreo.ORCID iD: 0000-0002-6148-3574
RISE - Research Institutes of Sweden (2017-2019), ICT, Acreo.ORCID iD: 0000-0001-9597-0429
RISE - Research Institutes of Sweden (2017-2019), ICT, Acreo.ORCID iD: 0000-0002-3618-9496
RISE - Research Institutes of Sweden (2017-2019), ICT, Acreo.ORCID iD: 0000-0003-0792-7039
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2018 (English)In: Nanomaterials, E-ISSN 2079-4991, Vol. 8, no 11, article id 887Article in journal (Refereed) Published
Abstract [en]

We developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz–10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10−5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM.

Place, publisher, year, edition, pages
2018. Vol. 8, no 11, article id 887
Keywords [en]
AC susceptibility, Brownian relaxation, Magnetic biosensing, Magnetic nanoparticles, Multi-core particles
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-36359DOI: 10.3390/nano8110887Scopus ID: 2-s2.0-85056217345OAI: oai:DiVA.org:ri-36359DiVA, id: diva2:1266272
Available from: 2018-11-27 Created: 2018-11-27 Last updated: 2023-06-08Bibliographically approved

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Blomgren, JakobAhrentorp, FredrikIlver, DagJonasson, ChristianSepehri, SobhanJohansson, Christer

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